In the industrial production of 6xxx alloys, direct chill (DC) casting is primarily used due to its low cost and high levels of production. However, in conventional DC casting, the 6xxx alloy billet typically has coarse grains and exhibits microstructural inhomogeneity, particularly coarse Fe-containing intermetallics, because of low cooling rate and high Fe impurity. [1-3] To solve these problems, previous work has reported that increasing casting speed (withdrawal speed of billet during DC casting) refined the microstructure and improved the quality of aluminum alloy billets due to increased cooling rates and improved melt flow. [4,5] However, these improvements are limited even if the casting speed rises to 200 mm min À1[4,5] because the cooling rate is limited to 30-40 K s À1. Moreover, Fe acts as a common impurity, forming coarse and brittle Fe-containing intermetallics when Fe levels are higher than 0.2%. Mn addition, [6] severe plastic deformation, [7] melt shearing, [8] and spray forming [9] can relieve its adverse effects, but complexity and high costs restrict their practicality for the industrial production of aluminum alloys. If Fe-containing intermetallics can be effectively refined during DC casting, its adverse effects can be relieved inexpensively in the 6xxx alloy with high Fe levels. However, conventional DC casting cannot effectively refine the Fe-containing intermetallic. [10,11] Therefore, further increases in casting speed and cooling rate are essential for the refinement of Fe-containing intermetallics, grain structures, and improved microstructural inhomogeneity in the industrially produced 6xxx alloy. Until now, the effects of higher casting speed (300 mm min À1) on the grain structure, Fe-containing intermetallics, and microstructural inhomogeneity of 6xxx alloy billets have rarely been investigated. On the contrary, α-dispersoids precipitated during homogenization can obstruct the dislocation motion and control the recrystallization, further improving fatigue strength in deformed 6xxx alloys. [12-14] However, the α-dispersoids are coarse and lower in density in 6xxx alloy billets subjected to conventional casting, suppressing the advantages of α-dispersoids in alloy deformation. [15,16] Current studies focus on the decrease in size and homogeneity of α-dispersoids by changing the heat treatment conditions and alloy composition. [17-19] Regardless, inadequate attention is paid to the effects of as-cast microstructural evolution on the size, morphology, and number density of α-dispersoids. Meanwhile, the air-cooling process after homogenization is considered for the investigation of precipitation behavior of the alloy in industrial production.