Secretion of a Salt-Retaining Hormone by the Mammalian Adrenal Cortex

The Action of Cortisone and Desoxycorticosterone Acetate on Glomerular Filtration Rate and Sodium and Water Exchange in the Adrenalectomized Dog

“…In the present studies it has been shown that after cortisone there is still a clear correlation between filtration rate and sodium output, though the latter is slightly less, and the fraction of filtered sodium reabsorbed slightly higher, than at parallel levels of filtration without cortisone. Thus, though cortisone in- 17 Probably aldosterone (34,35).…”

The Aggravating Mechanisms of Aldosterone on Kidney Fibrosis

“…Since its isolation and characterization more than 50 yr ago, 5 investigators have perceived aldosterone primarily as a regulator of extracellular fluid volume and sodium and potassium balance. Aldosterone increases sodium reabsorption in the distal nephron of the kidney by binding to the intracellular mineralocorticoid receptor that translocates to the nucleus, where it upregulates the transcription of genes encoding Na ϩ /K ϩ -ATPase and epithelial sodium channel subunits.…”

The Effect of Changes in Body Sodium on Extracellular Fluid Volume and Aldosterone and Sodium Excretion by Normal and Edematous Men 1

“…The presence of a sodium-retaining hormone, aldosterone, in the adrenal gland and adrenal venous blood (1)(2)(3)(4), the increased urinary excretion of aldosterone during sodium depletion (5,6) and the inability of men and animals with adrenal insufficiency to conserve sodium support the concept that the process by which the sodium content and thus the extracellular fluid (ECF) volume of the body are regulated includes adrenocortical control of sodium excretion by aldosterone secretion (7).…”