Secondary Testicular Tumors

Nistal, Manuel; González‐Peramato, Pilar; Paniagua, Ricardo

doi:10.1159/000471566

Cited by 29 publications

(5 citation statements)

References 7 publications

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“…Solid tumors metastatic to the testicles are usually very uncommon. In fact, three autopsy series, published few decades ago, have reported such incidence between 0.06% and 0.47% [14–16]. Another more recent autopsy study on 738 adult male patients with solid malignant neoplasms and mean age of 60 years showed that 5 (0.68%) patients had metastatic deposits within the testicles; the left testicle being more commonly involved, and in one (20%) case, bilateral involvement was seen [17].…”

Section: Discussionmentioning

confidence: 99%

Isolated Testicular Metastasis Diagnosed More than a Decade and a Half Post Primary Treatment for Prostate Cancer

Heidar

Bustros

El-Asmar

et al. 2019

Case Reports in Oncological Medicine

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Prostate cancer is the most common visceral malignancy among men. It rarely metastasizes to the testicles. We herein present the case of a male patient who underwent a radical prostatectomy for a grade group 3 Gleason score 7 (4 + 3) prostate adenocarcinoma followed by adjuvant radiation therapy and continuous androgen deprivation therapy after his first biochemical recurrence. Despite optimal management, prostate-specific antigen (PSA) levels rose back up, upon which a PET/CT 68Gallium scan demonstrated an isolated left testicular lesion that turned out to be of prostatic origin following orchiectomy. Testicular metastases from prostate cancer are of unknown prognosis, and the current treatment modality favors an orchiectomy.

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Section: Discussionmentioning

confidence: 99%

Isolated Testicular Metastasis Diagnosed More than a Decade and a Half Post Primary Treatment for Prostate Cancer

Heidar

Bustros

El-Asmar

et al. 2019

Case Reports in Oncological Medicine

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“…Of these, secondary testicular tumors (aside from leukemia and lymphoma) are extremely rare, accounting for 0.1–2.4% of all testicular tumors 3 . Common primary sites are the prostate, lungs, skin melanoma, colon, and kidneys, which account for approximately 80% of the primary sites 5 . Metastasis derived from bladder UC is seldom reported, with only 12 case reports identified in a literature review of PubMed from 1966 to the present (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Testicular metastasis from urothelial carcinoma of the bladder

et al. 2021

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Introduction Reports of urothelial carcinoma with testicular metastasis are limited and the etiology and prognosis remain unclear. We report a rare case of testicular metastasis derived from bladder urothelial carcinoma. Case presentation A 68‐year‐old man presented with gross hematuria and urinary frequency. Cystoscopy demonstrated an 8‐cm‐sized tumor in the bladder; transurethral resection and magnetic resonance imaging confirmed invasive urothelial carcinoma. Cystoprostatourethrectomy was performed, and the pathological diagnosis was high‐grade muscle‐invasive urothelial carcinoma. Three years later, the patient noticed a left scrotal mass. Left high orchiectomy was performed, and histopathologic examination of the surgical specimen revealed urothelial carcinoma, confirming testicular metastasis derived from bladder cancer. The patient received chemotherapy with gemcitabine and cisplatin and has survived for 7 years since the initial diagnosis without progression. Conclusion Although rare, secondary lesions should be considered for the differential diagnosis of testicular tumors in patients with a history of urothelial carcinoma.

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“…3 Testicular metastasis is usually a representation of a widespread tumour, and is rarely the initial manifestation of the primary tumour. 4 Appetecchia et al . reported a literature review on the common sites of metastatic cancer to the testes.…”

Section: Discussionmentioning

confidence: 99%

“…3 Testicular metastasis is usually a representation of a widespread tumour, and is rarely the initial manifestation of the primary tumour. 4 Appetecchia et al reported a literature review on the common sites of metastatic cancer to the testes. They found that the commonest site of metastatic cancer to the testes was from the prostate followed by melanoma, sarcoma, lung, kidney, bladder and lastly the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

“…However, metastasis to the testes from lymphoid tissue cancers (lymphoma and leukaemia) is fairly common. 4 Possible routes of metastasis to the testes could be through direct extension, a retrograde venous route, through arterial embolism, a retrograde lymphatic route, and an intraductal route via the vas deferens. 6 We report the sixth case of metastatic adenocarcinoma of the oesophagus to the testes.…”

Section: Discussionmentioning

confidence: 99%

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