Time reversal (TR) transmission technology can focus the power of a signal in both time and space domains and reduce signal energy leakage to unintended receivers, making it suitable for physical layer security systems. By adding a pre-equalizer to the transmitter and optimizing it, the performance of multi-antenna TR transmission system can be improved obviously with an acceptable optimization complexity. In this paper, the pre-equalizer and artificial noise (AN) are jointly optimized to enhance the security performance of pre-equalized TR (ETR) systems when eavesdropping channel state information (ECSI) is unknown or known. When ECSI is unknown, null-space AN is adopted, and the pre-equalizer is optimized to minimize the signal power under the constraint of the minimum signal-to-interference-plus-noise ratio (SINR) of the legitimate receiver. When ECSI is known, under the minimum SINR constraint of the legitimate receiver, the pre-equalizer and AN's covariance matrix are jointly optimized to minimize the SINR of the eavesdropper. The optimization problem is non-convex and is transformed into a convex problem, which can be solved using the CVX toolbox. Simulation results demonstrate that compared with TR systems, by optimizing the pre-equalizer, the security performance of ETR multi-antenna systems can be significantly improved, and the optimization complexity is acceptable.