Secondary metabolite contents and safety assessment study of the aqueous extract from the Algerian Echium trygorrhizum Pomel roots

Nouri, Allaoua; Gasmi, Lakhdar; Safsaf, Amina; Harzallah, Daoud; Khennouf, Seddik; Dahamna, Saliha

doi:10.1016/j.jep.2022.115771

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…15 Although many of these plant species have been used traditionally to treat various diseases, most of them have not been studied scientifically. 16 This makes the use of medicinal plants for the pharmaceutical industry a virgin field in Algeria. 17 Among these aromatic plants, Chrysanthemum coronarium L. (CC) is an annual flowering plant belonging to the Asteraceae family widely distributed in the Mediterranean region.…”

Section: Introductionmentioning

confidence: 99%

Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats

Belmamoun,

Ammam,

Mhamdia

et al. 2023

Ind. J. Pharm. Edu. Res

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Background: Our study evaluated the effect of Chrysanthemum coronarium L. (CC) leaves on ethanol-induced acute gastric ulcers in Wistar rats. Materials and Methods: The organic extract of CC was obtained by Soxhlet extraction with methanol and then divided into two dose groups: 250 mg/kg and 500 mg/kg. Omeprazole was used as a positive control at 20 mg/ kg. Our extract was subjected to the separation of bioactive compounds by High-Performance Liquid Chromatography (HPLC). Lethality tests (LD 50 ) were carried out using standard procedures. Gastric protection was assessed by measuring gastric juice volume, total acidity, and free acidity. Gastric mucosal damage was assessed by histopathological examination. Results: Chromatographic analysis of the Methanolic Extract of Chrysanthemum coronarium L. (MECC) identified the presence of 19 phenolic compounds, representing 46.47% of the total sample. The dominant components were o-coumaric acid (9.55%), chlorogenic acid (6%), myricetin (4.19%), and benzoic acid (2.87%). Oral LD 50 value was more than 5000 mg/kg in rat. In the present study, the methanolic extract of CC decreased total and free gastric acidity (53.80±7.038 and 17.8±2.375 respectively) for the 500 mg/kg dose and (60.40±4.490 and 24.8±1.855 respectively) for the 250 mg/kg dose. Omeprazole also decreased free and total gastric acidity (54.40±3.092 and 20±2.449 respectively), compared with the ethanol groups (19.40±2.909 and 4.4±0.678 respectively). In the histological study, we found that the gastric mucosal barrier could be significantly strengthened when the rats were pretreated with 500 mg/kg of the MECC and showed almost normal histology compared with the ethanol-ulcerated groups. Conclusion: Based on the present results, we can conclude that CC leaves could be a promising food for the protection of the gastric mucosa against ethanol-induced lesions.

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Section: Introductionmentioning

confidence: 99%

Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats

Belmamoun,

Ammam,

Mhamdia

et al. 2023

Ind. J. Pharm. Edu. Res

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Toxicity monitoring signals analysis of selenite using microbial fuel cells

Lin

Liang

Yang

et al. 2023

Science of The Total Environment

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Biochemical properties and biological potential of Syzygium heyneanum with antiparkinson’s activity in paraquat induced rodent model

Saadullah,

Tariq,

Chauhdary

et al. 2024

PLoS ONE

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Syzygium heyneanum is a valuable source of flavonoids and phenols, known for their antioxidant and neuroprotective properties. This research aimed to explore the potential of Syzygium heyneanum ethanol extract (SHE) in countering Parkinson’s disease. The presence of phenols and flavonoids results in SHE displaying an IC50 value of 42.13 when assessed in the DPPH scavenging assay. Rats’ vital organs (lungs, heart, spleen, liver, and kidney) histopathology reveals little or almost no harmful effect. The study hypothesized that SHE possesses antioxidants that could mitigate Parkinson’s symptoms by influencing α-synuclein, acetylcholinesterase (AChE), TNF-α, and IL-1β. Both in silico and in vivo investigations were conducted. The Parkinson’s rat model was established using paraquat (1 mg/kg, i.p.), with rats divided into control, disease control, standard, and SHE-treated groups (150, 300, and 600 mg/kg) for 21 days. According to the ELISA statistics, the SHE treated group had lowers levels of IL-6 and TNF-α than the disease control group, which is a sign of neuroprotection. Behavioral and biochemical assessments were performed, alongside mRNA expression analyses using RT-PCR to assess SHE’s impact on α-synuclein, AChE, TNF-α, and interleukins in brain homogenates. Behavioral observations demonstrated dose-dependent improvements in rats treated with SHE (600 > 300 > 150 mg/kg). Antioxidant enzyme levels (catalase, superoxide dismutase, glutathione) were significantly restored, particularly at a high dose, with notable reduction in malondialdehyde. The high dose of SHE notably lowered acetylcholinesterase levels. qRT-PCR results indicated reduced mRNA expression of IL-1β, α-synuclein, TNF-α, and AChE in SHE-treated groups compared to disease controls, suggesting neuroprotection. In conclusion, this study highlights Syzygium heyneanum potential to alleviate Parkinson’s disease symptoms through its antioxidant and modulatory effects on relevant biomarkers.

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Secondary metabolite contents and safety assessment study of the aqueous extract from the Algerian Echium trygorrhizum Pomel roots

Cited by 3 publications

References 27 publications

Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats

Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats

Toxicity monitoring signals analysis of selenite using microbial fuel cells

Biochemical properties and biological potential of Syzygium heyneanum with antiparkinson’s activity in paraquat induced rodent model

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