Secondary oxalate nephropathy and kidney transplantation

Aziz, Fahad; Jorgenson, Margaret R.; Garg, Neetika

doi:10.1097/mot.0000000000001035

Cited by 4 publications

(4 citation statements)

References 71 publications

(80 reference statements)

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“…For instance, oxalate exerts negative effect on mineral availability, its presence in food has been reported to cause gut irritation (Ermer et al, 2022) and hinders minerals absorption most especially calcium through formation of insoluble salts with them (Abu Hafsa et al, 2022). Diet with high oxalate content has been reported to increase the risk of renal calcium absorption and may result in kidney stones (Aziz et al, 2022). Similarly, phytate in food is known to form a bond with some essential mineral nutrients in the digestive tract and this will result in mineral deficiencies (Bello et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

DOUM PALM (Hyphaene thebaica) SEED MEAL AS A NOVEL FEEDSTUFF FOR BROILER CHICKENS: EFFECT ON GROWTH RESPONSE

Makinde,

Maidala,

Bagudu

et al. 2023

Trop Subtrop Agroecosyst

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Background. High cost of feed ingredients and increased demand for broiler chicken in many African countries has necessitated the search for alternative feed sources. Objective. To evaluate the effects of Hyphaene thebaica seed meal (HTSM) as substitute for maize on growth and blood parameters of broiler chickens. Methodology. Five experimental diets were formulated for the trial. Diet 1 (0% HTSM) served as the control while diets 2, 3, 4 and 5 contained 5, 10, 15 and 20% HTSM respectively replacing dietary maize in the diets of birds. A total of 225 day-old broiler chicks were randomly allotted into five treatment groups with three replicates of fifteen birds each. Each group was assigned to the five experimental diets in completely randomized design (CRD). Feed and water were supplied ad libitum for all treatment groups during the trial. Result. Differences (P<0.05) were observed in the growth parameters measured except average daily feed intake (P>0.05). Feed conversion ratio and average daily weight gain of birds fed 0, 5 and 10% HTSM diets were better (P<0.05) compared to those fed 15 and 20 % HTSM diets. Differences (P<0.05) were also observed in the blood parameters measured except the packed cell volume (29.08- 31.89%) and mean corpuscular haemoglobin (14.69-15.67pg). The white blood cell (11.45-18.14 x 109/l), red blood cell (4.71-6.99 x 1012/l), haemoglobin (6.92-10.05g/dl) and aspartate transaminase (72.95-90.16 IU/l), alanine aminotransaminase (62.84-79.50 IUu/l) and alkaline phosphatase (100.26-108.77 IU/l) increased (P<0.05) as the dietary levels of HTSM increased across the treatments. Carcass and organ weights of birds fed 0, 5 and 10% HTSM diets were better (P<0.05) than those fed 15 and 20% HTSM diets. Implication. Adequate processing of the HTSM is needed to reduce the anti-nutritional factors to a tolerable level before being used in broiler diet. Conclusion. Broiler chickens can tolerate up to 10% raw HTSM in their diets without adverse effect on growth performance.

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Section: Resultsmentioning

confidence: 99%

DOUM PALM (Hyphaene thebaica) SEED MEAL AS A NOVEL FEEDSTUFF FOR BROILER CHICKENS: EFFECT ON GROWTH RESPONSE

Makinde,

Maidala,

Bagudu

et al. 2023

Trop Subtrop Agroecosyst

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“…Medical management of acute oxalate nephropathy consists of increasing fl uid intake, decreasing dietary oxalate and fat consumption, oral potassium citrate to correct metabolic acidosis and hypocitraturia, and oral calcium carbonate to bind oxalate in the intestinal lumen [12]. Other therapies are under investigation (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Acute post-transplant oxalate nephropathy: A case report and review of the literature

