The fungal plant infection caused by Colletotrichum gloeosporioides known as anthracnose, affects tropical fruits thus causing low yield and poor fruit quality. The antifungal activity of ethanol and chloroform extracts of different Mexican plants jarilla (Baccharis salicifolia), tepozan (Buddleia americana), nanche (Byrsonima cordata), cinco negritos (Lantana camara), Mexican oregano (Lippia berlandieri var. Scanner), and pericon (Tagetes lucida) against C. gloeosporioides were evaluated by determining the minimum inhibitory concentration (MIC) of the ethanol and chloroform extracts. Subsequently, an antifungal assay was carried out by determining the inhibition of radial growth in PDA plates added with plant extracts. Jarilla, oregano, and pericon MIC values were 400 mg/L for ethanol extracts and 200 mg/L for chloroform extracts. Tepozan, nanche, and cinco negritos showed no antifungal effect. Concerning the inhibition of radial growth, pericon ethanol extract showed an 84% inhibition; chloroform extracts of jarilla, oregano, and pericon showed 88%, 90%, and 95% inhibition, respectively. The ethanol extracts of oregano and jarilla demonstrated to be inhibitory at the reproductive phase of C. gloeosporioides, while their chloroform extracts have a fungistatic effect.