2023
DOI: 10.3390/biology12070968
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Secretion of Interleukin 6 in Human Skeletal Muscle Cultures Depends on Ca2+ Signalling

Blanca Calle-Ciborro,
Teresa Espin-Jaime,
Francisco J. Santos
et al.

Abstract: The systemic effects of physical activity are mediated by the release of IL-6 and other myokines from contracting muscle. Although the release of IL-6 from muscle has been extensively studied, the information on the cellular mechanisms is fragmentary and scarce, especially regarding the role of Ca2+ signals. The aim of this study was to characterize the role of the main components of Ca2+ signals in human skeletal muscle cells during IL-6 secretion stimulated by the Ca2+ mobilizing agonist ATP. Primary culture… Show more

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