Secondary metabolites from lactic acid bacteria as a source of antifungal and antimycotoxigenic agents

Gacem, Mohamed Amine; Krantar, Kamel; Hadef, Sawsen; Boudjemaa, Badreddine

doi:10.1016/b978-0-323-95251-4.00003-x

Cited by 6 publications

(1 citation statement)

References 128 publications

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“…Many important properties of LP are related to its secreted exopolysaccharide (EPS), which has been extensively studied for its various probiotic effects 5 , anticancer properties 6 and natural ability to improve rheological and sensory properties of fermented foods 7 . In contrast to primary metabolites, the LP derived EPS is a typical secondary metabolite 8 , whose biosynthesis directly competes with growth coupled central carbon metabolism for the carbon source and energy. However, the mechanism behind the biosynthesis of EPS has not been well studied compared with its structural and functional properties, thus has long remained murky.…”

Section: Introductionmentioning

confidence: 99%

Proteome trade-off between primary and secondary metabolism shapes acid stress induced bacterial exopolysaccharide production

Qiu,

Yang,

Yang

et al. 2024

Preprint

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The exopolysaccharide (EPS) produced by Lactiplantibacillus plantarum is a high-value bioproduct in food and health industries, and its biosynthesis has been found as a secondary metabolic pathway to mediate acid stress. To quantitatively investigate acid stress response in L. plantarum and model EPS production, this study measured metabolomics, proteomics and growth data for L. plantarum HMX2 cultured at 4 different pH values. The growth and metabolomics data showed that under acid stress, the EPS production flux was evidently enhanced while the glycolysis and cellular growth were inhibited. The following proteomic analysis found that EPS biosynthetic proteins were significantly up-regulated under acid stress and pinpointed Fur as the most probable transcriptional factor controlling EPS biosynthesis in L. plantarum. Furthermore, we identified a proteome trade-off between primary metabolism and EPS biosynthesis, which were then mechanistically depicted by a regulatory proteome constrained flux balance analysis (RPCFBA) model. As the first metabolic model that can simulate secondary metabolism, the RPCFBA model demonstrated good accuracy in predicting growth rates and EPS production fluxes of L. plantarum HMX2, validated by experimental data. The in-silico perturbation on carbon sources further showed the potential of applying the presented modeling framework to the design and control of microbial secondary metabolism.

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Section: Introductionmentioning

confidence: 99%

Proteome trade-off between primary and secondary metabolism shapes acid stress induced bacterial exopolysaccharide production

Qiu,

Yang,

Yang

et al. 2024

Preprint

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Harnessing Trichoderma asperellum: Tri‐Trophic Interactions for Enhanced Black Gram Growth and Root Rot Resilience

Vijayakumar,

Appusami,

Anbazhagan

et al. 2024

Journal of Basic Microbiology

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Root rot caused by Macrophomina phaseolina, a common soil‐borne disease in black gram, is managed with chemical fungicides, leading to toxicity and degradation of beneficial soil microbes. Existing bioagents, like talc formulation, cause leaching, clogging, and reduced productivity. The development of liquid bio‐formulation via drip irrigation is crucial to mitigate biotic stress and maximize yield. This study aims to investigate the efficacy and survivability of liquid formulation of Trichoderma asperellum against root rot and its growth promotion. The results showed that Tv1 effectively inhibited M. phaseolina (66.67%), under in vitro condition. The vigor index of 4025.00 and the spore load of 1 × 108 cfu/mL were recorded from plant growth promotion and spermosphere study @ 5 mL/kg of seeds with formulation. The study found that combined application of seed treatment @ 5 mL/kg of seed and soil application @ 10 mL/L of water significantly reduced disease incidence (9.1%) against control (74.3%), with increased biomass index. There are 32 mVOCs profiled during the tritrophic interaction in roots of black gram and they were up or downregulated, viz., mollugin, pentadecanoic acid, cyclopropaneoctanoic acid, 2‐octyl‐, methyl ester, rhodopin, dodecanoic acid, 1,2,3‐propanetriyl ester by involved in defense mechanism and biosynthetic pathways like jasmonic acid, glyconeogenic and act as acyl‐CoA: acyltransferase 2 inhibitor. The results of this study confirmed that liquid formulation performs better in growth promotion, survivability on seed surface, and managing root rot of black gram compared talc‐based formulation.

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Mitigating aflatoxin contamination in food product using Limosilactobacillus fermentum LAB212

Mandal,

Barman,

Sen

et al. 2024

Food Bioscience

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Secondary metabolites from lactic acid bacteria as a source of antifungal and antimycotoxigenic agents

Cited by 6 publications

References 128 publications

Proteome trade-off between primary and secondary metabolism shapes acid stress induced bacterial exopolysaccharide production

Proteome trade-off between primary and secondary metabolism shapes acid stress induced bacterial exopolysaccharide production

Harnessing Trichoderma asperellum: Tri‐Trophic Interactions for Enhanced Black Gram Growth and Root Rot Resilience

Mitigating aflatoxin contamination in food product using Limosilactobacillus fermentum LAB212

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