Secondary hypothyroidism: specific features of diagnosis and treatment

Nagayeva, Ye. V.; Безлепкина, О. Б.; Goncharov, N. P.; Kolesnikova, G S; Петеркова, В. А.

doi:10.14341/probl11714

Cited by 2 publications

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“…Исследования Е.В. Нагаевой включали изучение композиционного состава тела, подбор оптимальной дозы препарата рГР у взрослых пациентов, особенности течения гипопитуитаризма [ 39 ][ 40 ].…”

Section: стг-дефицит у взрослыхunclassified

Growth hormone — 30 years of clinical practice: past, present, future

Dedov,

Bezlepkina,

Pankratova

et al. 2024

Probl Endokrinol (Mosk)

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The recombinant technologies era, which began in the second half of the XX century, made it possible to produce recombinant growth hormone (rGH) necessary for the treatment of stunting of various genesis. The time of practically unlimited possibilities of rGH production has come, which served as a stimulus for studying the efficacy and safety of rGH application, searching for optimal ways of its use and dosing regimes. Many years of experience in the use of somatropin in clinical practice allowed us to obtain data on its effectiveness primarily in somatotropic insufficiency in children, to study its effect on the functional state of various organs and systems, and to expand the indications for the use of RGR.

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Section: стг-дефицит у взрослыхunclassified

Growth hormone — 30 years of clinical practice: past, present, future

Dedov,

Bezlepkina,

Pankratova

et al. 2024

Probl Endokrinol (Mosk)

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Hormonal status of patients with external genital endometriosis combined with hypothyroidism

Lysenko¹,

Хабрат²,

Lytvak³

et al. 2019

Clin. and prev. med.

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Objective – to determine the hormonal status of patients with genital endometriosis combined with hypothyroidism. Material and methods. The present prospective studydemonstrated the results of the preoperative examinationof patients with genital endometriosis combined with hypothyroidism. The study groups was formed: 1 group (n=50): 10 women – infertility and with the pelvic peritoneum endometriosis, 40 – dysmenorrhea, dyspareunia and endometrial ovarian cysts. Group 2 included 60 women with hypothyroidism and external genital endometriosis. The age of women in group 1 amounted to 31.7±1.7 year, in group 2 – 35.4±1.3 year. Results. TTH hyperproduction in patients with genital endometriosis and hypothyroidism produces a the level of estrogen (25.9%) decrease and the level of follicle-stimulating hormone (20.8%) and increasing production of prolactin (28.6%); inverse correlation between tireotropin hormone and facultatem (r=-0,51; t=4,12); negative correlation between tireotropin hormone and estradol (r=-0,62; t=5,48); direct correlation between the secretion of tireotropic hormone and the amount of prolactin (r=0,63; t=5,61). The frequency of extragenital pathology in women with genital endometriosis is 30.6%, its structure is dominated by pathology of the thyroid gland (56,2%); gastrointestinal tract (21.1 per cent) and cardiovascular diseases (12.5 percent). Among all women with thyroid pathology at 94.9% is hypothyroidism. In the structure of various degrees endometrioma lesions in women with hypothyroidism was: I degree – 27,0% – adenomyosis; II degree – 23.0% – endometrial ovarian cysts and endometriosis of the peritoneum; III degree – 38,0% – endometrial ovarian cysts and adenomyosis; IV degree – 12.0% – adenomyosis and endometriosis of retrocervical region. Conclusions. Women with different forms ofendometriosis need a examination of the thyroid gland functional state before surgery. The women with genital endometriosis combined with hypothyroidism should also be considered together with the endocrinologist in the development of preoperative preparation. Implementation of the results will increase the effectiveness of treatment of women with genital endometriosis combined with hypothyroidism of reproductive age.

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Secondary hypothyroidism: specific features of diagnosis and treatment

Abstract: The article is devoted to the secondary hypothyroidism: specific features of diagnosis and treatment

Cited by 2 publications

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Growth hormone — 30 years of clinical practice: past, present, future

Growth hormone — 30 years of clinical practice: past, present, future

Hormonal status of patients with external genital endometriosis combined with hypothyroidism

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