Secondary metabolites from the endolichenic fungusOphiosphaerella korrae

Abstract

Six new metabolites were isolated from the endolichenic fungus Ophiosphaerella korrae. Ophiokorrin inhibited root elongation in the germination of Arabidopsis thaliana.

Endolichenic fungal diversity associated with some lichens of the Western Ghats

“…The majority of the studies on endolichenic fungi relate to their secondary metabolite spectrum because of the desirable properties exhibited by these metabolites [9,11,12]. Although similar to the endophytic fungi of higher plants, the function of endolichenic fungi in maintaining the complex lichen association is not known.…”

“…Very few lichens across the globe have been screened for their endophytic fungal assemblages, and all of them invariably harbour these fungi [8]. These endolichenic fungi appear to produce many novel metabolites with technologically exploitable bioactivities [9][10][11][12]. Although India supports 2511 species of lichens [13], very few species have been screened for their endolichenic fungal assemblage, and that too mostly from temperate regions of Central Himalaya (Uttarakhand) [14].…”

In pursuit of promising microbes for drug discovery: tapping endolichenic fungi (ELF) from lichens

“…Interestingly, in addition to the biopharmaceutical applications mentioned above, some of the ELF metabolites were also tested for their agricultural potential such as nematicidal [69], biocontrol [70], and phytotoxic activities [71,72]. In the Philippines, the first reports of ELF were that of Galinato et al [35], Santiago et al [36], and Tan et al [44].…”

Two New Neo-debromoaplysiatoxins—A Pair of Stereoisomers Exhibiting Potent Kv1.5 Ion Channel Inhibition Activities

“…Gauge-independent atomic orbital (GIAO) calculations of 1 H and 13 C NMR chemical shifts were accomplished by density functional theory (DFT) at the MPWLPW91-SCRF (methanol)/6-311+g (d, p) level with the polarizable continuum model (PCM) [29]. The experimental and calculated data were analyzed by the improved probability DP4+ [30][31][32], suggesting that the most probable structure for 1 was isomer 2 (4R, 9S, 10R, 11S, 12S) with a probability of 100% based on 1 H NMR, 100% based on 13 C NMR, and 100% when carbon and proton shifts were included. The most probable structure for 2 was isomer 2' (4S, 9R, 10S, 11R, 12R) with a probability of 99.98% based on 1 H NMR, 100% based on 13 C NMR, and 100% when carbon and proton shifts were included (Figure 7).…”

“…The 1 H and 13 C NMR chemical shifts for tetramethyl silane (TMS) were calculated by the same protocol and used as reference. The experimental and calculated data were analyzed by the improved probability DP4+ method for isomeric compounds [30][31][32]. A significantly higher DP4+ probability score of a compound suggested the correctness of its configuration.…”