Secondary tumors of the GI tract: origin, histology, and endoscopic findings

Gilg, M; Gröchenig, H. P.; Schlemmer, Andrea; Eherer, Andreas; Högenauer, Christoph; Langner, Cord

doi:10.1016/j.gie.2018.02.019

Cited by 34 publications

(35 citation statements)

References 27 publications

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“…The most common carcinomas with unknown diagnosis prior to GI involvement were carcinomas of the ovary (38%), prostate (33%) and lung (25%). When the diagnosis was known, the median time from the initial diagnosis to GI involvement varied by tumour type from 1 to 10 years, in agreement with previous studies 3,5–7 . In 13% of patients the endoscopic appearance was either normal or demonstrated non‐specific inflammation.…”

Section: Discussionsupporting

confidence: 88%

“…In a study of 217 secondary tumours of the GI tract from a single institution, Gilg et al . reported that the primary tumour was unknown in 23% of patients and knowledge of pre‐existing malignancy was not mentioned to pathologists in 39% 5 . In our study, a prior diagnosis of carcinoma was unknown in 16% of patients.…”

Section: Discussioncontrasting

confidence: 51%

“…Gilg et al . described the endoscopic findings with histological correlates of secondary tumours of the GI tract diagnosed between 1985 and 2014 5 . However, there are limited contemporary data on the histology of secondary carcinomas from endoscopic biopsies.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies

2020

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Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies Background: Secondary carcinoma involving the gastrointestinal (GI) tract is an uncommon finding in biopsy specimens. The diagnosis can be challenging for tumours mimicking a primary carcinoma and when the clinical context is unknown. Methods and results: A multicentre retrospective study was performed to evaluate the clinical and histological features of a series of secondary carcinoma in GI biopsies. A total of 197 cases from 190 patients (median age = 67 years; 57% females) were reviewed. In 16% of patients, the primary carcinoma was unknown. Most lesions presented endoscopically as mucosal or submucosal masses (58%). In 13%, the endoscopy was non-suspicious for malignancy. The most common tumours were carcinomas of the breast (38%), kidney (13%), lung (12%), prostate (8%) and ovary (7%). The sites of involvement were the stomach (34%), colon (27%), rectum (18%), duodenum (13%), oesophagus (5%), jejunum (3%) and anus (0.5%). Histological patterns of infiltration were mucosal (76%), submucosal (41%), lymphatic (14%), and epithelial colonisation (8%). Submucosal infiltration was found significantly more frequently in carcinomas of the prostate (67%) and lung (62%), compared with carcinomas of the ovary (27%) and breast (23%). Histological obstructive changes were observed in 36% of all cases, with the highest rate in prostate carcinoma (53%) and the lowest rate in kidney carcinoma (8%). Conclusion: Awareness of the main clinical and histological patterns of secondary carcinomas in GI tract biopsies may help pathologists to raise the possibility of this uncommon diagnosis and confirm it with the judicious use of immunohistochemistry.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 51%

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Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies

2020

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“…Extraintestinal metastasis to the small bowel is a rare event most commonly due to malignant melanoma [1]. Other cancers known to metastasize to the small bowel include, lung, breast, and renal neoplasms [2]. Metastasis to the gastrointestinal tract (GIT) from extraintestinal sources resulting in small bowel perforation is an even less common occurrence.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report

Dabek

Bizanti

Thomas

et al. 2020

Cureus

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Metastasis of extra-intestinal carcinoma to the gastrointestinal tract (GIT) is a rare event, most commonly occurring with malignant melanoma. Anti-PD-1 (programmed death-1) immunotherapeutic agents are immune checkpoint inhibitors with proven benefit across multiple cancer types, including squamous cell carcinoma of the head and neck (SCCHN). Here we describe a case of small bowel perforation attributed to a primary SCCHN metastasizing to the GIT in the setting of treatment with PD-1 inhibitors.

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“…Most biopsies of the gastrointestinal system are performed by endoscopic techniques, which allow direct visualization of tumors. 57,58 While commonly performed, endoscopic biopsies are often limited to FNA, due to limitations in equipment size that preclude the use of cutting needles. 59 When FNA is insufficient to provide a diagnosis, imageguided percutaneous core biopsy may have a role.…”

Section: Gastrointestinal Tract Biopsymentioning

confidence: 99%

Image-Guided Percutaneous Biopsy and Drainage of the Abdomen

Arellano

2018

Dig Dis Interv

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Image-guided percutaneous biopsy and abscess drainages are some of the most commonly performed procedures in interventional radiology. With advances in targeted immunotherapies for oncology patients, physicians increasingly depend on the experience and skill of the interventional radiologist to acquire tissue specimens from within the abdomen and pelvis. Furthermore, percutaneous drainage of abdominal and pelvic fluid collections has largely replaced the need for surgical interventions for infected abdominal collections. This review will discuss techniques of image-guided percutaneous abdominal biopsy and drainage.

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Secondary tumors of the GI tract: origin, histology, and endoscopic findings

Cited by 34 publications

References 27 publications

Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies

Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies

Squamous Cell Carcinoma of the Tonsil Causing Small Bowel Perforation in the Setting of Metastasis and Treatment With Programmed Death-1 Inhibitors: A Case Report

Image-Guided Percutaneous Biopsy and Drainage of the Abdomen

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