1977
DOI: 10.1073/pnas.74.8.3542
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Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.

Abstract: In this study we show that T cells from mice infected with Listeria monocytogenes can interact in vitro with normal macrophages to pqoduce a number of soluble mediators, including loymphos imulayinolecules. One of these molecules was a 15,000 dalton protein mitogenic for thymocytes. Generation of mitogenic activity was essentially completed by the first 24 hr of culture and did not require the addition of Listeria antigens. Production of mitogenic protein required contact between the lymphocytes and macrophage… Show more

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Cited by 81 publications
(32 citation statements)
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“…It is generated only after stimulation with mitogen or antigen, and this requires participation by adherent cells, probably macrophages [8]. The A cell-activated T cell interaction is apparently at least partly I-A mediated [25]. A number of alterations known to reduce the immunogenicity of stimulator cells in cell-mediated immunity, including glutaraldehyde fixation [lo] and UV irradiation [ 11,121 , are reversed by adding partially purified 1L2 [16] ; Table I).…”
Section: Discussionmentioning
confidence: 98%
“…It is generated only after stimulation with mitogen or antigen, and this requires participation by adherent cells, probably macrophages [8]. The A cell-activated T cell interaction is apparently at least partly I-A mediated [25]. A number of alterations known to reduce the immunogenicity of stimulator cells in cell-mediated immunity, including glutaraldehyde fixation [lo] and UV irradiation [ 11,121 , are reversed by adding partially purified 1L2 [16] ; Table I).…”
Section: Discussionmentioning
confidence: 98%
“…Thus, the "apparent Kin", i.e., concentration to achieve only half maximal stimulation, would require a 10-fold concentration of the original lymphocyte supernates. One interpretation of this apparent requirement for a very high concentration of lymphocyte factors is that a cell-to-cell (macrophage-lymphocyte) interaction is required for maximal effects, as suggested by Fowles et al (19) for enhancement of macrophage bacteriostasis, and by Farr et al (29) for the stimulated secretion of mitogenic protein by cultures containing T lymphocytes and macrophages. Though this kind of analysis in complex biological systems should be viewed with caution, the observed results indicate that further investigation of the possibility is warranted.…”
Section: Discussionmentioning
confidence: 99%
“…The relationship between IL-l production and the antigen-presenting activity of the macrophage has yet to be critically stud ied. Uptake of some particles, compounds that activate macrophages, and T cell-macrophage interaction during antigen presentation, enhanced IL-I secre tion (136)(137)(138)(139). These observations support the notion that IL-l becomes operative during presentation.…”
Section: Relationship Between Fa Expression and Presentationmentioning
confidence: 99%