Secondary Ovarian Malignancies

Waal, Yvonne R. P. de; Thomas, Chris M.G.; Oei, Angèle L.M.; Sweep, Fred C.G.J.; Massuger, Leon F.A.G.

doi:10.1111/igc.0b013e3181b33cce

Cited by 112 publications

(61 citation statements)

References 13 publications

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“…Ovarian metastasis occurs in approximately 3.4% of women diagnosed with a colorectal malignancy 8. However, in up to 38% of cases, ovarian metastasis detection may precede the detection of the primary CRC 9, 10, 11. In such cases, it is important for treatment strategies to recognize that the ovarian tumour is a metastasis and not a primary ovarian tumour.…”

Section: Introductionmentioning

confidence: 99%

Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

Crobach

Ruano

Eijk

et al. 2016

The Journal of Pathology CR

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The mutational profiles of primary colorectal cancers (CRCs) and corresponding ovarian metastases were compared. Using a custom‐made next generation sequencing panel, 115 cancer‐driving genes were analyzed in a cohort of 26 primary CRCs and 30 matching ovarian metastases (four with bilateral metastases). To obtain a complete overview of the mutational profile, low thresholds were used in bioinformatics analysis to prevent low frequency passenger mutations from being filtered out. A subset of variants was validated using Sanger and/or hydrolysis probe assays. The mutational landscape of CRC that metastasized to the ovary was not strikingly different from CRC in consecutive series. When comparing primary CRCs and their matching ovarian metastases, there was considerable overlap in the mutations of early affected genes. A subset of mutations demonstrated less overlap, presumably being passenger mutations. In particular, primary CRCs showed a substantially high number of passenger mutations. We also compared the primary CRCs and matching metastases for stratifying variants of six genes (KRAS, NRAS, BRAF, FBXW7, PTEN and PIK3CA) that select for established (EGFR directed) or future targeted therapies. In a total of 31 variants 12 were not found in either of the two locations. Tumours thus differed in the number of discordant variants between the primary tumours and matching metastases. Half of these discordant variants were definitive class 4/5 pathogenic variants. However, in terms of temporal heterogeneity, no clear relationship was observed between the number of discordant variants and the time interval between primary CRCs and the detection of ovarian metastases. This suggests that dormant metastases may be present from the early days of the primary tumours.

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Section: Introductionmentioning

confidence: 99%

Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

Crobach

Ruano

Eijk

et al. 2016

The Journal of Pathology CR

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“…The most common primary sites are the gastrointestinal tract, breast, and reproductive organs. In Japan, gastric cancer is the most common primary site because of its relatively high prevalence[6]. Pseudo-Meigs’ syndrome is more frequently caused by primary ovarian malignant tumors than ovarian tumors metastases from gastrointestinal cancer, and gastric cancer as the primary source for pseudo-Meigs’ syndrome is particularly rare.…”

Section: Discussionmentioning

confidence: 99%

Case of pseudo-Meigs' syndrome caused by gastric cancer-related metastatic ovarian tumor with prolonged survival

Okamoto

Maeda

Yanagitani

et al. 2016

WJGO

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A 48-year-old woman presented with bilateral enlarged ovaries, ascites, bilateral pleural effusion, and advanced gastric cancer. Pleural fluid cytology did not reveal malignant cells. Oophorectomy, performed as a palliative procedure, was followed by rapid resolution of the pleural effusion and ascites. The patient was diagnosed with pseudo-Meigs’ syndrome, and underwent chemotherapy followed by partial gastrectomy. At the last follow-up, 84 mo following oophorectomy, she was alive, and free of disease recurrence, despite not receiving any further treatment. Pseudo-Meigs’ syndrome should be considered in patients with bilateral ovarian tumors, ascites and pleural effusion, and treatment such as oophorectomy may result in symptomatic improvement and better prognosis in similar patients.

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“…Secondary ovarian tumors, extra-ovarian tumors that spread to the ovary, represent 15% to 20% of ovarian tumors [1, 2]. They may be diagnosed prior to, concurrently with, or after the diagnosis of the primary tumors [3].…”

Section: Introductionmentioning

confidence: 99%

“…They may be diagnosed prior to, concurrently with, or after the diagnosis of the primary tumors [3]. Common extra-ovarian sites of origin of ovarian metastases include the gastrointestinal tract, breast, endocervix, and endometrium [1]. On the other hand, renal cell carcinoma (RCC) usually metastasizes to the lungs, lymph nodes, bones, brain and liver [4], and only very rarely to the ovary or fallopian tube.…”

Section: Introductionmentioning

confidence: 99%

Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases

et al. 2016

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Renal cell carcinoma (RCC), the most common type of kidney cancer in adult, rarely metastasizes to the ovary or fallopian tube, and most cases published in the literature were case reports. Herein, we describe the clinicopathologic features of 9 cases of RCC metastatic to the ovary (n=8) or the fallopian tube (n=1). The patients’ age at the onset of primary renal tumor was available in 8 patients, ranging from 37 to 73 years (mean, 51 years; median, 50 years). Ovarian metastasis was detected prior to or concurrently with the primary renal tumors in 3 patients, and after the diagnosis of renal tumors in 6 patients. The histotypes of the RCCs were clear cell (n=7), chromophobe (n=1), and unclassified (n=1). Immunohistochemical stainings were performed on the sections containing metastatic tumors in 4 cases. Interestingly, pagetoid intraepithelial spread in the tubal mucosa was observed in the case of RCC metastatic to the fallopian tube. Among the 8 patients with follow-up data, 5 patients died of disease and 3 were alive with disease with a follow-up period ranging from 3.7 months to 17 years (mean, 77 months; median, 53 months) after the diagnosis of primary kidney tumors. Diagnostically, metastatic RCC may mimic primary ovarian tumors clinically, morphologically or immunophenotypically. Pathologists should also keep in mind that both ovarian and kidney tumors express PAX8 and PAX2, the markers commonly used to diagnosis metastatic RCC. In addition, chromophobe RCC only rarely metastasizes, but it can be a diagnosis challenging when metastasizing to the ovary.

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Secondary Ovarian Malignancies

Abstract: In case of an ovarian tumor, metastatic disease should always be considered to avoid pitfalls in diagnosis and therapy. The gastrointestinal tract is the most likely location of the primary tumor, followed by breast and endometrium.

Cited by 112 publications

References 13 publications

Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

Case of pseudo-Meigs' syndrome caused by gastric cancer-related metastatic ovarian tumor with prolonged survival

Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases

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