Secretin Levels in Plasma and Tissue of the Neonatal Swine

Moazam, Farhat; Rodgers, Bryan; Kolts, Byron E.

doi:10.1159/000241568

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Acidification of duodenal contents appears to affect pancreatic exocrine secretion via release of secretin, as elevated serum secretin content has been reported in pigs after intestinal acidification with hydrochloric acid or monocarboxylic acids (Moazam et al, 1982). Biliary secretion is also stimulated via released secretin, regulating glucagon and/or insulin levels (Harada et al, 1986).…”

Section: Resultsmentioning

confidence: 99%

Ileal digestibility of amino acids in pigs fed diets of different buffering capacity and with supplementary organic acids

Mroz¹,

Jongbloed²,

Partanen³

et al. 1998

J. Anim. Feed Sci.

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A 2 x 4 factorial experiment was carried out with eight SICV-cannulated pigs of 30 kg initial BW. Dietary buffering capacity (632 vs 578 meq/kg in Diets H and L, respectively) in combination with supplementary organic acids (formic acid, fumaric acid or n-butyric acid in acid-equivalent doses of 300 mmol/kg) were evaluated for their effects on the apparent ileal digestibility (AID) of protein and amino acids. In the presence of these organic acids in Diet H ("practical"), the AID of crude protein and several amino acids increased by 2.9 to 5.9%-units (PO.05). This increase was linear and positively correlated with increasing dietary acidity. Feeding Diet L without organic acids resulted in an increase of urinary acidity by 1.6 pH-units, and thereby, ammonia emission from manure was 44% lower.

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Section: Resultsmentioning

confidence: 99%

Ileal digestibility of amino acids in pigs fed diets of different buffering capacity and with supplementary organic acids

Mroz¹,

Jongbloed²,

Partanen³

et al. 1998

J. Anim. Feed Sci.

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“…On the other hand, gallbladder mucosa can secrete water and electrolytes into the lumen, and hormones like secretin and vasoactive intestinal peptide not only can inhibit the reabsorption, they can reverse it into a net secretion (20)(21)(22)(23). Since in the early stages of extrauterine life plasma concentrations of secretin and other hormones may exceed adult levels (24)(25)(26), the high concentrations of bicarbonate and chloride in the puppies' gallbladder bile could be due to a hormone-induced inhibition of reabsorption or hormone-induced stimulation of anion secretion. The present results do not allow a rigorous distinction among these mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…In puppies of 0-4 days of age, plasma levels of glucagon are from three to four times higher than those in the adult dog (24). Although secretin plasma levels have not been measured in newborn puppies, data from neonatal swines (26) and human infants (25) have demonstrated a similar age-related change. It is thus possible that spontaneous bile secretion in the newborn dog is maximally stimulated by the high plasma levels of secretin and glucagon, so that administration of exogenous doses of these hormones no longer results in a choleretic response.…”

Section: Bile Acid Choleresis Smallwood El A/ (3) First Demonstratedmentioning

confidence: 94%

Bile Secretion and its Control in the Newborn Puppy

Tavoloni

1986

Pediatr Res

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ABSTRACT. To gain information about the ontogeny of neonatal biliary physiology, we determined gallbladder bile composition, hepatic bile flow and composition, and the choleretic effects of taurocholate, taurodehydrocholate, secretin, and glucagon in anesthetized puppies of 0-3 (n = 13), 7-21 (n = 9), and 28-42 (n = 8) days of age, and in fed (n = 4) and fasted (n = 4) adult dogs. Although gallbladder bile volume was similar in all puppies, chloride concentration in gallbladder bile declined with age (54.2, 33.2, 22.6, 15.9, and 5.8 mEq/liter in these respective groups), and so did bicarbonate concentration (43.5, 26.1, 17.6, 11.4, and 5.7 mEq/liter). In contrast, the concentrations of sodium (175.4, 189.2, 224.5, 251.6, and 279.4 mEq/liter) and bile acids (77.8, 137.3, 206.2, 219.6, and 280.7 mEq/liter) increased. Spontaneous bile flow rate in 0-to 3-day-old puppies averaged 0.194 pl/min/g and increased to 0.365 pl/min/g in puppies of 28-42 days of age. The latter value was not significantly different from that in fed adult dogs (0.344 pl/min/g). '4C-erythritol bile-toplasma ratio in spontaneously secreted bile increased with age (1.05, 1.08, 1.26, 1.48, and 1.70), and chloride concentration decreased (96.8, 85.8, 79.2, 74.3, and 60.1 mEq/ liter). The choleretic activity of taurocholate (2 pmol/min/ kg) was the same in all puppies (7.8 pI/pmol) and adult animals (7.2 pl/pmol). Taurodehydrocholate (2 pmol/min/ kg) increased bile flow by a greater magnitude, yet its choleretic activity in the puppies (13.3 pI/pmol) was the same as that in adult dogs (12.7 pl/pmol). In all animals, total bile acid excretion accounted for 70-95s of the infused taurocholate or taurodehydrocholate. Secretin (1-20 CU/kg/h) and glucagon (1-20 pg/kg/h) produced a minimal, or no effect on bile flow in 0-to 3-day-old puppies. In puppies of 28-42 days of age, the choleretic effect of these hormones was 30-45% of that seen in adult animals. These findings suggest that gallbladder and ductular bile water reabsorption, canalicular secretion, and hormone choleresis are all deficient processes in the newborn puppy and develop during postnatal life. (Pediatr Res 20: 203-208,1986) Abbreviations TC, taurocholate TDHC, taurodehydrocholate B/P, bile-to-plasma ratio

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Effect of secretin on growth of stomach, small intestine, and pancreas of developing rats

1990

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Secretin is present in the intestine of a number of developing species, and plasma secretin levels are elevated in newborn pigs and humans. Secretin stimulates the growth and affects the enzymatic composition of the stomach, small intestine, and pancreas in adult rats. This suggests a possible role for secretin in the rapid postnatal growth of these organs. We investigated this hypothesis by injecting rats subcutaneously with secretin (100 micrograms/kg) every 12 hr for seven days beginning on postnatal day 3, 6, 13, or 24. Growth parameters (weight, content of protein, DNA) as well as the composition of organ-specific enzymes of the stomach, small intestine, and pancreas were measured. Secretin increased growth parameters of the stomach and small intestine in a similar pattern, and in a quantitatively different fashion from that observed in the pancreas. Secretin's effects were also dependent on postnatal age for all organs studied. These data demonstrate that secretin can influence organ growth and enzyme composition of the stomach, small intestine, and pancreas of developing rats and may be one factor regulating growth and development of these organs.

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Secretin Levels in Plasma and Tissue of the Neonatal Swine

Cited by 7 publications

References 11 publications

Ileal digestibility of amino acids in pigs fed diets of different buffering capacity and with supplementary organic acids

Ileal digestibility of amino acids in pigs fed diets of different buffering capacity and with supplementary organic acids

Bile Secretion and its Control in the Newborn Puppy

Effect of secretin on growth of stomach, small intestine, and pancreas of developing rats

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