Secondary structure changes of ox-LDL by photoirradiation in an optofluidic resonator

Abstract

Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human health. Many researches indicated that oxidatively modified low-density lipoprotein (ox-LDL) is a key pathogenic factor of atherosclerosis. Here, we report the change of the secondary structure of ox-LDL caused by photoirradiation in an optofluidic resonator. The content ratios of amphipathic α-helices and β-sheets of ox-LDL are changed under laser beam illumination, resulting in an increasing binding rate of ox-LDL and ox-LDL antibodies. Our findings may provide a potential way for clinical atherosclerosis treatment and prompt recovery rate of atherosclerotic cardio-cerebral vascular disease by optical technology and immunotherapy.