1983
DOI: 10.1084/jem.157.5.1594
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Secretion of a proteolytic anticoagulant by Ancylostoma hookworms.

Abstract: Hookworms of the genus Ancylostoma secrete an anticoagulant that both inhibits the clotting of human plasma and promotes fibrin clot dissolution. This anticoagulant activity is attributable to a 36,000 dalton proteolytic enzyme. The protease can degrade fibrinogen into five smaller polypeptides that intrinsically have anticoagulating properties, covert plasminogen to a mini-plasminogen-like molecule, and hydrolyze a synthetic peptide substrate with specificity for elastolytic enzymes. It is hypothesized that t… Show more

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Cited by 84 publications
(45 citation statements)
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“…Ancylostoma spp., the most common pathogenic hookworm of dog, can cause a daily loss of 0.01 to 0.2 ml of blood for each adult worm, which can result in the daily loss of 25 % or more of the host animal's total blood volume (Miller 1966(Miller , 1971. These findings are also in accordance with the earlier reports i.e., Chattha et al (2009);Cury et al (2002); Okewole et al (2003);Miller (1966Miller ( , 1971; Kelly et al (1977); Hotez and Cerami (1983).…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…Ancylostoma spp., the most common pathogenic hookworm of dog, can cause a daily loss of 0.01 to 0.2 ml of blood for each adult worm, which can result in the daily loss of 25 % or more of the host animal's total blood volume (Miller 1966(Miller , 1971. These findings are also in accordance with the earlier reports i.e., Chattha et al (2009);Cury et al (2002); Okewole et al (2003);Miller (1966Miller ( , 1971; Kelly et al (1977); Hotez and Cerami (1983).…”
Section: Discussionsupporting
confidence: 83%
“…This might be due to loss of blood in dogs affected with hookworm leads to depletion of the body's iron by both the blood sucking habits of the worms, as well as to bleeding of intestinal bite wounds (Hotez and Cerami 1983;Kelly et al 1977). Ancylostoma spp., the most common pathogenic hookworm of dog, can cause a daily loss of 0.01 to 0.2 ml of blood for each adult worm, which can result in the daily loss of 25 % or more of the host animal's total blood volume (Miller 1966(Miller , 1971.…”
Section: Discussionmentioning
confidence: 99%
“…One hundred living, adult-stage A. caninum hookworms were recovered from the intestines of an infected dog at necropsy (6 weeks after infection), as described previously. 16 The adult worms were washed 3 times in sterile phosphate-buffered saline (PBS), then maintained in 15 mL RPMI 1640 containing 25 mM HEPES, 100 U/mL of ampicillin, and 100 g/mL streptomycin at 37°C (5% CO 2 ) for 24 hr. The supernatant was collected, concentrated with PEG6000, and dialyzed against 1 L PBS (pH 7.2) overnight at 4°C.…”
Section: Methodsmentioning
confidence: 99%
“…Proteolytic enzymes have been reported in a number of tissue-penetrating helminths (Mathews 1977;Dresden et al 1985) and endoparasitic insects (Reich and Zorzopulos 1978;Hotez and Cerami 1983). In addition, a collagenase has been isolated from the larvae of Hypoderma lineatum, the warble fly which is endoparasitic on cattle (Lecroisey and KeilI985).…”
Section: Introductionmentioning
confidence: 99%