Secretion of Inhibin in Female Japanese Quails (Coturnix japonica) from Hatch to Sexual Maturity

Sedqyar, Manila; Wang, Qiang; Watanabe, Gen; Kandiel, Mohamed M.M.; Takahashi, Sinji; Suzuki, Akira; Taneda, Shinji; Taya, Kazuyoshi

doi:10.1262/jrd.19112

Cited by 5 publications

(4 citation statements)

References 49 publications

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“…Previous studies have indicated that inhibins and activins have roles to play in the development and function of the avian gonads during post-hatch prepubertal life [1]. Developmental changes in inhibins have been observed in female Japanese quails, and these observations have shown that plasma ir-inhibins are significantly increased during sexual maturation [35]. In other aves, such as chickens [18,19] and ducks [14,20], there are similar developmental changes in the circulating ir-inhibin concentrations in accordance with the testicular activity.…”

Section: Sedqyar Et Al 104mentioning

confidence: 97%

Secretion of Inhibin in Male Japanese Quail (<i>Coturnix japonica</i>) from One Week of Age to Sexual Maturity

Sedqyar

Wang

Watanabe

et al. 2008

Journal of Reproduction and Development

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Abstract. The objective of this study was to investigate the changes in secretion of inhibin and cellular localization of the inhibin α and inhibin/activin (βA and βB) subunits in male Japanese quail from 1 to 7 weeks after hatching. The posthatch profile of plasma luteinizing hormone (LH), immunoreactive (ir) inhibin and testosterone were measured by radioimmunoassay. Testes were immunostained by the avidin-biotin-peroxidase complex method (ABC) using polyclonal antisera raised against inhibin α, inhibin/activin βA and inhibin/activin βB from one week of age to sexual maturity. Testicular weight increased gradually until 4 weeks and abruptly increased from 5 weeks of age onwards. The plasma concentrations of LH and ir-inhibin increased significantly at 5 weeks of age, and the plasma concentration of testosterone increased significantly at 6 weeks of age. Pituitary contents of LH showed a steady increase until 6 weeks of age and then abruptly increased at 7 weeks of age. Coincident to the increase in plasma testosterone, the testicular contents of testosterone significantly increased from 5 weeks through sexual maturity.Immunohistochemically, localization of the inhibin/activin α, βA and βB subunts was found in the Sertoli and Leydig cells at all ages of development from one week of age to sexual maturity. These results suggest that Sertoli and Leydig cells are the major source of inhibin secretion during development in male Japanese quail. Key words: Inhibin, Japanese quail (Coturnix japonica), Luteinizing hormone (LH), Testes, Testosterone (J. Reprod. Dev. 54: [100][101][102][103][104][105][106] 2008) nhibins and activins are growth and differentiation factors that have been localized in both the reproductive and non-reproductive organs. They exert their effects through both endocrine and local (autocrine/paracrine) mechanisms [1]. Inhibins and activins are structurally related dimeric gonadal proteins with the ability to regulate follicle-stimulating hormone (FSH) secretion from the pituitary glands [2,3]. Inhibin consists of an α subunit linked by a disulfide bridge to one of the 2 highly homologous β subunits (βA and βB) to form inhibin A (α and βA) or inhibin B (α and βB) [4]. In mammalian species, apart from their action on FSH secretion, the inhibins and activins have been shown to exert paracrine/autocrine effects within the gonads [5][6][7][8] and other tissues [9] and have been proposed to have an important paracrine function during testes development [10,11]. In the male, inhibin is produced in the testis, principally by Sertoli cells. There are temporal changes in inhibin expression and secretion with the changing role of the Sertoli cell in immature and adult testes. Variations in inhibins production among species reflect the different patterns of maturation [11][12][13].In avian species, studies have confirmed a mammalian-type endocrine role for inhibins [14][15][16][17]; however, the autocrine/paracrine roles of inhibins and activins in the gonads are still being defined. The profiles of plasm...

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Section: Sedqyar Et Al 104mentioning

confidence: 97%

Secretion of Inhibin in Male Japanese Quail (<i>Coturnix japonica</i>) from One Week of Age to Sexual Maturity

Sedqyar

Wang

Watanabe

et al. 2008

Journal of Reproduction and Development

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“…Inhibin is a glycoprotein hormone consisting of two dissimilar subunits, α and β, that are linked by disulfide bonds and selectively suppresses follicle-stimulating hormone (FSH) secretion [2]. The existence of bioactive inhibin in testis preparations [3,4] and ovarian granulosa cells [5,6] has been reported. The effect of induction of ovarian regression and removal of ovarian follicles on plasma inhibin indicate that the ovary is the major source of inhibin in the hen [7,8].…”

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confidence: 99%

Comparative Changes in the Serum Concentrations of Inhibin-B, Prolactin, Gonadotropins and Steroid Hormones at Different Reproductive States in Domestic Turkey Hens

