SECONDARY METABOLITES BY CHEMICAL SCREENING. 20. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium: III. Decarestrictines E to M.

Grabley, Susanne; Hammann, Peter; Hutter, K.‐J.; Kirsch, R.; Kluge, H.; Thiericke, Ralf; Mayer, M. S.; Zeeck, Axel

doi:10.7164/antibiotics.45.1176

Cited by 85 publications

(49 citation statements)

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“…1993 (3), which was described to be biologically inactive. In contrast, we observed a weak cytostatic effect of clonostachydiol (1) in proliferation assays (MTTreduction) with the cell lines L 1210, HT 29, and A 549 (IC5O=4.5, 4.2, and 5.7/ig/ml, respectively). Based on prior work on the macrodiolide elaiophylin1 2) the anthelmintic action of clonostachydiol was investigated in in vivo tests using lambs (30 to 40 kg body weight) artificially infected with infective stages of abomasumnematodes(Haemunchus cortortus).…”

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confidence: 42%

Secondary metabolites by chemical screening. 21. Clonostachydiol, a novel anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607).

et al. 1993

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Application of our chemical screening methodology2) to different new fungal isolates gave rise to the detection, isolation, structure elucidation, and widespread biological testing of a new fungal metabolite named clonostachydiol (1), which is related to the macrodiolides of the colletodiol family3 '4).The producing organism, strain FH-A 6607, was isolated from a soil sample collected near Rantepao, Sulawesi Island (Indonesia) and exhibited a characteristic brown to yellow colored mycelium. The typical conidiophores were found to be in close morphological analogy to gliocladium and are arranged in self-contained long rows (Fig.

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mentioning

confidence: 42%

Secondary metabolites by chemical screening. 21. Clonostachydiol, a novel anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607).

et al. 1993

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“…was comparable to that ofclofibrate at 100mg/kg. Besides the hypolipidemic action, decarestrictin D exhibits antiviral activity [95,96].…”

Section: Antibiotics Inhibiting the Late Stages Of Cholesterol Biosynmentioning

confidence: 99%

Antibiotics inhibiting the biosynthesis of cholesterol (a review)

Тренин

Катруха

1997

Pharm Chem J

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The several decades that have passed since the introduction of penicillin into medical practice is essentially the age of antibiotics. Their wide application was very fruitful and allowed the solution of a number of fundamental problems both in the field of infection pathology and in treating diseases of a non-infection nature [ 1,2]. As is well known, antibiotics are not only successfully used as antimicrobial preparations, but are also applied in oncology as antitumor drugs. Moreover, it was the discovery of microbial metabolites-immunomodulators and the creation of immunodepressants such as eyclosporin A and FK 506 that made possible surgical operations involving the transplantation of organs and tissues [3 -5].

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“…Outro exemplo importante de nonanolídeos é representado pela família das decarestrictinas 11 , que apresentaram significativo efeito inibitório na biossíntese do colesterol. Tais lactonas foram isoladas de extratos obtidos em processos de fermentação promovidos por espécies do gênero Penicillium.…”

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