Secondary Laryngeal Tumors: Report of Seven Cases With Review of the Literature

Abstract

\s=b\ Laryngeal metastases are uncommon, particularly if we consider only secondary involvement from the remote primary neoplasm, via lymphohematogenous dissemination. In the 21-year period from 1966 to 1986, only seven cases of secondary laryngeal cancers were observed at the Department of Otolaryngology of Padua (Italy) University. A review of the world literature resulted in the identification of 113 previously reported cases. Cutaneous melanoma is the neoplasm most frequently metastasizing to the larynx, but adenocarcinoma may also often occur, especially from renal origin. A correct differential diagnosis from primary laryngeal cancer is most important. Identification of tumor location beneath intact mucosa, use of particular biochemical and histochemical stains, and electron microscopy may assist in establishing the presence of a metastatic growth. The prognosis is almost generally unfavorable because laryngeal involvement often occurs with metastases to other organs.

Metastases to the Head and Neck: An Overview

“…The most frequently affected site is the supraglottis (35-40% of all cases) followed by the subglottis (10-20%) and glottis (5-10%). Synchronous involvement of multiple laryngeal sites, however, is common and observed in about 35% of all cases [30,33].…”

“…Laryngeal metastases increase with age (median 58 years, range 24-83 years) and are more common in males by a ratio of 2:1 [30,33].…”

Renal cell carcinoma metastasis to the vocal cord: A case report

“…Most studies described solitary metastasis to either the supraglottic, [9][10][11][12] or subglottic region, [13][14][15] two studies described involvement of both the supraglottic and glottic regions, [16,17] and one described metastases involving all three regions of the larynx. [3] [11] Supraglottic Dee et al 2000 [9] Supraglottic Mochimatsu et al 1993 [10] Supraglottic Miyamoto et al 1973 [12] Supraglottic Mehdi et al 2012 [16] Supraglottic and glottic Navarro et al 2000 [17] Supraglottic and glottic Maung et al 1987 [7] Glottic Allan Fields, J.…”

“…[3] [11] Supraglottic Dee et al 2000 [9] Supraglottic Mochimatsu et al 1993 [10] Supraglottic Miyamoto et al 1973 [12] Supraglottic Mehdi et al 2012 [16] Supraglottic and glottic Navarro et al 2000 [17] Supraglottic and glottic Maung et al 1987 [7] Glottic Allan Fields, J. 1966 [13] Subglottic Ferlito et al 1988 [15] Subglottic Greenberg et al 1992 [14] Subglottic Demir et al 2012 [3] Supraglottic, glottic and subglottic…”

Laryngeal metastasis as first presentation of hepatocellular carcinoma

“…The majority of laryngeal metastases correspond to malignant melanomas (39.1%) or carcinomas of distant origin such as the kidney (13.3%) (2,3). HCC only exceptionally metastasizes to the larynx.…”