Secondary syphilis on a psoriatic patient under cyclosporine: a challenging case

Pinto-Almeida, Teresa; Rosmaninho, Aristóteles; Sanches, Madalena; Alves, Rute; Selores, Manuela

doi:10.1111/j.1365-4632.2011.05418.x

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…[3] There is also a case report of secondary syphilis on a psoriatic patient, presenting with psoriatic flare and infiltrated atypical lesions which was consistent histologically with secondary syphilis. [4] A case of secondary syphilis mimicking palmoplantar psoriasis has been reported in an HIV patient. [5] In our case, patient had history of unprotected sexual contact with multiple sex workers and history of painless ulcer over glans penis that healed without treatment.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Syphilis and Psoriasis

Kumar¹,

Saradha²,

Anandan³

et al. 2016

jemds

102

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Section: Discussionmentioning

confidence: 99%

Coexistence of Syphilis and Psoriasis

Kumar¹,

Saradha²,

Anandan³

et al. 2016

jemds

102

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“…However, if steroids are instituted for treating patients afflicted with membranous glomerulonephritis secondary to syphilis, adverse outcomes may ensue that may advance the stage of syphilis. 35 By suppressing the immune system, steroids can interfere with the natural process of infection-containment, thereby delaying recovery from luetic nephropathy. Thus, it is better to screen for syphilis before initiation of immunosuppressive treatment even among patients with primary membranous glomerulopathy.…”

Section: Discussionmentioning

confidence: 99%

Membranous Glomerulonephritis as an Uncommon Presentation of Secondary Syphilis: A Reminder on Therapeutic Decision-Making in Clinical Practice

Inayat

Almas

Bokhari

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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Membranous glomerulonephritis is one of the common causes of nephrotic syndrome in the adult population. It is idiopathic in the majority of patients, but the secondary forms can be seen in the setting of autoimmune disease, cancer, infection, and following exposure to certain medications. However, subclinical syphilis-related membranous nephropathy remains a particularly rare clinicopathologic entity in modern times. In this article, we chronicle an interesting case of latent syphilis masquerading as membranous glomerulonephritis, which resolved with benzathine penicillin without requiring immunosuppressive treatment. We further supplement this paper with a concise review of the relevant literature that delineates the utility of appropriate antibiotic therapy in the management of luetic membranous nephropathy. Clinicians should remain cognizant of secondary syphilis while evaluating patients for possible glomerulonephritis or those presenting with proteinuria. Additionally, patients with hepatitis B, hepatitis C, and human immunodeficiency virus infections are not infrequently coinfected with Treponema pallidum. Therefore, a high index of suspicion for systemic manifestations of syphilis such as nephrotic syndrome is warranted in the setting of a coinfection. Prompt diagnosis and treatment of syphilis may result in resolution of proteinuria, without the need for standard immunosuppressive therapy commonly used in clinical practice.

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“…It is possible that this association was a coincidence. Syphilis is a sexually transmitted infection transmitted by Treponema pallidum subspecies pallidum , and several dermatological disorders are reported that are accompanied by syphilis [ 6 , 7 ]. Chung et al [ 8 ] found that T. pallidum can stimulate host human fibroblasts to increase the synthesis of matrix metalloproteinase-1 (MMP-1), which may act as a virulence factor of the organism.…”

Section: Discussionmentioning

confidence: 99%

A Case of Annular Elastolytic Giant Cell Granuloma Associated with Syphilis

Zhang

Liu

et al. 2018

Case Rep Dermatol

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Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells. The pathogenesis of the disease is unclear. We report a case of 55-year-old man with AEGCG in association with syphilis, whose condition improved when hydroxychloroquine sulfate and topical tacrolimus were administered over a 2-month period.

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Secondary syphilis on a psoriatic patient under cyclosporine: a challenging case

Cited by 7 publications

References 9 publications

Coexistence of Syphilis and Psoriasis

Coexistence of Syphilis and Psoriasis

Membranous Glomerulonephritis as an Uncommon Presentation of Secondary Syphilis: A Reminder on Therapeutic Decision-Making in Clinical Practice

A Case of Annular Elastolytic Giant Cell Granuloma Associated with Syphilis

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