Secondary metabolites from Scutellaria albida L. ssp. velenovskyi (Rech. f.) Greuter &amp; Burdet

Matsa, Marina; Bardakçı, Hilal; Gousiadou, Chrysoula; Kırmızıbekmez, Hasan; Skaltsa, Helen

doi:10.1016/j.bse.2019.01.006

Cited by 8 publications

(2 citation statements)

References 32 publications

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“…However, scutellarin is the one that is characteristic and present in all species studied by us, regardless of their habitat. In the plant material of S. albida from both regions, in addition to significant amounts of scutellarin, we also find the phenylethanoid glycoside-verbascoside, which was also identified by Matsa et al [ 27 ] as well as luteoline—determined by Bardakci et al [ 28 ] in S. albida subsp velenovskyi from the Karabük region of Turkey.…”

Section: Discussionsupporting

confidence: 82%

Metabolite Profile and Antioxidant Activity of Some Species of Genus Scutellaria Growing in Bulgaria

Georgieva

Stoyanov

et al. 2020

Plants

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Until now, the interest to plants from genus Scutellaria in Bulgaria has been focused mainly on the terpenes in them. The purpose of this study is to enrich the information on the composition of the Bulgarian Scutellaria species in terms of both polyphenolic content as well as primary metabolites such as mono-, oligosaccharides and organic acids. An aerial part of three Scutellaria species growing in four low mountain regions of Southern Bulgaria was used. The flavonoids scutellarin, baicalin, baicalein, wogonin, wogonoside, luteolin, chrysin and a caffeoyl phenylethanoid glycoside-verbascoside have been identified via HPLC in different extracts from Scutellaria altissima, Scutellaria albida and Scutellaria galericulata. The antioxidant activity of the extracts has been evaluated. The Scutellaria altissima from Mezek and Scutellaria galericulata from Parvenets we studied, which are the richest in flavonoids (represented mainly by baicalin, scutellarin and wogonoside), show the highest Oxygen Radical Absorption Capacity. Hydroxyl Radical Averting Capacity of Scutellaria albida from Mezek and Scutellaria altissima from Bachkovo is the most pronounced, probably due to the content of scutellarin and luteolin and chrysin, respectively. Antioxidant activity of aqueous, methanolic and 70% and 96% ethanol extracts were also determined by the electrochemical method.

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Section: Discussionsupporting

confidence: 82%

Metabolite Profile and Antioxidant Activity of Some Species of Genus Scutellaria Growing in Bulgaria

Georgieva

Stoyanov

et al. 2020

Plants

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“…It is revealed from S. altissima having high contents of phenols and flavonoids observed for S. edelbergii content [ 52 ]. Moreover, the bioactive compound scutellarin is present in the Scutellaria beside its habitats and environment, detected by Matsa et al [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

et al. 2021

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In the current study, in vitro antimicrobial and antioxidant activities and in vivo anti-inflammatory and analgesic activities of Scutellaria edelbergii Rech. f. (crude extract and subfractions, i.e., n-hexane, ethyl acetate (EtOAc), chloroform, n-butanol (n-BuOH) and aqueous) were explored. Initially, extraction and fractionation of the selected medicinal plant were carried out, followed by phytochemical qualitative tests, which were mostly positive for all the extracts. EtOAc fraction possessed a significant amount of phenolic (79.2 ± 0.30 mg GAE/g) and flavonoid (84.0 ± 0.39 mg QE/g) content. The EtOAc fraction of S. edelbergii exhibited appreciable antibacterial activity against Gram-negative (Escherichia coli and Klebsiella pneumoniae) strains and significant zones of inhibition were observed against Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus). However, it was found inactive against Candida Albicans and Fusarium oxysporum fungal strains. The chloroform fraction was the most effective with an IC50 value of 172 and 74 µg/mL against DPPH (1,1-Diphenyl-2-picryl-hydrazyl) and ABTS assays, in comparison with standard ascorbic acid 59 and 63 µg/mL, respectively. Moreover, the EtOAc fraction displayed significant in vivo anti-inflammatory activity (54%) using carrageenan-induced assay and significant (55%) in vivo analgesic activity using acetic acid-induced writing assay. In addition, nine known compounds, ursolic acid (UA), ovaul (OV), oleanolic acid (OA), β-sitosterol (BS), micromeric acid (MA), taraxasterol acetate (TA), 5,3′,4′-trihydroxy-7-methoxy flavone (FL-1), 5,7,4′-trihydroxy-6,3′-dimiethoxyflavone (FL-2) and 7-methoxy catechin (FL-3), were isolated from methanolic extract of S. edelbergii. These constituents have never been obtained from this source. The structures of all the isolated constituents were elucidated by spectroscopic means. In conclusion, the EtOAc fraction and all other fractions of S. edelbergii, in general, displayed a significant role as antibacterial, free radical scavenger, anti-inflammatory and analgesic agents which may be due to the presence of these constituents and other flavonoids.

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Phytochemical and chemotaxonomic study on Thymus quinquecostatus Cêlak

Jia,

Yang,

Wang

et al. 2024

Biochemical Systematics and Ecology

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Secondary metabolites from Scutellaria albida L. ssp. velenovskyi (Rech. f.) Greuter & Burdet

Cited by 8 publications

References 32 publications

Metabolite Profile and Antioxidant Activity of Some Species of Genus Scutellaria Growing in Bulgaria

Metabolite Profile and Antioxidant Activity of Some Species of Genus Scutellaria Growing in Bulgaria

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

Phytochemical and chemotaxonomic study on Thymus quinquecostatus Cêlak

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