Secondary Metabolites of Mushrooms: A Potential Source for Anticancer Therapeutics with Translational Opportunities

Nandi, Sudeshna; Sikder, Rimpa; Acharya, Krishnendu

doi:10.1007/978-981-13-9349-5_23

Cited by 4 publications

(4 citation statements)

References 131 publications

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“…Another mushroom Paxillus panuoides was also reported to yield two ergosteroid compounds: 5α, 8α-epidioxy-(22E, Alkaloids like cocaine, caffeine, nicotine, and theobromine have stimulant activities, whereas some alkaloids such as atropine and tubocurarine are toxic too. Tricholoma terreum possesses a rare 10 ring structured alkaloid that has been extracted from its fruiting bodies and is named terreumols 35 .…”

Section: Steroidsmentioning

confidence: 99%

Untitled

2021

IJPSR

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Since ancient times, humans have always been captivated by nature and have explored natural products. To combat against novel emerging and reemerging diseases and tremendous side effects imposed by recent therapies, scientists have again taken an interest in natural resources. To date, plants have been the major source of natural bioactive compounds, but recently fungi have got more attention. Amongst fungi, edible and medicinal mushrooms have come out as a rich source of bioactive metabolites. Since long back, they are being consumed heavily because of their outstanding flavour, aroma, nutritional value, and medicinal properties. Both edible, as well as medicinal mushrooms, synthesize bioactive compounds known as secondary metabolites i.e., polysaccharides, steroids, terpenes as well as peptides. Such metabolites possess many medicinal properties like anti-oxidant, anti-tumor, anti-diabetic, anti-cancer, antiageing, and also anti-obesity. Furthermore, mushroom secondary metabolites are prioritized over other natural compounds due to their non-toxic nature and low or no side effects. This review mainly covers sources and types of secondary mushroom metabolites and their therapeutic applications.

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Section: Steroidsmentioning

confidence: 99%

Untitled

2021

IJPSR

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“…Although WRF have been extensively studied for their bioremediation capacities, little attention has been given to explore their potential for producing secondary metabolites. Different species of Panus have been found to produce diverse secondary metabolites, such as epoxy compound derivatives of quinones [ 19 , 20 ], sesquiterpenes [ 21 ], and other bioactive substances [ 22 ]; however, there are relatively few studies on their pharmacological properties and potential health benefits. Panepoxydone, a compound previously reported in Lentinus crinitus , was also found in P. conchatus and P. rudis and can interfere with the NF-κB mediated signal, which promotes tumor growth by inhibiting the phosphorylation of IκBα [ 19 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Different species of Panus have been found to produce diverse secondary metabolites, such as epoxy compound derivatives of quinones [ 19 , 20 ], sesquiterpenes [ 21 ], and other bioactive substances [ 22 ]; however, there are relatively few studies on their pharmacological properties and potential health benefits. Panepoxydone, a compound previously reported in Lentinus crinitus , was also found in P. conchatus and P. rudis and can interfere with the NF-κB mediated signal, which promotes tumor growth by inhibiting the phosphorylation of IκBα [ 19 , 23 ]. Another example is hexacyclinol, isolated from the fungal strain P. rudis HKI 0254, which exhibited antiproliferative activity on L-929 cells [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Panapophenanthrin, a Rare Oligocyclic Diterpene from Panus strigellus

Llanos-López,

Ebada,

Vasco-Palacios

et al. 2023

Metabolites

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During the course of our search for biologically active secondary metabolites from fungal cultures, a new oligocyclic diterpenoidal derivative, panapophenanthrin (1), was isolated from Panus strigellus. In addition, two known metabolites, panepophenanthrin (2) and dihydrohypnophilin (3), were also obtained. The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectral analyses together with high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configuration was determined through TDDFT-ECD calculations. All of the compounds were assessed for their antimicrobial and cytotoxic activities. Compounds 1 and 3 showed moderate to weak activities in the performed antimicrobial assays, while compound 1 exhibited potent cytotoxic activity against the mammalian cell lines mouse fibroblast (L929) and human endocervical adenocarcinoma (KB3.1).

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“…Mantarların yapısında bulunan yüksek moleküler ağırlık içeren polisakkaritlerin ve sekonder metabolitlerin monositler, doğal sitolitik lenfositler ve dendritik hücreler gibi doğuştan gelen bağışıklık hücrelerinin üretimi uyararak bağışıklık sistemini güçlendirdiği düşünülmektedir. Mevcut araştırmalar arasında, mantarlardan izole edilen biyoaktif bileşiklerin tümör hücre hatlarının gelişimini inhibe edebildiğinin rapor edildiği birçok çalışma mevcuttur [23,24,25,26]. Ayrıca mantarlar, kanser hastalarında yaygın olarak görülen mide bulantısı, anemi veya halsizlik gibi etkileri azaltabilme özelliklerinden dolayı kanser tedavilerinde alternatif seçenek olarak da görülmektedirler [27].…”

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Mantarlarin Tibbi̇ Özelli̇kleri̇ İle İlgi̇li̇ i̇n Vi̇tro, i̇n Vi̇vo Ve Kli̇ni̇k Değerlendi̇rmeler

Öztürk¹,

Atíla²

2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Amaç: Mantarlar yüzyıllardan beri Uzakdoğu başta olmak üzere tüm dünyada gıda ve tıbbi amaçlı olarak kullanılmaktadır. Dünya genelinde kardiyovasküler hastalıklar, diyabet, kanser, obezite gibi hastalıkların hızla artması ve buna bağlı olarak tedavi ve bakım maliyetlerindeki artışlar, hem araştırıcılar hem de halk arasında alternatif tedavi yöntemlerine olan ilgiyi artmıştır.Sonuç ve Tartışma: In vitro ve in vivo analizler ile klinik çalışmalar, başta Pleurotus spp, Lentinula edodes, Ganoderma lucidum, Grifolia frondosa gibi türler olmak üzere birçok mantar türünün yüzyıllardan beri süregelen geleneksel kullanımlarının doğruluğunu kanıtlamakta ve mantarlardan elde edilen ana biyoaktif bileşiklerin çeşitli hastalıkların önlenmesinde ve tedavisinde bir potansiyele sahip olduklarını göstermektedir. Bu derlemede mantarların, günümüzde sık rastlanan kanser, kardiyovasküler hastalıklar, diyabet gibi hastalıkların önlenmesi ve tedavisindeki potansiyellerini değerlendirmek amacıyla antitümör, antioksidan, antimikrobiyal, kolesterol düşürücü ve kan şekerini düzenleyici etkileri ile ilgili güncel in vitro, in vivo ve klinik çalışmalar derlenmiştir.

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Secondary Metabolites of Mushrooms: A Potential Source for Anticancer Therapeutics with Translational Opportunities

Cited by 4 publications

References 131 publications

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Panapophenanthrin, a Rare Oligocyclic Diterpene from Panus strigellus

Mantarlarin Tibbi̇ Özelli̇kleri̇ İle İlgi̇li̇ i̇n Vi̇tro, i̇n Vi̇vo Ve Kli̇ni̇k Değerlendi̇rmeler

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