Khalil

Hanafy

Saleh

et al. 2009

Journal of Reproduction and Development

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Abstract. The present study was undertaken to compare the changes in circulating levels of inhibin-B, prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol-17β, progesterone and testosterone during the different reproductive states of turkey hens. Blood samples were collected during different reproductive states, at laying, incubating and out of lay. Inhibin-B was measured by ELISA, while other hormones were determined by Chemiluminescent Microparticle Immunoassay (CMIA). The results revealed highly significant differences among the hen's states for all serum hormone concentrations. The highest levels of inhibin-B and prolactin were observed in incubating hens, while the lowest values were observed in laying hens. In contrast, the highest levels of FSH, LH, estradiol-17β, progesterone and testosterone were found in the laying group, while the lowest values were found in the incubating group. The progesterone level was higher in the laying group compared with the other groups. These results clearly demonstrate that negative correlation was found between both the inhibin-B and prolactin levels and the gonadotropin and steroid hormone concentrations during the different reproductive states of the turkey hens. In addition, the results suggest that inhibin-B may be involved in control of FSH and LH secretion. . The existence of bioactive inhibin in testis preparations [3,4] and ovarian granulosa cells [5,6] has been reported. The effect of induction of ovarian regression and removal of ovarian follicles on plasma inhibin indicate that the ovary is the major source of inhibin in the hen [7,8]. Prolactin secretion from the avian anterior pituitary gland is principally maintained by tonic stimulation from hypothalamic prolactinreleasing factors [9]. Prolactin secretion markedly changes during the reproductive cycle of the turkey hen. The hyperprolactinemia associated with incubation behavior (broodiness) induces ovarian regression, resulting in a substantial loss of egg production in commercial breeder flocks [10]. Administration of exogenous prolactin suppresses plasma gonadotropins necessary for egg production in domestic fowl [11]. However, there is additional evidence that suppression of gonadotropin secretion in incubating birds also involves a mechanism independent of increased prolactin secretion [12,13]. In turkey hens, the changes in the concentrations of inhibin-B, prolactin, gonadotropins and progesterone have been poorly documented. Therefore, in the present study, we investigated the changes in inhibin-B, prolactin, FSH, luteinizing hormone (LH), estradiol-17β, progesterone and testosterone hormones during the different reproductive states. Materials and Methods Animals and experimental designDomestic turkey hens (local Egyptian strain) were used in the present study. The turkeys were in the first year of production. The hens received a stimulatory photoperiod of 14 h of light:10 h of dark throughout the experimental period and were maintained in floor pens with trap nests. They...

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“…The Japanese quail ( Coturnix japonica ) is considered an ideal biological and experimental model due to its fast development. Quails reach sexual maturity at 6–7 weeks old (Ball and Balthazart 2010 ; Sedqyar et al 2008 ). In the maturing male, testosterone concentrations, testicular weight, and cloacal gland area increase dramatically between 26 and 35 days of age then increase rapidly until sexual maturity.…”

Section: Introductionmentioning

confidence: 99%

Suppressive effects of long-term exposure to P-nitrophenol on gonadal development, hormonal profile with disruption of tissue integrity, and activation of caspase-3 in male Japanese quail (Coturnix japonica)

Ahmed

Nagaoka

Fayez

et al. 2015

Environ Sci Pollut Res

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P-Nitrophenol (PNP) is considered to be one of nitrophenol derivatives of diesel exhaust particles. PNP is a major metabolite of some organophosphorus compounds. PNP is a persistent organic pollutant as well as one of endocrine-disrupting compounds. Consequently, bioaccumulation of PNP potentiates toxicity. The objectives of the current study were to assess in vivo adverse effects of long-term low doses of PNP exposure on reproductive system during development stage. Twnety-eight-day-old male Japanese quails were orally administered different doses of PNP (0, 0.01, 0.1, 1 mg/kg body weight) daily for 2.5 months. Testicular histopathology, hormones, caspase-3 (CASP3), and claudin-1 (CLDN1) tight junction protein, as well as plasma hormones were analyzed. The results revealed that long-term PNP exposure caused testicular histopathological changes such as vacuolation of spermatogenic cell and spermatocyte with significant testicular and cloacal gland atrophy. PNP activated CASP3 enzyme that is an apoptosis-related cysteine peptidase. Besides, it disrupted the expression of CLDN1. Furthermore, a substantial decrease in plasma concentrations of luteinizing hormone (LH) and testosterone was observed after 2 and 2.5 months in the PNP-treated groups. Meanwhile, the pituitary LH did not significantly change. Site of action of PNP may be peripheral on testicular development and/or centrally on the hypothalamic–pituitary–gonadal axis through reduction of pulsatile secretion of gonadotrophin-releasing hormone. Consequently, it may reduce the sensitivity of the anterior pituitary gland to secrete LH. In conclusion, PNP induced profound endocrine disruption in the form of hormonal imbalance, induction of CASP3, and disruption of CLDN1 expression in the testis. Hence, it may hinder the reproductive processes.

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Secretion of Inhibin in Female Japanese Quails (Coturnix japonica) from Hatch to Sexual Maturity

Cited by 5 publications

References 49 publications

Secretion of Inhibin in Male Japanese Quail (<i>Coturnix japonica</i>) from One Week of Age to Sexual Maturity

Secretion of Inhibin in Male Japanese Quail (<i>Coturnix japonica</i>) from One Week of Age to Sexual Maturity

Comparative Changes in the Serum Concentrations of Inhibin-B, Prolactin, Gonadotropins and Steroid Hormones at Different Reproductive States in Domestic Turkey Hens

Suppressive effects of long-term exposure to P-nitrophenol on gonadal development, hormonal profile with disruption of tissue integrity, and activation of caspase-3 in male Japanese quail (Coturnix japonica)

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