Secondary Polycythaemia Associated with Unilateral Renal Cystic Disease

Blake-James, Benedict; Attar, Kaka Hama; Rabbani, Sayed Golam; Yeghen, Tullie; Owen, Robert; Peters, John

doi:10.1007/s11255-006-9014-8

Cited by 11 publications

(9 citation statements)

References 8 publications

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“…Arterial oxygen level or oxygen saturation should be normal, excluding hypoxia-driven erythrocytosis. An uncommon, but important etiology of post-transplantation erythrocytosis is renal cell carcinoma affecting the native kidney(s), especially if acquired cystic disease is present and results from constitutive erythropoietin release by carcinoma cells or renal cysts [12,13]. Ureteral stenosis and hydronephrosis may cause erythrocytosis on occasion [13].…”

Section: Post-transplant Erythrocytosismentioning

confidence: 99%

Hematologic abnormalities following renal transplantation

Marinella

2009

Int Urol Nephrol

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Recipients of renal allografts are surviving longer and, consequently, may experience a variety of complications related not only to the transplanted kidney, but also to the hematopoietic system. Common hematologic complications in the renal transplant patient include abnormalities of one cell line, such as post-transplantation erythrocytosis or anemia, that are often treatable with simple measures. Conversely, pathologies involving the leukocyte and platelet population often exist in the context of pancytopenia, which may be a manifestation of systemic infection (e.g., cytomegalovirus, human herpesvirus 8) or malignancy (post-transplantation lymphoproliferative disorders). Uncommon, but life-threatening, processes complicating renal transplantation include hepatosplenic gammadelta T-cell lymphoma and viral-induced hemophagocytic syndrome, both of which are associated with severe pancytopenia and, often, death. Since this patient population is often managed in a multidisciplinary fashion by nephrologists, infection specialists, transplant surgeons, hematologists, and internal medicine physicians, a succinct review of this topic is warranted.

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Section: Post-transplant Erythrocytosismentioning

confidence: 99%

Hematologic abnormalities following renal transplantation

Marinella

2009

Int Urol Nephrol

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“…It is not known whether SRC also may produce EPO. Attar et al [6] showed that patients with unilateral cystic disease as well as patients with ADPKD may have polycythemia. HCT, RBC, and HGB may serve as indirect equivalents of plasma EPO concentration.…”

Section: Discussionmentioning

confidence: 99%

“…However, there might be other indications. It was shown that polycythemia may occur in patients with unilateral cystic disease [6], probably due to production of erythropoietin (EPO) by the cyst wall. This phenomenon was first described in acquired dominant polycystic kidney disease (ADPKD) [7,8].…”

Section: Introductionmentioning

confidence: 99%

Ten-year treatment outcomes including blood cell count disturbances in patients with simple renal cysts

et al. 2013

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BackgroundThe simple renal cyst is the most common benign kidney disease. It may cause pain and hypertension, especially if significantly enlarged. As in polycystic kidney disease, blood cell count disturbances are frequently observed in simple renal cysts. The aim of our study was to assess such disturbances, changes in blood pressure, and complication rate in our patients undergoing surgery due to simple renal cyst in the last 10 years.Material/Methods210 patients with simple renal cysts were underwent surgery between 2002 and 2012. Two different kinds of operation were conducted: aspiration of cyst fluid with injection of sclerosing agent, and laparoscopic/retroperitoneoscopic decortications of the cyst wall. A control group comprised 134 patients with benign prostate hyperplasia. The following data were obtained: cyst burden, hematocrit, hemoglobin, red blood cells, thrombocytes, occurrence of pain, and blood pressure before and after the operation. Complications were collected and presented in Clavien score.ResultsHematocrit, hemoglobin, and red blood cells were significantly increased in the experimental group. A positive correlation was observed between cyst burden and the parameters mentioned above. Of 91 patients with hypertension, 56 (61.7%) had blood pressure reduction after the operation. Treatment relieved the loin pain in 132 (88%) patients. Complications occurred in 15 (7.4%) patients.ConclusionsPatients with simple renal cysts have high values of red blood cells, hematocrit, and hemoglobin. Treatment decreases blood pressure in patients with hypertension. Complications after treatment are rare and mild.

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“…38 Burk at al. Erythrocytosis has also been described in cases of tumors arising in polycystic kidneys 40 and renal cysts, 41 as well as in parathyroid adenoma, 42 pheochromocytoma, 43 hepatocellular adenoma 44 and carcinoma, 45 cerebellar hemangioblastoma 46 and meningiomas. The increase in RCM was associated with an elevation in erythropoietic stimulatory activity in serum, pleural fluid and tumor-cyst fluid supporting the presence of autonomous tumor secretion of Epo or an Epo-like substance.…”

Section: Laboratory Featuresmentioning

confidence: 99%

Erythrocytosis and polycythemia

Walt¹

2011

Blood and Bone Marrow Pathology

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Secondary Polycythaemia Associated with Unilateral Renal Cystic Disease

Cited by 11 publications

References 8 publications

Hematologic abnormalities following renal transplantation

Hematologic abnormalities following renal transplantation

Ten-year treatment outcomes including blood cell count disturbances in patients with simple renal cysts

Erythrocytosis and polycythemia

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