Secondary metabolites from the fungus Porodaedalea pini

Yang, SS; Chan, HY; Hsieh, S. P. Y.; Yuan, Gwo‐Fang; Wong, S. C. Y.; Lin, CH; Cheng, MJ; Chen, IS; Chang, HS

doi:10.1055/s-0036-1596738

Cited by 3 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight benzenoids, namely 3 new piniphenols A−C and 5 previously known compounds: 4‐vinylphenol, 4‐hydroxybenzaldehyde, 2‐methoxy‐2‐(4′‐hydroxyphenyl)ethanol, 2,3‐dihydroxypropyl acetate, and phenol, were isolated from the extract ( Porodaedalea pini BCRC 35384) with the ethyl acetate layer of liquid fermentation [55] …”

Section: Phellinus Pinimentioning

confidence: 99%

Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications

Sułkowska-Ziaja

Balik

Muszyńska

2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

This study presents the current knowledge on chemical composition, biological activity, and possible medicinal applications of Phellinus igniarius, Phellinus pini, Phellinus pomaceus, and Phellinus robustus. These inedible arboreal species are phytopathogens that cause the enzymatic decomposition of wood. These species belong to the medicinal mushrooms and have been known for centuries in the traditional medicine of the Far East. They have been used as an effective remedy for stomach and intestinal ailments, diarrhea, and hemorrhages. Mycochemical studies have proved the presence of polysaccharides, phenolic compounds, and terpenoids. These compounds show biological activities such as anticancer, antioxidant, antiangiogenic, and antiviral. Research studies conducted using modern analytical methods have advanced the knowledge on the potential therapeutic use of compounds isolated not only from the fruiting bodies but also from biomass obtained with in vitro biotechnological methods.

show abstract

Section: Phellinus Pinimentioning

confidence: 99%

Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications

Sułkowska-Ziaja

Balik

Muszyńska

2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…(Root Tissues) [18] 17. 5α,8α-epidioxy-(22E,24 R)-23-methylergosta-6,22-dien-3β-ol (44) Gaeumannomyces sp. Phragmites communis [14] 18.…”

Section: -Methylcarbazole (2)mentioning

confidence: 99%

“…Ten compounds containing cyclopentanoperhydrophenanthrene as the basic nucleus (i.e., steroids [56]) had been reported from endophytic fungi, which belong to different genus. They were ergosterol-3-O-β-D-glucopyranoside (37), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (38), 3β,5α-dihydroxy-6β-methoxy ergosta-7,22diene (39), phomopsterone B (40), β-sitosterol (41), β-sitosterone (42), 5α,8α-epidioxyergosta-6,9(11),22-trien-3-ol (43), 5α,8αepidioxy-(22E,24 R)-23-methylergosta-6,22-dien-3β-ol (44), and fusaristerol A and B (45-46) (▶ Fig. 5).…”

Section: Ai Steroids and Related Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

2020

View full text Add to dashboard Cite

A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

show abstract

“…FIRDI 001, [5] Annulohypoxylon boveri var. microspora BCRC 34012, [6] Actinomadura miaoliensis BCRC 16873, [7] Acrocarpospora punica , [8] Porodaedalea pini (Hymenochaetaceae) BCRC 35384, [9] Monascus pilosus BCRC 38072 [10] and so on. Investigation of the bioactive metabolites of the active BuOH extract from the actinobacteria I. chiayiensis led to the isolation of one new isopterfuranone ( 1 ), one new sesquiterpenoid, isopterchiayione ( 2 ), one new benzenoid derivative, isopterinoid ( 3 ), five flavonoids, chiayiflavans A−E ( 4 – 8 ), and 4 metabolites isolated for the first time from nature sources, methyl 3‐(4‐methyl‐2,5‐dioxopyrrolidin‐3‐yl)propanoate ( 9 ), 3‐ethyl‐4‐methylpyrrolidine‐2,5‐dione ( 10 ), chiayiensol ( 11 ) and chiayiensic acid ( 12 ) ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from a Mangrove‐Derived Actinobacteria Isoptericola chiayiensis BCRC 16888 and Evaluation of Their Anti‐NO Activity

Cheng

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

Cultivation of the actinobacteria strain Isoptericola chiayiensis, a mangrove‐derived actinobacteria that was isolated from a mangrove soil collected in Chiayi County, resulted in the isolation of one new 2‐furanone derivative, isopterfuranone (1), one new sesquiterpenoid, isopterchiayione (2), one new benzenoid derivative, isopterinoid (3), five new flavonoids, chiayiflavans A−E (4–8), and 4 metabolites isolated for the first time from nature source, methyl 3‐(4‐methyl‐2,5‐dioxopyrrolidin‐3‐yl)propanoate (9), 3‐ethyl‐4‐methylpyrrolidine‐2,5‐dione (10), chiayiensol (11) and chiayiensic acid (12). Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Most of the isolates showed potent inhibitory effects on NO production in LPS‐stimulated RAW 264.7 murine macrophages cells with IC50 values ranging from 9.36 to 40.02 μM. Of these isolates, 4 and 5 showed NO inhibitory activity with IC50 values of 17.14 and 9.36 μM, stronger than the positive control quercetin (IC50=36.95 μM). This is the first report on flavan metabolites from the genus Isoptericola.

show abstract

Secondary metabolites from the fungus Porodaedalea pini

Cited by 3 publications

References 0 publications

Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications

Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

Chemical Constituents from a Mangrove‐Derived Actinobacteria Isoptericola chiayiensis BCRC 16888 and Evaluation of Their Anti‐NO Activity

Contact Info

Product

Resources

About