Secondary metabolites as potential drug candidates against Zika virus, an emerging looming human threat: Current landscape, molecular mechanism and challenges ahead

Sadeer, Nabeelah Bibi; Kalamouni, Chaker El; Khalid, Asaad; Abdalla, Ashraf N.; Zengin, Gökhan; Van, Bao Le; Mahomoodally, Mohamad Fawzi

doi:10.1016/j.jiph.2023.03.008

Cited by 3 publications

(1 citation statement)

References 68 publications

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“…No specific treatment is currently available. However, natural products isolated from medicinal herbs have demonstrated inhibition of ZIKV in vitro [139]. Only one in vivo animal model is available, reporting the anti-ZIKV activity of emetine [140].…”

Section: Treatment and Prognosismentioning

confidence: 99%

Ocular Manifestations of Flavivirus Infections

Zina,

Hoarau,

Labetoulle

et al. 2023

Pathogens

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Flaviviruses are a group of positive-sense, single-stranded RNA viruses predominantly transmitted by arthropods (mainly mosquitoes) that cause severe endemic infections and epidemics on a global scale. They represent a major cause of systemic morbidity and death and are expanding worldwide. Among this group, dengue fever, the West Nile virus, yellow fever, Japanese Encephalitis, and, recently, the Zika virus have been linked to a spectrum of ocular manifestations. These manifestations encompass subconjunctival hemorrhages and conjunctivitis, anterior and posterior uveitis (inclusive of vitritis, chorioretinitis, and retinal vasculitis), maculopathy, retinal hemorrhages, and optic neuritis. Clinical diagnosis of these infectious diseases is primarily based on epidemiological data, history, systemic symptoms and signs, and the pattern of ocular involvement. Diagnosis confirmation relies on laboratory testing, including RT-PCR and serological testing. Ocular involvement typically follows a self-limited course but can result in irreversible visual impairment. Effective treatments of flavivirus infections are currently unavailable. Prevention remains the mainstay for arthropod vector and zoonotic disease control. Effective vaccines are available only for the yellow fever virus, dengue virus, and Japanese Encephalitis virus. This review comprehensively summarizes the current knowledge regarding the ophthalmic manifestations of the foremost flavivirus-associated human diseases.

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Section: Treatment and Prognosismentioning

confidence: 99%

Ocular Manifestations of Flavivirus Infections

Zina,

Hoarau,

Labetoulle

et al. 2023

Pathogens

View full text Add to dashboard Cite

show abstract

Nanoparticle electrochemical biosensors for virus detection

Baskar,

Madhivanan,

Atchudan

et al. 2025

Clinica Chimica Acta

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Ocular Manifestations of Flavivirus Infections

MEZIOU ZINA,

HOARAU,

LABETOULLE

et al. 2023

Preprint

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Flaviviruses are a group of positive sense single-stranded RNA viruses predominantly transmitted by arthropods (mainly mos-quitoes), that cause severe endemic infections and epidemics on a global scale. It represents a major cause of systemic morbidity and death that are expanding worldwide. Among this group, Dengue fever, West Nile virus, Yellow Fever, Japanese Encephalitis, and recently Zika virus have been linked to a spectrum of ocular manifestations. The latter encompass subconjunctival hemor-rhage and conjunctivitis, anterior and posterior uveitis (inclusive of vitritis, chorioretinitis, and retinal vasculitis), maculopathy, retinal hemorrhages, and optic neuritis. Clinical diagnosis of these infectious diseases is primarily based on epidemiological data, history, systemic symptoms and signs, and the pattern of ocular involvement. Diagnosis confirmation relies on laboratory testing, including RT-PCR and serological testing. Ocular involvement typically follows a self-limited course but can result in irreversible visual impairment. Effective treatment for flavivirus infections is currently unavailable. Prevention remains the mainstay for arthropod vector and zoonotic disease control. Effective vaccines are available only for Yellow Fever virus, Dengue virus and Japanese Encephalitis virus. This review comprehensively summarizes the current knowledge regarding the ophthalmic mani-festations of the foremost flavivirus-associated human diseases.

show abstract

Secondary metabolites as potential drug candidates against Zika virus, an emerging looming human threat: Current landscape, molecular mechanism and challenges ahead

Cited by 3 publications

References 68 publications

Ocular Manifestations of Flavivirus Infections

Ocular Manifestations of Flavivirus Infections

Nanoparticle electrochemical biosensors for virus detection

Ocular Manifestations of Flavivirus Infections

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