Secondary Prevention and Cardiac Rehabilitation

Lo, Hannah; Pazargadi, Aryana; Świątkiewicz, Iwona; Taub, Pam R.

doi:10.1007/978-3-030-56279-3_27

Cited by 2 publications

(14 citation statements)

References 150 publications

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“…CR is a standard of care in CVD patients that aims to improve patient condition, affect modifiable risk factors, and prevent CVD progression or recurrence [6,16,21,22]. CR received the highest class of recommendation for various CVD therapies [16][17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…CR received the highest class of recommendation for various CVD therapies [16][17][18][19][20][21]. While comprehensive ICR is recommended for secondary prevention, exercise-based SCR is still the most common CR modality [6,16,[21][22][23][24][26][27][28][29][30][31]. In addition, a feasibility and effectiveness of various CR programs are uncertain in real-world practice [21][22][23][24][25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac rehabilitation (CR) is recommended as an integral component of secondary prevention [16][17][18][19][20][21]. Exercise training remains the key element of CR; however, comprehensive structured lifestyle interventions are recommended [6,16,21,22]. Diet/nutritional and physical activity counseling, along with weight control, lipid and BP management, and psychosocial interventions are considered as the core components of modern CR programs [21].…”

Section: Introductionmentioning

confidence: 99%

“…Although beneficial effects of CR in CVD patients were demonstrated previously, mostly by small-scale clinical trials and metanalyses, there remains considerable uncertainty regarding the effectiveness of CR in real-world practice, especially in the era of modern evidence-based therapies [22][23][24][25][26]. CR programs vary considerably in intensity, duration, modalities, and delivery.…”

Section: Introductionmentioning

confidence: 99%

“…It is unclear how these variations impact clinical benefits. The feasibility and effectiveness of different types of CR programs have not been well studied, especially in high-risk CVD populations [22][23][24][25][26][27]. Also, comparative analyses of exercise-based standard CR (SCR) and multi-component intensive CR (ICR) in patients with various types of CVD, which could aid in identifying a specific CR program most likely to benefit CVD patients, are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Intensive Cardiac Rehabilitation in High-Risk Patients with Cardiovascular Disease in Real-World Practice

et al. 2021

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Structured lifestyle interventions through cardiac rehabilitation (CR) are critical to improving the outcome of patients with cardiovascular disease (CVD) and cardiometabolic risk factors. CR programs’ variability in real-world practice may impact CR effects. This study evaluates intensive CR (ICR) and standard CR (SCR) programs for improving cardiometabolic, psychosocial, and clinical outcomes in high-risk CVD patients undergoing guideline-based therapies. Both programs provided lifestyle counseling and the same supervised exercise component. ICR additionally included a specialized plant-based diet, stress management, and social support. Changes in body weight (BW), low-density lipoprotein cholesterol (LDL-C), and exercise capacity (EC) were primary outcomes. A total of 314 patients (101 ICR and 213 SCR, aged 66 ± 13 years, 75% overweight/obese, 90% coronary artery disease, 29% heart failure, 54% non-optimal LDL-C, 43% depressive symptoms) were included. Adherence to ICR was 96% vs. 68% for SCR. Only ICR resulted in a decrease in BW (3.4%), LDL-C (11.3%), other atherogenic lipids, glycated hemoglobin, and systolic blood pressure. Both ICR and SCR increased EC (52.2% and 48.7%, respectively) and improved adiposity indices, diastolic blood pressure, cholesterol intake, depression, and quality of life, but more for ICR. Within 12.6 ± 4.8 months post-CR, major adverse cardiac events were less likely in the ICR than SCR group (11% vs. 17%), especially heart failure hospitalizations (2% vs. 8%). A comprehensive ICR enhanced by a plant-based diet and psychosocial management is feasible and effective for improving the outcomes in high-risk CVD patients in real-world practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Intensive Cardiac Rehabilitation in High-Risk Patients with Cardiovascular Disease in Real-World Practice

et al. 2021

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Single chain fragment variable, a new theranostic approach for cardiovascular diseases

Zahid,

Wang,

Cai

et al. 2024

Front. Immunol.

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Cardiovascular diseases (CVDs) remain a significant global health challenge, leading to substantial morbidity and mortality. Despite recent advancements in CVD management, pharmaceutical treatments often suffer from poor pharmacokinetics and high toxicity. With the rapid progress of modern molecular biology and immunology, however, single-chain fragment variable (scFv) molecule engineering has emerged as a promising theranostic tool to offer specificity and versatility in targeting CVD-related antigens. To represent the latest development on the potential of scFv in the context of CVDs, this review summarized the new mechanism of action and applications as therapeutic, as well as diagnostic agents. Furthermore, the advantages of scFv, including its small size, ease of modification, and ability to be engineered for enhanced affinity and specificity, are also described. Finally, such challenges as immunogenicity, stability, and scalability, alongside strategies to overcome these hurdles, are deeply scrutinized to provide safer and more effective strategies for the diagnosis and treatment of the incurable CVDs.

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Secondary Prevention and Cardiac Rehabilitation

Cited by 2 publications

References 150 publications

Effectiveness of Intensive Cardiac Rehabilitation in High-Risk Patients with Cardiovascular Disease in Real-World Practice

Effectiveness of Intensive Cardiac Rehabilitation in High-Risk Patients with Cardiovascular Disease in Real-World Practice

Single chain fragment variable, a new theranostic approach for cardiovascular diseases

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