Secondary Metabolites from Cinnamomum cebuense

Fierro, Ramon S. del; Maquilang, Queenie Marie A.; Sanjorjo, Ray Anthony S.; Tradio, Marcelino D.; Shen, Chien‐Chang; Ragasa, Consolacion Y.

doi:10.5897/jmpr11.1379

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Cinnamons are considered as multifaceted medicinal plants for their uses against a variety of ailments, including stomachache, headache, and toothache (Alimpoos et al 2018). Eugenol is one of the main phytochemical of Cinnamomum species including C. cebuense, possessing pharmacological properties (Del Fierro et al 2012). It was found to be cytotoxic against HL-60 leukemia cells (Hirata et al 2005), promyelocytic leukemia cells (Yoo et al 2005), U2OS human osteoblastic cells (Ho et al 2006), and colon cancer cells (Jaganathan et al 2011).…”

Section: Local Medicinal Usesmentioning

confidence: 99%

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Cinnamomum cebuense Kosterm Lauraceae

Dapar¹

2020

Ethnobotany of Mountain Regions

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Botany and Ecology Medium-sized tree, ca. 6-8 m. Bark, root, and crushed leaves aromatic with a characteristic smell of cloves (eugenol), sassafras (safrole), or a combination of these odors (Figs. 1 and 2). Twigs terete, ca. 1-5 mm diameter glabrous. Branchlets and bark smooth; terminal buds small, glabrous, not perulate. Leaves opposite, leathery, smooth, pale green, elliptic to ovate, ca. 16 cm long and 11 cm wide; base obtuse; apex acuminate; lateral veins ascend toward the leaf tip, intercostal veins scalariform; mature blades glabrous; margin entire. Inflorescences axillary (Fig. 3); panicles ca. 17 mm long, puberulous; paniculate cymose, branching, flowers of the ultimate branch arranged in cyme; rachis angular; bracts persistent. Flowers bisexual, trimerous, appressed hairy, receptacle tube shallow. Petals smooth and scarcely exerted. Fruit smooth, narrowly ellipsoid to obovoid ca. 2 cm long, ovoid to globose seated on cupule, drupaceous, epicarp waxy, glabrous, pericarp thin or thick, often fragrant. Seeds 1 per fruit, smooth, glabrous; endosperm absent; germination hypogeal (Fig. 4). Etymologically, this species was named for its type locality (Sitio Cantipla, Barangay Tabunan, Cebu City), where it was collected as described by Kostermans in 1986. Cinnamomum cebuense is one of 21 Cinnamomum species with complex

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Section: Local Medicinal Usesmentioning

confidence: 99%

“…(©L. M. Paguntalan)PhytochemistryDelFierro et al (2012) investigated the secondary metabolites present in Cinnamomum cebuense for the first time. Major constituents were identified and isolated from different parts of C. cebuense.…”

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confidence: 99%

Cinnamomum cebuense Kosterm Lauraceae

Dapar¹

2020

Ethnobotany of Mountain Regions

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“…Cinnamon, a highly prized spice plant, is among the herbal plants utilized by the locals in Cebu Island, Philippines. Aside from being a good source of essential oils and timber (Ravindran et al, 2004), it is also used as a remedy for gastric pains (Del Fierro et al, 2012), an antispasmodic (Jaafarpour et al, 2015), aromatic, astringent, antiseptic, germicidal, and a remedy for flatulence (Vijayan and Thampuran, 2004). There are 21 species of cinnamon that can be found in the Philippines, 16 of which are known to be endemic (Ragasa et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…C. cebuense Kosterm.is one of those endemic cinnamon trees that can only be found in Cebu Island, Philippines and it is commonly called as kaningag or kalingang. Its bark is popularly stripped for stomach ache, headache, and toothache remedies (del Fierro et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…C. cassia also exhibited antiangiogenesis in zebrafish bioassay and human umbilical vein endothelial cell (HUVEC) assay by inhibiting VEGFR1 and VEGFR2 (Bansode et al, 2012). Other studies reported that cinnamon extract can initiate apoptosis on active cancer cells (Kwon et al, 2010); and 2'-hydroxycinnamaldehyde from the bark of the cinnamon strongly inhibited the growth of gastric and colon cancer cell lines (Jin Won et al, 1994 Fierro, 2012;Ragasa et al, 2013;. β-amyrin and α-amyrin are pentacyclic triterpenes that exhibit anti-inflammatory effect (Basile et al, 1988) and reduce VEGF expression by immunohistochemistry (Bento et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Antiangiogenic and morphological effects of Cinnamomum cebuense Kosterm. leaf extracts on Anas platyrynchos L. embryonic development usingan in vivo chorioallantoic membrane (CAM) assay

2018

Int. J. Biosci.

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The theoretical efficacy of antiangiogenic treatment in tumor growth and other angiogenesis-dependent diseases offers a promising approach that leads to the robust search of angiogenesis inhibitors. Cinnamon species, widely used in food processing and other commercial industries, are among the medicinal plants currently being exploited by many cancer researches that involve inhibition of angiogenesis. The Cebu endemic Cinnamomum cebuense is popular for its bark as a remedy for stomachache, headache and toothaches. Phytochemicals found in many cinnamon species worldwide that were claimed to inhibit angiogenesis and tumor cell proliferation were also found in C. cebuense. However, there have been no reported studies that verified its antiangiogenic activity. In the present study, the C. cebuense' santiangiogenic property was investigated via CAM assay with five different treatments of C. cebuense's leaf aqueous extract (CCE) following a completely randomized design: 100% (T1), 50% (T2), 25% (T3), 12.5% (T4), and 6.25% (T5). Sixteen-day old duck eggs were harvested after 15 days incubation, embryos assessed morphologically, angiogenesis quantified by photo documentation of the CAMs, and fractal dimension index analyzed using Image J analysis software. Results revealed that crown to rump length (CRL), hindlimb, forelimb, and beak lengths for other treatments were not dose-dependent except for T1 (100%) where embryos were clearly stunted in all its morphological development. The lowest mean fractal index (MFI=0.3042) among the experimental groups was also evident in T1 (100%). The results show strong evidence that T1 (100%) is the most potent concentration for CCE that could inhibit angiogenesis, and thus possibly restrain proliferation and metastasis of cancer cells.

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Cinnamomum cebuense Kosterm Lauraceae

Dapar

2021

Ethnobotany of Mountain Regions

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Secondary Metabolites from Cinnamomum cebuense

Cited by 5 publications

References 23 publications

Cinnamomum cebuense Kosterm Lauraceae

Cinnamomum cebuense Kosterm Lauraceae

Antiangiogenic and morphological effects of Cinnamomum cebuense Kosterm. leaf extracts on Anas platyrynchos L. embryonic development usingan in vivo chorioallantoic membrane (CAM) assay

Cinnamomum cebuense Kosterm Lauraceae

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