Secondary Metabolites Isolated from the Gorgonian-Derived Fungus Aspergillus ruber and Their Antiviral Activity

Liang, Ting-Mei; Fang, Yiwu; Zheng, Jianyi; Shao, Chang‐Lun

doi:10.1007/s10600-018-2406-z

Cited by 20 publications

(16 citation statements)

References 10 publications

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“…Structures of the isolated metabolites were elucidated through extensive MS and NMR spectral analyses (Figures S1–S14, Supplementary Materials), as well as comparison of their spectral data to those reported in the literature [20,28].…”

Section: Methodsmentioning

confidence: 99%

Marine Fungi from the Sponge Grantia compressa: Biodiversity, Chemodiversity, and Biotechnological Potential

et al. 2019

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The emergence of antibiotic resistance and viruses with high epidemic potential made unexplored marine environments an appealing target source for new metabolites. Marine fungi represent one of the most suitable sources for the discovery of new compounds. Thus, the aim of this work was (i) to isolate and identify fungi associated with the Atlantic sponge Grantia compressa; (ii) to study the fungal metabolites by applying the OSMAC approach (one strain; many compounds); (iii) to test fungal compounds for their antimicrobial activities. Twenty-one fungal strains (17 taxa) were isolated from G. compressa. The OSMAC approach revealed an astonishing metabolic diversity in the marine fungus Eurotium chevalieri MUT 2316, from which 10 compounds were extracted, isolated, and characterized. All metabolites were tested against viruses and bacteria (reference and multidrug-resistant strains). Dihydroauroglaucin completely inhibited the replication of influenza A virus; as for herpes simplex virus 1, total inhibition of replication was observed for both physcion and neoechinulin D. Six out of 10 compounds were active against Gram-positive bacteria with isodihydroauroglaucin being the most promising compound (minimal inhibitory concentration (MIC) 4–64 µg/mL) with bactericidal activity. Overall, G. compressa proved to be an outstanding source of fungal diversity. Marine fungi were capable of producing different metabolites; in particular, the compounds isolated from E. chevalieri showed promising bioactivity against well-known and emerging pathogens.

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Section: Methodsmentioning

confidence: 99%

Marine Fungi from the Sponge Grantia compressa: Biodiversity, Chemodiversity, and Biotechnological Potential

et al. 2019

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“…In the study by Huang et al (2017), three anthraquinones were found to have antiviral effects against HSV-1 in vitro using Vero cells. Another fungus of the Aspergillus genus showed antiviral activity against HSV-1, with two secondary metabolites flavoglaucin and isodihydroauroglaucin derived from A. ruber being assessed, and two compounds showing anti-HSV-1 effects (Figure 1) (Liang et al, 2018). In another study, peptides produced by the marine-derived fungus Scytalidium were found to have antiviral activity against HSV-1 and HSV-2, particularly by a peptide named Halovir, which was suggested to have virucidal activity when in direct contact with HSV-1 and HSV-2 (Figure 1) (Rowley et al, 2003).…”

Section: Fungus-derived Compounds With Antiviral Activity Against Hsvmentioning

confidence: 99%

Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

et al. 2020

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Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent within the human population and are characterized by lifelong infections and sporadic recurrences due to latent neuron infection. Upon reactivations, HSVs may manifest either, symptomatically or asymptomatically and be shed onto others through mucosae body fluids. Although, HSVs can produce severe disease in humans, such as lifethreatening encephalitis and blindness, the most common symptoms are skin and mucosal lesions in the oro-facial and the genital areas. Nucleoside analogs with antiviral activity can prevent severe HSV infection, yet they are not very effective for treating skin manifestations produced by these viruses, as they only reduce in a few days at most the duration of lesions. Additionally, HSV variants that are resistant to these antivirals may arise, especially in immunosuppressed individuals. Thus, new antivirals that can reduce the severity and duration of these cutaneous manifestations would certainly be welcome. Here, we review currently available anti-herpetic therapies, novel molecules being assessed in clinical trials and new botanical compounds reported in the last 20 years with antiviral activities against HSVs that might represent future treatments against these viruses.

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“…In the present work, nine compounds were isolated from the ethyl acetate extract of the Aspergillus sp. FRIZ12 biomass, namely: 2benzyl-4H-pyran-4-one (1), flavasperone (2), 5-(hydroxymethyl) furfural (3), uridin (4), ergosterol (5), ergosterol peroxide (6), cerivisterol (7), sitosterol (8), and stigmasterol (9). Compound 1 is reported for the first time in the genus Aspergillus and for the second time as a natural product.…”

Section: Isolated Compoundsmentioning

confidence: 99%

“…14 In turn, compound 4 has been identified as nucleoside uridine; 15 previous works have shown that uridine has antiviral activity. 16 The sterols ergosterol (5), ergosterol peroxide (6), cerivisterol (7), sitosterol (8), and stigmasterol (9) were isolated by chromatographic procedures and identified by NMR and with literature data. [17][18][19] Analysis of the control extracts by MS showed the absence of the isolated compounds in the culture medium, confirming that the isolated compounds are secondary metabolites produced by the fungus Aspergillus FRIZ12 and not from the culture medium.…”

Section: Isolated Compoundsmentioning

confidence: 99%

“…4 Obtaining fungal compounds has been an important strategy for the discovery of new bioactive compounds, since it is known that the fungi are great producers of secondary metabolites, many of them being biologically active. [5][6][7][8][9] Thus, the present work aimed at obtaining compounds with antimicrobial activity from the fungus Aspergillus sp. FRIZ12, in addition to studying their chemistry.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents and Antimicrobial Activity of Soil Fungus Aspergillus sp. FRIZ12

et al. 2018

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Constituintes Químicos e Atividade Antimicrobiana do Fungo de Solo Aspergillus sp. FRIZ12 Resumo: O presente trabalho relata o isolamento de nove compostos da biomassa do fungo de solo Aspergillus sp. FRIZ12. Os compostos 2-benzil-4H-piran-4-ona (1), flavasperona (2), 5-(hidroximetil) furfural (3), uridina (4), ergosterol (5), peróxido de ergosterol (6), cerivisterol (7), estigmasterol (8) e sitosterol (9) foram isolados por métodos cromatográficos, e as estruturas foram identificadas por RMN, EM e comparação com dados da literatura. O composto 1 está sendo relatado pela primeira vez no gênero Aspergillus e pela segunda vez como um produto natural. Os compostos 1 e 2 mostraram moderada atividade antimicrobiana

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Secondary Metabolites Isolated from the Gorgonian-Derived Fungus Aspergillus ruber and Their Antiviral Activity

Cited by 20 publications

References 10 publications

Marine Fungi from the Sponge Grantia compressa: Biodiversity, Chemodiversity, and Biotechnological Potential

Marine Fungi from the Sponge Grantia compressa: Biodiversity, Chemodiversity, and Biotechnological Potential

Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection

Chemical Constituents and Antimicrobial Activity of Soil Fungus Aspergillus sp. FRIZ12

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