Secretion in Milk and Transplacental Transfer of Two Iodized Oils, Lipiodol UF&lt;sup&gt;®&lt;/sup&gt; and Oriodol&lt;sup&gt;®&lt;/sup&gt;, in Rabbits

Bourrinet, Philippe; Dencausse, Anne; Cochet, Pascal; Chastin, Isabelle; Bonnemain, Bruno

doi:10.1159/000244441

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…It results in urinary iodine levels above baseline for more than 12 months [41]. In rabbits, Lipiodol crossed the placenta and accumulated in the fetal thyroid [42].…”

Section: Potential Harmful Effectsmentioning

confidence: 99%

The use of iodinated and gadolinium contrast media during pregnancy and lactation

Webb

Thomsen

Morcos³

2004

Eur Radiol

519

180

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The use of iodinated or gadolinium-based contrast media in pregnant or lactating women often causes concerns in the radiology department because of the principle of not exposing a fetus or neonate to any drugs. Because of the uncertainty about the use of contrast media during pregnancy and lactation, the Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and draw up guidelines. An extensive literature search was carried out and summarized in a report. Based on the limited information available, simple guidelines have been drawn up. The report and guidelines were discussed at the 11th European Symposium on Urogenital Radiology in Santiago de Compostela, Spain. Mutagenic and teratogenic effects have not been described after administration of gadolinium or iodinated contrast media. Free iodide in radiographic contrast medium given to the mother has the potential to depress fetal/neonatal thyroid function. Neonatal thyroid function should be checked during the 1st week if iodinated contrast media have been given during pregnancy. No effect on the fetus has been seen after gadolinium contrast media. Only tiny amounts of iodinated or gadolinium-based contrast medium given to a lactating mother reach the milk, and only a minute proportion entering the baby's gut is absorbed. The very small potential risk associated with absorption of contrast medium may be considered insufficient to warrant stopping breast-feeding for 24 h following either iodinated or gadolinium contrast agents.

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“…It results in urinary iodine levels above baseline for more than 12 months [41]. In rabbits, Lipiodol crossed the placenta and accumulated in the fetal thyroid [42].…”

Section: Potential Harmful Effectsmentioning

confidence: 99%

The use of iodinated and gadolinium contrast media during pregnancy and lactation

Webb

Thomsen

Morcos³

2004

Eur Radiol

519

180

View full text Add to dashboard Cite

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“…iodinated fa�y acid esters (IFAE) have been more frequently used during the past decade in the prophylaxis of iodine deficiency in humans. IFAE are applied orally or intramuscularly to populations living in areas affected by endemic goitre (Delange, 1996;Bourrinet et al, 1997;Zimmermann et al, 2000). A single application of iodinated fa�y acid esters provided in humans a long-term protection against health disorders caused by iodine deficiency.…”

Section: Original Papermentioning

confidence: 99%

“…A single application of iodinated fa�y acid esters provided in humans a long-term protection against health disorders caused by iodine deficiency. Oral application of iodinated oil is simpler compared with intramuscular treatment, but the effect is shorter (Bourrinet et al, 1997;Furnee et al, 1997). Data on iodine concentrations in milk of ruminants following application of iodinated fa�y acid esters are only sporadic.…”

Section: Original Papermentioning

confidence: 99%

“…Supported by the Grant Agency of the Ministry of Agriculture of the Czech Republic (Delange, 1996a,b;Bourrinet et al, 1997;Zimmermann et al, 2000, and others). Treatment with a single dose of IFAE provided long-term protection against health disorders due to iodine deficiency.…”

mentioning

confidence: 99%

“…The efficacy of IFAE was sporadically tested in iodine-deficient laboratory and farm animals (Chambon and Chastin, 1993). Administration of IFAE to rabbits demonstrated transplacental passage of iodine and its excretion in milk in pregnant and lactating females, respectively (Bourrinet et al, 1997). Azuolas and Caple (1984) demonstrated significantly higher milk iodine concentrations in sheep 16 months a�er intramuscular administration of a single dose of iodinated oil.…”

mentioning

confidence: 99%

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Milk iodine concentration in cows treated orally or intramuscularly with a single dose of iodinated fatty acid esters

Herzig¹,

Poul²,

Písaříková³

et al. 2003

Vet. Med. - Czech

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ABSTRACT:The effect of a single oral dose of iodinated fa�y acid esters (IFAE) on iodine levels in colostrum and milk of goats was tested. In experimental goats that received a single oral dose of IFAE before delivery, significantly higher iodine levels in milk were recorded 60 days a�er the delivery. In the following period since day 75 a�er the delivery iodine levels decreased, however, remained higher compared to the control, e.g. on day 152 the levels were twice as high as in the controls. Based on these results, the effect of a single oral and parenteral application of IFAE was tested on dairy cows. The results of the experiment showed that a single oral application of IFAE increases milk iodine levels for a shorter period. Intramuscular application resulted in a significantly higher milk iodine levels during the whole experimental period compared to both untreated controls and cows with oral application of IFAE.

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Pregnancy and Lactation: Intravascular Use of Contrast Media

Webb

2014

Medical Radiology

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Secretion in Milk and Transplacental Transfer of Two Iodized Oils, Lipiodol UF<sup>®</sup> and Oriodol<sup>®</sup>, in Rabbits

Cited by 8 publications

References 11 publications

The use of iodinated and gadolinium contrast media during pregnancy and lactation

The use of iodinated and gadolinium contrast media during pregnancy and lactation

Milk iodine concentration in cows treated orally or intramuscularly with a single dose of iodinated fatty acid esters

Pregnancy and Lactation: Intravascular Use of Contrast Media

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