Secondary ion mass spectrometry of organic materials with the use of a glycerol matrix

Melnikov, V. N.; Litvinov, V. A.; Koppe, V. T.; Bobkov, V. V.

doi:10.1134/s0036024409060193

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…In recent years, this technique has been widely used for solving problems in organic chemistry, biology and medicine (Henry and Bertrand, ; Zheng et al ., ; Nygren and Malmberg, ). There is a variant of secondary ion mass spectrometry in which the substance investigated is placed in liquid (also called a liquid matrix) bombarded with accelerated ions or atoms (Cozzolino et al ., ; Melnikov et al ., ; Kosevich et al ., ). The main advantage of this technique is that it allows the study of reactions in bio‐organic systems at various intermediate stages rather than just at the very final stage (Melnikov et al ., ).…”

Section: Introductionmentioning

confidence: 98%

Finite Mixture Modelling in Mass Spectrometry Analysis

Melnykov

2013

Journal of the Royal Statistical Society Series C: Applied Statistics

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Secondary ion mass spectrometry is a popular physical technique that allows learning elemental and chemical compositions of various substances. In some cases, the mass spectrum of the sample studied is not observable without that of the liquid solution in which the investigated substance must be placed. To separate the informative part of the observed mixed spectrum from the irrelevant liquid solution part, we develop an approach that is based on finite mixtures. Finite mixture modelling is a statistical technique that is capable of accounting for various shapes and patterns in data. We discuss a mixture model constructed with bell-shaped discrete component distributions that can be employed in the mass spectrometry framework for extracting the informative part of the mixed spectrum of organic objects. The results for assessing variability in the mass spectrum extracted are derived. The procedure is thoroughly illustrated on simulated data sets and applied to several real life problems that are concerned with complex organic dyes placed in a glycerol liquid matrix. The results obtained have clear chemical interpretation and suggest that the approach proposed is very promising.

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Section: Introductionmentioning

confidence: 98%

Finite Mixture Modelling in Mass Spectrometry Analysis

Melnykov

2013

Journal of the Royal Statistical Society Series C: Applied Statistics

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Current literature in mass spectrometry

2009

J. Mass Spectrom.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of mass spectrometry. Each bibliography is divided into 11 sections: 1 Reviews; 2 Instrumental Techniques & Methods; 3 Gas Phase Ion Chemistry; 4 Biology/Biochemistry: Amino Acids, Peptides & Proteins; Carbohydrates; Lipids; Nucleic Acids; 5 Pharmacology/Toxicology; 6 Natural Products; 7 Analysis of Organic Compounds; 8 Analysis of Inorganics/Organometallics; 9 Surface Analysis; 10 Environmental Analysis; 11 Elemental Analysis. Within each section, articles are listed in alphabetical order with respect to author

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Secondary ion mass spectrometry of organic materials with the use of a glycerol matrix

Cited by 2 publications

References 13 publications

Finite Mixture Modelling in Mass Spectrometry Analysis

Finite Mixture Modelling in Mass Spectrometry Analysis

Current literature in mass spectrometry

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