Secondary metabolites from Lantana camara L. flowers extract exhibit in vivo anti-urolithiatic activity in adult Wistar albino rats

Abstract

The present study aims at evaluating the potential of the ethanol extracts of L. camara leaves (LE), flowers (FlE), and roots (RE) in the treatment of renal calculi and characterizing the secondary metabolites in the active extract. The results revealed that the FlE had significantly reduced the levels of kidney parameters (calcium, creatinine, urea, and uric acid) against ethylene glycol (EG) injures, and restored the activity of the natural antioxidants; glutathione peroxidase (GPx), superoxide dismutase (SOD) and lipid peroxide malondialdehyde (MDA) to the normal level. In addition, FlE significantly attenuated iNOS tissue expression caused by EG. The results obtained in this study suggest the potential value of the L. camara L. flowers as an antiurolithiatic agent.

Microwave and ultrasound extraction of antioxidant phenolic compounds from Lantana camara Linn. leaves: Optimization, comparative study, and FT‐Orbitrap MS analysis

“…These data corroborated the high antioxidant activity values presented by the L. camara extracts, since they were rich in phenolic compounds. Some of the compounds were identified previously in L. camara and/or other species of this genus 7,15,16,21,68–72 . The combination of FT‐Orbitrap MS information with that of several reports in the literature corroborated the proposed identification of iridoids, terpenoids, phenolic acids, phenylpropanoids, and flavonoids present in the extracts.…”

“…Some of the compounds were identified previously in L. camara and/or other species of this genus. 7,15,16,21,[68][69][70][71][72] The combination of FT-Orbitrap MS information with that of several reports in the literature corroborated the proposed identification of iridoids, terpenoids, phenolic acids, phenylpropanoids, and flavonoids present in the extracts. However, it is important to emphasize that FT-Orbitrap MS is a qualitative technique.…”

“…The exact masses of the ions produced in negative ionization mode [M − H] − could be converted to molecular formulas. The chemical structures were proposed based on data available in the literature for the identification of chemical compounds present in extracts from L. camara and/or different species of the genus Lantana , 7,15,16,21,68–72 as well databaseas in the PubChem 73…”

“…7,16 Strong correlation between TPC and/or TFC and antioxidant activities of plant extracts has been reported previously. 7,15,16,21,[68][69][70][71][72] as well databaseas in the PubChem. 73 Table 3 shows the theoretical masses of the ions in ascending S3 to S8).…”

Bioactivity of <i>Lantana camara</i> Flowers: Antilithiatic and Nephroprotective Implications in Male Wistar Rats

“…The methanolic extract of L. camara leaves has shown significant anti-ulcer and antioxidant activity in gastric and duodenal ulcer models 17 . Notably, the different parts of L. camara have also exhibited antilithiatic and nephroprotective activities against various diseaseinduced models [18][19][20][21][22][23] .…”