Secondary Metabolites with Antinematodal Activity from Higher Plants

Zhou, Ligang; Wang, Jingguo; Wang, Kui; Xu, Jianmei; Zhao, Jianglin; Shan, Tijiang; Luo, Chen

doi:10.1016/b978-0-444-59514-0.00003-1

Cited by 31 publications

(15 citation statements)

References 153 publications

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“…Previously, it has been reported that selected monoterpenes possess antinematodal activities. 18 This preliminary evidence of superior antinematodal activities of 2a and 5a opens up opportunities to develop these safe-to-human molecules as future lead compounds for the control of pine wilt disease.…”

Section: Results and Discussionmentioning

confidence: 92%

Biocatalytic Synthesis of Non-Natural Monoterpene O-Glycosides Exhibiting Superior Antibacterial and Antinematodal Properties

et al. 2019

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A promiscuous Bacillus glycosyltransferase (YjiC) was explored for the enzymatic synthesis of monoterpene O -glycosides in vitro and in vivo. YjiC converted seven monoterpenes into 41 different sugar-conjugated novel glycoside derivatives. The whole-cell biotransformation of the same set of monoterpenes exhibited robust enzyme activity to synthesize O -glucosyl derivatives from Escherichia coli . These newly synthesized selected monoterpene- O -glucosyl derivatives exhibited enhanced antibacterial activities against human pathogenic bacteria and antinematodal activities against pine wood nematode Bursaphelenchus xylophilus .

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Section: Results and Discussionmentioning

confidence: 92%

Biocatalytic Synthesis of Non-Natural Monoterpene O-Glycosides Exhibiting Superior Antibacterial and Antinematodal Properties

et al. 2019

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“…Since the last, comprehensive review of natural products with activity against parasitic nematodes [23], there have been partial revisions on the parasiticidal activities of plant extracts, essential oils and some individual compounds therein [127–129], sometimes focusing on specific parasites [130] or on a particular compound class [131]. Here, we critically appraised the scientific and patent literature for all pure natural compounds active against any parasitic nematode of animals, or against the model nematode C. elegans , from 2010 to 2018, to gain a perspective on the abundance of natural chemical starting points available for anthelmintic drug discovery.…”

Section: Resultsmentioning

confidence: 99%

An appraisal of natural products active against parasitic nematodes of animals

Garcia-Bustos

Sleebs

2019

Parasites Vectors

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Here, the scientific and patent literature on the activities of purified natural compounds has been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery starting points. Only compounds described as active against parasitic nematodes of animals or against the model nematode Caenorhabditis elegans have been analysed. Scientific articles published since 2010 and patents granted from 2000, both inclusive, have been included in this analysis. The results show a scarcity of novel chemical structures, a limited follow-up of compounds disclosed before 2010 and a bias towards the screening of plant products, almost to the exclusion of other sources, when microbial extracts have, historically, provided most starting points for anti-infective drugs. All plant products published in this period were previously known, alerting to the high re-discovery rates of a limited number of chemical classes from this source. The most promising compounds described in the literature reviewed here, namely the linear nemadectin-derivatives, are novel and of bacterial origin. Patented but otherwise unpublished spiroketal structures also appear as interesting scaffolds for future development. The patent literature confirmed that it is possible to patent derivatives of previously known products, making them valid starting points for translational research.

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“…This result strongly suggested that kaempferol contributed to MFM schistosomicidal activity. Braguine et al [ 41 ] showed that this compound is able to separate coupled S. mansoni adult worms and to kill adult schistosomes in vitro at 100 μ M. Also, there are reports on the antihelminthic activity of ursolic acid [ 42 ], but, according to Alvarenga et al [ 43 ], this compound is not active against S. mansoni adult worms. However, it is noteworthy to mention the well-documented hepatoprotective properties of ursolic acid, due to the enhancement of the body defense systems [ 44 ], which might have contributed to the lack of alterations in liver function of infected and noninfected mice treated with MFM.…”

Section: Resultsmentioning

confidence: 99%

Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant SpeciesMitracarpus frigiduson AdultSchistosoma mansoniWorms

Fabri

Aragão

Florêncio

et al. 2014

BioMed Research International

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The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL) for 24 and 48 h and analyzed under an inverted microscope. For the in vivo experiment, mice were inoculated with cercariae and, 20 days after infection, MFM (100 and 300 mg/kg) was administered orally for the following 25 days. Mice were euthanized after 60 days. MFM showed in vitro schistosomicidal activity, exhibiting the opening of the gynaecophoral canal of some male schistosomes, the presence of contorted muscles, vesicles, and the darkening of the paired worms skin. In vivo experiments showed that MFM treatments significantly reduced total worm count, as praziquantel, showing a decrease in liver and spleen weight. Also, a significant reduction in granuloma density was observed. MFM treatment did not cause alterations in the liver function of either infected or noninfected mice. The HPLC chromatogram profile showed the presence of kaempferol-O-rutinoside, rutin, kaempferol, psychorubrin, and ursolic acid.

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Secondary Metabolites with Antinematodal Activity from Higher Plants

Cited by 31 publications

References 153 publications

Biocatalytic Synthesis of Non-Natural Monoterpene O-Glycosides Exhibiting Superior Antibacterial and Antinematodal Properties

Biocatalytic Synthesis of Non-Natural Monoterpene O-Glycosides Exhibiting Superior Antibacterial and Antinematodal Properties

An appraisal of natural products active against parasitic nematodes of animals

Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant SpeciesMitracarpus frigiduson AdultSchistosoma mansoniWorms

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