Secondary sclerosing cholangitis following COVID-19 disease: a multicenter retrospective study

Hunyady, Peter; Streller, Lea; Ruether, Darius Ferenc; Groba, Sara Reinartz; Bettinger, Dominik; Fitting, Daniel; Hamesch, Karim; Marquardt, Jens U.; Mücke, Victoria T.; Finkelmeier, Fabian; Sekandarzad, Asieb; Wengenmayer, Tobias; Bounidane, Ayoub; Weiss, Felicitas; Peiffer, Kai-Henrick; Schlevogt, Bernhard; Zeuzem, Stefan; Waidmann, Oliver; Hollenbach, Marcus; Kirstein, Martha M.; Kluwe, Johannes; Kütting, Fabian; Mücke, Marcus M.

doi:10.1016/s0168-8278(22)00993-x

Cited by 5 publications

(4 citation statements)

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“…The underlying histopathological findings consist of ischemic damage to the perihilar bile ducts[ 71 ]. Ursodeoxycholic acid (UDCA) has been reported to give promising results; however, for a proportion of these patients, transplantation is required[ 72 ]. Rare but devastating clinical presentations include liver abscess with necrosis[ 73 ] and vascular thrombotic events in abdominal vessels such as portal and mesenteric vein thrombosis[ 74 ].…”

Section: Critically Ill Patients With Acute Liver Disease and Covid-19mentioning

confidence: 99%

Prevention, diagnostic evaluation, management and prognostic implications of liver disease in critically ill patients with COVID-19

Valsamaki¹,

Xanthoudaki²,

Oikonomou³

et al. 2023

World J Clin Cases

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, broke out in December 2019 in Wuhan city of China and spread rapidly worldwide. Therefore, by March 2020, the World Health Organization declared the disease a global pandemic. Apart from the respiratory system, various other organs of the human body are also seriously affected by the virus. Liver injury in patients with a severe form of COVID-19 is estimated to be 14.8%-53.0%. Elevated levels of total bilirubin, aspartate aminotransferase and alanine aminotransferase and low levels of serum albumin and prealbumin are the main laboratory findings. Patients with pre-existing chronic liver disease and cirrhosis are much more prone to develop severe liver injury. This literature review presented the recent scientific findings regarding the pathophysiological mechanisms responsible for liver injury in critically ill patients with COVID-19, the various interactions between drugs used to treat the disease and the function of the liver and the specific tests providing the possibility of early diagnosis of severe liver injury in these patients. Moreover, it highlighted the burden that COVID-19 put on health systems worldwide and its effect on transplant programs and the care provided to critically ill patients in general and particularly to those with chronic liver disease.

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Section: Critically Ill Patients With Acute Liver Disease and Covid-19mentioning

confidence: 99%

Prevention, diagnostic evaluation, management and prognostic implications of liver disease in critically ill patients with COVID-19

Valsamaki¹,

Xanthoudaki²,

Oikonomou³

et al. 2023

World J Clin Cases

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“…The development of biliary injury in patients with COVID-19 represents an important complication, associated with poor prognosis and clinical outcome[ 77 ]. Biliary involvement in patients with COVID-19 often demonstrates clinical and biochemical features similar to sclerosing cholangitis in critically ill patients (SSC-CIP), manifesting as increased cholestasis indexes (GGT and total bilirubin) in patients with prolonged admission to the ICU and no history of biliary or liver disease nor signs of mechanical obstruction[ 77 , 78 ]. Severe cholestasis has been reported in up to 27% of patients with COVID-19 admitted to the ICU[ 79 ].…”

Section: Liver Disease Involvementmentioning

confidence: 99%

Liver involvement in patients with COVID-19 infection: A comprehensive overview of diagnostic imaging features

Ippolito¹,

Maino²,

Vernuccio³

et al. 2023

World J Gastroenterol

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During the first wave of the pandemic, coronavirus disease 2019 (COVID-19) infection has been considered mainly as a pulmonary infection. However, different clinical and radiological manifestations were observed over time, including involvement of abdominal organs. Nowadays, the liver is considered one of the main affected abdominal organs. Hepatic involvement may be caused by either a direct damage by the virus or an indirect damage related to COVID-19 induced thrombosis or to the use of different drugs. After clinical assessment, radiology plays a key role in the evaluation of liver involvement. Ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) may be used to evaluate liver involvement. US is widely available and it is considered the first-line technique to assess liver involvement in COVID-19 infection, in particular liver steatosis and portal-vein thrombosis. CT and MRI are used as second- and third-line techniques, respectively, considering their higher sensitivity and specificity compared to US for assessment of both parenchyma and vascularization. This review aims to the spectrum of COVID-19 liver involvement and the most common imaging features of COVID-19 liver damage.

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“…9 Another retrospective analysis comprising 24 patients with COVID-secondary sclerosing cholangitis showed that the disease shares the same clinical phenotype, course, and risk factors among critically ill patients who develop secondary sclerosing cholangitis. 10 The suggested mechanisms of liver injury in SARS-CoV-2 infection include direct cytotoxicity from active viral replication of SARS-CoV-2 in the liver, immune-mediated liver damage, hypoxic change-induced respiratory failure, vascular changes due to coagulopathy, and druginduced liver injury. 11 The identification of CD3+ T-cells, including CD8+ T-cells, infiltrating the portal area and targeting the biliary epithelial cells, in this case, provides new insight in the pathogenesis of primary biliary cholangitis in patients with SARS-CoV-2 infection.…”

Section: To the Editormentioning

confidence: 99%

Forms of cholangitis to be considered after SARS-CoV-2 infection

et al. 2022

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Secondary sclerosing cholangitis following COVID-19 disease: a multicenter retrospective study

Cited by 5 publications

References 0 publications

Prevention, diagnostic evaluation, management and prognostic implications of liver disease in critically ill patients with COVID-19

Prevention, diagnostic evaluation, management and prognostic implications of liver disease in critically ill patients with COVID-19

Liver involvement in patients with COVID-19 infection: A comprehensive overview of diagnostic imaging features

Forms of cholangitis to be considered after SARS-CoV-2 infection

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