Secondary malignant tumors of the thyroid gland

Jd, Mortensen; Woolner, Lewis B.; Bennett, Warren A.

doi:10.1002/1097-0142(195603/04)9:2<306::aid-cncr2820090217>3.0.co;2-i

Cited by 124 publications

(58 citation statements)

References 1 publication

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“…5,8) In numerous large cohort autopsy studies, the most common primary non-thyroidal origin of thyroid metastases was lung or breast. 1,[10][11][12] These thyroid metastases detected on autopsy tended to be clinically occult. Conversely, many clinical studies have showed that the most frequent primary non-thyroidal malignancy resulting in symptomatic or clinically evident thyroid metastases was RCC.…”

Section: Discussionmentioning

confidence: 96%

Ultrasonographic Classification of the Metastases to the Thyroid Gland

Lee

Shin

Han

et al. 2015

J Korean Thyroid Assoc

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Section: Discussionmentioning

confidence: 96%

Ultrasonographic Classification of the Metastases to the Thyroid Gland

Lee

Shin

Han

et al. 2015

J Korean Thyroid Assoc

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“…The incidence of thyroid metastasis in autopsy series has been found to vary from 0.5% to 10.1%, with the breast being the most common primary carcinoma site [1][2][3][4][5][6][7]. The incidence of thyroid metastases in clinical reports seems to have increased recently [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], with the most common primary carcinoma site being the kidney, followed by breast and lung [8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis

Sung

Lee

et al. 2011

Endocr J

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Metastasis to the thyroid gland is uncommon, with previous autopsy series showing incidence rates ranging from 0.5% to 10.1% [1][2][3][4][5][6][7]. Clinical reports have suggested, however, that the incidence of these metastases is increasing. The most common primary carcinoma sites in clinical reports are the kidneys, breasts, and lungs [8][9][10][11][12][13][14], although other primary carcinomas can also metastasize to the thyroid gland [15][16][17][18][19][20][21][22][23][24][25][26][27].Hepatocellular carcinoma (HCC) rarely metastasizes to the thyroid [6,23,[25][26][27]. Here, we describe a patient with an HCC metastasis to within a medullary thyroid carcinoma (MTC), that is, a tumor-in-tumor metastasis. To our knowledge, this is the first such clinically diagnosed case.Due to the relatively short survival times of patients with distant metastases, solitary thyroid tumors in patients with advanced carcinoma are not routinely evaluated. However, imaging modalities, including fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and ultrasonography (US) guided fine-needle aspiration biopsy (FNAB) of newly detected Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis abstract. Carcinoma metastasis to the thyroid is uncommon, but may be increasing. We describe here a patient with a metastasis of hepatocellular carcinoma (HCC) presenting within a medullary thyroid carcinoma (MTC). The thyroid tumor was detected synchronously with the hepatic lesion by FDG-PET imaging, and HCC metastasis within MTC was confirmed by histological analysis of the thyroid gland.

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“…The incidence of the metastasis rate of primary tumor to the thyroid gland in autopsy studies varies widely according to the investigator, from 1.25% to as high as 24.2% [2,15]. Breast and lung cancer are known to be the most frequent primary tumors metastasized to the thyroid in the autopsy data [2,3]. Clinically, renal cell carcinoma has been reported to be a frequent cause of metastasis in the thyroid [16].…”

Section: Discussionmentioning

confidence: 99%

“…When examining for the common physical characteristics of diffused goiter, it is difficult to diagnose metastasis to thyroid cancer from other malignancies unless the physician is familiar with the disease. Frequent primary lesions for metastatic thyroid cancer are kidney, lung, and breast [2,3]. Only 12 cases of metastasis from colon cancer to the thyroid have been reported since 1936 [4][5][6][7].…”

mentioning

confidence: 99%

Severe Hypothyroidism Induced by Thyroid Metastasis of Colon Adenocarcinoma: A Case Report and Review of the Literature

et al. 2006

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Abstract. An 85-year-old man who had undergone a right hemicolectomy for colon cancer presented with severe hypothyroidism and hoarseness 21 months after the operation. The serum thyrotropin (TSH) was markedly elevated to 118.14 µIU/mL and serum free thyroxine (fT4) level was markedly suppressed to 0.34 ng/dL. Symptoms of hoarseness and neck swelling were already evident 4 months prior at which time tests for normal thyroid function were performed. The patient was referred due to aggravated pain on his diffusely enlarged hard goiter. An enlarged thyroid with some calcification was noticed in the neck ultrasonography with multiple cervical lymphadenopathies. Core biopsy of the thyroid gland showed invasion of poorly differentiated adenocarcinoma cells. Immunohistochemical studies showed positive staining only for carcinoembryonic antigen (CEA). There were multiple lung parenchymal nodules and adrenal masses at the time of evaluation. The patient was started on palliative chemotherapy with thyroid hormone replacement and gradually became euthyroid. From these findings and the clinical observations, thyroid metastasis with hypothyroidism developing acutely from metastatic colon adenocarcinoma was diagnosed.

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Secondary malignant tumors of the thyroid gland

Cited by 124 publications

References 1 publication

Ultrasonographic Classification of the Metastases to the Thyroid Gland

Ultrasonographic Classification of the Metastases to the Thyroid Gland

Hepatocellular carcinoma eats medullary thyroid carcinoma, a case of tumor-in-tumor metastasis

Severe Hypothyroidism Induced by Thyroid Metastasis of Colon Adenocarcinoma: A Case Report and Review of the Literature

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