Secondary Raynaud’s Phenomenon

Ong, Voon H; Denton, Christopher P.

doi:10.1007/978-1-4939-1526-2_8

Cited by 2 publications

(4 citation statements)

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“…Patients with secondary RP often present with more advanced, severe disease and associated complications such as ulceration and gangrene [6,7]. Medical therapy frequently fails to control the symptoms of severe RP and the alternative treatment options are limited.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic sclerosis is the most common cause, with secondary RP occurring in 90% of patients. Secondary RP presents with more severe disease and is more likely to have associated complications such as ulcer and gangrene [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Patients with secondary RP are often a greater clinical challenge. Distal vasospasm can be aggravated by other disease manifestations and also impact on the choice of therapy and responsiveness to vasodilator approaches [6]. Conservative, non-pharmacological measures are usually the first steps in treatment.…”

Section: Introductionmentioning

confidence: 99%

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Optimisation of botulinum toxin type a treatment for the management of Raynaud’s phenomenon using a dorsal approach: a prospective case series

et al. 2019

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Introduction Raynaud's phenomenon (RP) is a common condition and causes pain, paraesthesia, ulceration and gangrene. Botulinum toxin A (Btx-A) is effective when injected via a digital palmar approach, in the treatment of severe RP. However, hand weakness resulting from lumbrical malfunction is a recognized complication. This study aimed to determine the effect of Btx-A injected via a dorsal approach. Method Forty patients received 100 units of Btx-A, injected across both hands via a dorsal approach. Each patient had a baseline, 6-and 12-week hand assessment and thermographic image (FLIR E60bx) performed for the study. Results Eighty-eight percent of patients reported an improvement in symptoms including reduction in pain, improved colour change with reduced swelling and edema at 6 weeks. Of these patients, 80% reported an improvement in cold intolerance with a reduction in the frequency and severity of Raynaud's attacks. There was a significant improvement in both the DASH score (p = 0.001), Kapandji score (p = 0.001) and hand strength (p < 0.05). No patients reported weakness. Improvements in hand function and symptoms of RP were still evident at 12 weeks. Conclusions Btx-A injected via a dorsal approach improves symptoms and reduces the number of RP. We have shown an effective non-surgical approach technique to treat RP. Key Points • Raynaud's phenomenon is a common vasospastic disorder of the digital vessels, which can cause severe pain, restrictions to hand function and ulceration. • Dorsal botulinum toxin type A injections can improve the symptoms of secondary Raynaud's phenomenon and hand function for approximately 3 months.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimisation of botulinum toxin type a treatment for the management of Raynaud’s phenomenon using a dorsal approach: a prospective case series

et al. 2019

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“…Skin blood perfusion and vasodilatation in response to local warming is stimulated by the release of sensory nerve neuropeptides or the non-neural stimulation of the cutaneous arteriole by nitric oxide (NO) [13,14]. Thermographic imagers have exploited this localized warming response to provide a skin blood perfusion challenge [15,16].…”

Section: Introductionmentioning

confidence: 99%

Thermography Quantification of Human Perfusion Thermal Signature

AlZubaidi¹,

Hussein²,

Basil³

et al. 2018

Preprint

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Blood perfusion quantification is important vital parameters in different diagnostic procedure, using infrared thermography imaging; it is reliable to use this technique as non-contact, non-invasive blood flow measurement method. Therefore, we developed a measurement protocol for blood flow over the arm's anterior surface. By using the superficial brachial and radial veins to be monitored under the impact of cold-excitation of (2 °C to 5 °C), the blood perfusion signal was detected using thermal imager of long-wave infrared spectral range (LWIR, 7μm - 14 μm). The simulation of Penne's bioheat transfer equation was performed to be compared with results obtained from the infrared thermography. Furthermore, the proposed blood flow monitoring using external adjusting of the excitation temperature, by using (cold-compress, or cold air-stream) applied to the region under testing. The signal detected resembles to the hemodynamic pulse of the superficial veins, in the definition of systolic and diastolic phases of the cardiac cycle. Moreover, statistical analysis applied to the BFIRT signals from 24 subjects to estimate the skin's mean temperature after recovery from the thermal excitation.

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Secondary Raynaud’s Phenomenon

Cited by 2 publications

References 95 publications

Optimisation of botulinum toxin type a treatment for the management of Raynaud’s phenomenon using a dorsal approach: a prospective case series

Optimisation of botulinum toxin type a treatment for the management of Raynaud’s phenomenon using a dorsal approach: a prospective case series

Thermography Quantification of Human Perfusion Thermal Signature

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