Secretion of pancreatic enzymes

Zieve, Leslie; Silvis, Stephen E.; Mulford, Beatrice; Blackwood, William D.; McHale, Ann; Doizaki, William M.

doi:10.1007/bf02239420

Cited by 45 publications

(2 citation statements)

References 17 publications

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“…tions collected by intubation. Pancreatic and biliary secretions were collected after stimulation with secretin and cholecystokinin according to previously described methods (6). In addition, several bone biopsies were obtained from subjects A. and B. from a location 2 cm below either iliac crest.…”

Section: Methodsmentioning

confidence: 99%

Kinetic analysis of lead metabolism in healthy humans.

Rabinowitz¹,

Wetherill²,

Kopple³

1976

J. Clin. Invest.

648

332

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A B S T R A C T The steady state kinetics of lead metabolism were studied in five healthy men with stable isotope tracers. Subjects lived in a metabolic unit and ate constant low lead diets. Their intake was supplemented each day with 79-204 /Ag of enriched lead-204 as nitrate which was ingested with meals for 1-124 days. The concentration and isotopic composition of lead was determined serially in blood, urine, feces, and diet and less commonly in hair, nails, sweat, bone, and alimentary tract secretions by isotopic dilution, mass spectrometric analysis. The data suggest a three-compartmental model for lead metabolism. The first compartment encompasses blood and is 1.5-2.2 times larger than the blood mass. It contains approximately 1.7-2.0 mg of lead and has a mean life of 35 days. This pool is in direct communication with ingested lead, urinary lead, and pools two and three. The second compartment is largely composed of soft tissue, contains about 0.3-0.9 mg of lead, and has a mean life of approximately 40 days. This pool gives rise to lead in hair, nails, sweat, and salivary, gastric, pancreatic, and biliary secretions. Pool three resides primarily in the skeleton, contains the vast quantity of body lead, and has a very slow mean life. Bones appear to differ in their rates of lead turnover. Within the relatively small changes in blood lead observed in the present study, the transfer coefficients between the pools remained constant.

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Section: Methodsmentioning

confidence: 99%

Kinetic analysis of lead metabolism in healthy humans.

Rabinowitz¹,

Wetherill²,

Kopple³

1976

J. Clin. Invest.

648

332

View full text Add to dashboard Cite

show abstract

“…The normal values for volume and bicarbonate concentration are shown in Table 3. (ml) mmol/l Henke et al, 1961 >60 >60 Zieve et al, 1966>80 >70 Hartley et al, 1966 >100 >60…”

Section: Pancreatic Function Testsmentioning

confidence: 99%

Gastric and Pancreatic Function Tests

Bouchier

1970

Ann Clin Biochem

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Laboratory aids to diagnosis—enzymes

Schwartz

1976

Cancer

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A summary is presented of those organ specific enzyme assays traditionally used in evaluation of the patient with cancer. In addition, the use of certain serum enzymes such as gamma-glutamyl transpeptidase, phosphohexose isomerase or 5'-nucleotidase as aids in following the course of the disease, particularly in patients with metastatic spread to the liver is outlined. Also considered is the utility of enzyme analysis in biopsy tissue, biologic fluids, and washings of body cavities. Newer enzymes are considered which might, in the future, be developed as diagnostic tools or as probes for the understanding of the etiology of cancer.

show abstract

Secretion of pancreatic enzymes

Cited by 45 publications

References 17 publications

Kinetic analysis of lead metabolism in healthy humans.

Kinetic analysis of lead metabolism in healthy humans.

Gastric and Pancreatic Function Tests

Laboratory aids to diagnosis—enzymes

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