Daniel,

Francois,

Azemi

2024

Arch Organ Transplant

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Calcium oxalate deposition in the kidney allograft remains an underappreciated cause of acute graft dysfunction. Diagnoses such as acute rejection, infection, hydronephrosis, and fluid collections are more immediately considered in the early post-transplant period. Risk factors include hyperoxaluria due to chronic fat malabsorption (post gastric bypass, inflammatory bowel disease), a diet rich in salt or animal protein, vitamin C ingestion, volume depletion, diabetes, and delayed graft function. We present the case of a patient who developed acute kidney injury secondary to oxalate nephropathy at 3 months post-transplant. Renal function improved with medical management, including volume repletion, calcium carbonate, and potassium citrate, without the need for hemodialysis. As more dialysis patients with morbid obesity requiring bariatric surgery, diabetes, and metabolic syndrome are being considered for renal transplantation, this entity merits more careful attention both prior to and after transplantation.

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“…Additionally, there are limited data on traditional ON risk factors associated with fat malabsorption, such as inflammatory bowel disease (IBD), gastric bypass surgery, pancreatic atrophy and small bowel resection in ON after kidney transplantation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Determining the clinical significance of ON may help guide the role of dietary, pharmacologic, and dialysis management after transplantation. Additionally, there are limited data on traditional ON risk factors associated with fat malabsorption, such as inflammatory bowel disease (IBD), gastric bypass surgery, pancreatic atrophy and small bowel resection in ON after kidney transplantation [9–11].…”

Section: Introductionmentioning

confidence: 99%

Oxalate Nephropathy After Kidney Transplantation: Risk Factors and Outcomes of Two Phenotypes

Garg,

Nguyen,

Astor

et al. 2024

Clinical Transplantation

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Describing risk factors and outcomes in kidney transplant recipients with oxalate nephropathy (ON) may help elucidate the pathogenesis and guide treatment strategies. We used a large single‐center database to identify patients with ON and categorized them into delayed graft function with ON (DGF‐ON) and late ON. Incidence density sampling was used to select controls. A total of 37 ON cases were diagnosed between 1/2011 and 1/2021. DGF‐ON (n = 13) was diagnosed in 1.05% of the DGF population. Pancreatic atrophy on imaging (36.4% vs. 2.9%, p = 0.002) and gastric bypass history (7.7% vs. 0%; p = 0.06) were more common in DGF‐ON than with controls with DGF requiring biopsy but without evidence of ON. DGF‐ON was not associated with worse graft survival (p = 0.98) or death‐censored graft survival (p = 0.48). Late ON (n = 24) was diagnosed after a mean of 78.2 months. Late ON patients were older (mean age 55.1 vs. 48.4 years; p = 0.02), more likely to be women (61.7% vs. 37.5%; p = 0.03), have gastric bypass history (8.3% vs. 0.8%; p = 0.02) and pancreatic atrophy on imaging (38.9% vs. 13.3%; p = 0.02). Late ON was associated with an increased risk of graft failure (HR 2.0; p = 0.07) and death‐censored graft loss (HR 2.5; p = 0.10). We describe two phenotypes of ON after kidney transplantation: DGF‐ON and late ON. Our study is the first to our knowledge to evaluate DGF‐ON with DGF controls without ON. Although limited by small sample size, DGF‐ON was not associated with adverse outcomes when compared with controls. Late ON predicted worse allograft outcomes.

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Secondary oxalate nephropathy and kidney transplantation

Cited by 4 publications

References 71 publications

DOUM PALM (Hyphaene thebaica) SEED MEAL AS A NOVEL FEEDSTUFF FOR BROILER CHICKENS: EFFECT ON GROWTH RESPONSE

DOUM PALM (Hyphaene thebaica) SEED MEAL AS A NOVEL FEEDSTUFF FOR BROILER CHICKENS: EFFECT ON GROWTH RESPONSE

Acute post-transplant oxalate nephropathy: A case report and review of the literature

Oxalate Nephropathy After Kidney Transplantation: Risk Factors and Outcomes of Two Phenotypes

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