Secondary Metabolites of aBruguiera sexangula var.Rhynchopetala-Derived FungusPhomopsis longicollaHL-2232

宋鑫明,; 周学明,; 李小宝,; 郑彩娟,; 黄国雷,; 余章昕,; 宋小平,; 陈光英,

doi:10.6023/cjoc201505044

Cited by 5 publications

(3 citation statements)

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“…The diversity of diterpenoids in plants playing important roles in plant development, stress resistance, and interactions with environmental microorganisms, depends on the various skeletons biosynthesized by terpene synthases and the substrate promiscuity of cytochrome P450 monooxygenases (P450s), along with other postmodification enzymes [38]. In the genus Bruguiera, researchers have isolated five different skeletal types of diterpenoid (Table 2 and Figure 3), namely ent-pimarane (79-82), isopi-marane (83)(84), ent-beyerane (85-86), ent-kaurane (62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78), and ent-gibberellane (59-61), with the key intermediate pimarane in their biosynthesis. Most sesterpenoids are sourced from marine organisms, with approximately 15% of these compounds having been isolated from plants [44].…”

Section: Diterpenoidsmentioning

confidence: 99%

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Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review

Luo,

Chen,

Zhang

et al. 2024

Marine Drugs

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The genus Bruguiera, a member of the Rhizophoraceae family, is predominantly found in coastal areas as a mangrove plant, boasting a rich and diverse community of endophytes. This review systematically compiled approximately 496 compounds derived from both the Bruguiera genus and its associated endophytes, including 152 terpenoids, 17 steroids, 16 sulfides, 44 alkaloids and peptides, 66 quinones, 68 polyketides, 19 flavonoids, 38 phenylpropanoids, 54 aromatic compounds, and 22 other compounds. Among these, 201 compounds exhibited a spectrum of activities, including cytotoxicity, antimicrobial, antioxidant, anti-inflammatory, antiviral, antidiabetic, insecticidal and mosquito repellent, and enzyme inhibitory properties, etc. These findings provided promising lead compounds for drug discovery. Certain similar or identical compounds were found to be simultaneously present in both Bruguiera plants and their endophytes, and the phenomenon of their interaction relationship was discussed.

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Section: Diterpenoidsmentioning

confidence: 99%

“…189(2S,2′R,3R,4E,8E,3′E)-2-(2′-hydroxy-3′octadecenoylamino)-9-methyl-4,8-octadecadiene-l,3-diol P. longicolla HL-2232 (the leaf B. sexangula var. rhynchopetala, endophytic fungus)[67] …”

mentioning

confidence: 99%

Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review

Luo,

Chen,

Zhang

et al. 2024

Marine Drugs

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“…rhynchopetala . The compounds 20 and 21 exhibited cytotoxicity against MCF-7 and A549 cell lines with IC 50 values of 14.9 and 8.6 μM, respectively [ 23 ].…”

Section: Bioactive Compounds In Mangrove Plantsmentioning

confidence: 99%

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

Deshmukh

Gupta

Prakash

et al. 2018

JoF

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Cancer is the second leading cause of death worldwide, and the number of cases is increasing alarmingly every year. Current research focuses on the development of novel chemotherapeutic drugs derived from natural as well as synthetic sources. The abundance and diversity in natural resources offer tremendous potential for the discovery of novel molecules with unique mechanisms for cancer therapy. Mangrove-derived fungi are rich source of novel metabolites, comprising novel structure classes with diverse biological activities. Across the globe, coastal areas are primarily dominated by mangrove forests, which offer an intensely complex environment and species that mostly remain unexplored. In recent years, many structurally diverse compounds with unique skeletons have been identified from mangrove fungi and evaluated for their antiproliferative properties. These compounds may serve as lead molecules for the development of new anticancer drugs. Mangrove endophytes can be modulated using epigenetic means or culture optimization methods to improve the yield or to produce various similar analogs. The present review provides an insight into the bioactive metabolites from mangrove endophytes reported during the period from 2012 to 2018 (up to April, 2018) along with their cytotoxic properties, focusing on their chemical structures and mode of action, as indicated in the literature.

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Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Secondary Metabolites of aBruguiera sexangula var.Rhynchopetala-Derived FungusPhomopsis longicollaHL-2232

Cited by 5 publications

References 5 publications

Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review

Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

Marine natural products

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