Sécrétions apocrines dans le tractus génital mâle: Roles potentiels dans la maturation des gamètes

Rejraji, Hanae; Drevet, J. R.

doi:10.1007/bf03035465

Cited by 5 publications

(3 citation statements)

References 124 publications

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“…Within the caput, both apical and principal cells express IDO, and the protein is cytoplasmic. Despite the ability of the caput epithelium to secrete proteins devoid of peptide signal into the duct lumen by the way of apocrine secretion processes (Hermo and Jacks 2002;Frenette et al 2002;Saez et al 2003;Rejraji and Drevet 2004;Sullivan et al 2005), IDO has not been detected in the luminal compartment of the caput epididymidis. Moreover, IDO has not been detected in sperm cells.…”

Section: Discussionmentioning

confidence: 87%

Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis

et al. 2006

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Previous reports have suggested that indoleamine 2,3-dioxygenase (IDO) activity is particularly important in mouse epididymis tissue. We show here, using reverse transcription/polymerase chain reaction assays, Northern assays, Western blotting experiments, and immunohistochemistry that IDO is indeed highly expressed in mouse epididymis, and that IDO mRNA distribution and protein location are precisely regionalized within the organ and within sub-territories of the proximal part of the epididymal duct, the so-called caput epididymidis. Within the caput epididymidis, both the principal and the apical cells have been shown to express IDO. On the contrary, tryptophan dioxygenase (TDO), a sister enzyme of IDO, is weakly and uniformly expressed in mouse epididymis and, in contrast to IDO, is also expressed in testis. In the epididymis, TDO protein expression has been found in a totally different cell type in the smooth muscle layer surrounding the epididymal tubules. Finally, IDO is not secreted into the epididymal lumen, whereas the testis-expressed TDO is present on the head of spermatozoa retrieved from the cauda epididymidis. On the basis of the various functions that have been associated with IDO/TDO, we discuss the putative impacts of IDO/TDO expression on the physiology of mammalian epididymis and spermatozoa.

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Section: Discussionmentioning

confidence: 87%

Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis

et al. 2006

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“…Ces vésicules lipidiques (aussi dénommées génériquement « aposomes » et plus particulièrement « épididymosomes » pour celles dérivant de l'épithélium épididymaire) sont surtout produites par l'épithélium de la tête de l'épididyme (pour revues voir [40,41]). Ces vésicules ont été décrites dans le plasma séminal de plusieurs espèces de mammifères.…”

Section: Remodelage Vésiculaireunclassified

Changes in spermatozoa plasma membrane lipid composition during epididymal maturation

Rejraji¹,

Saez

Drevet

2009

Basic Clin. Androl.

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Un des aspects de la maturation posttesticulaire des spermatozoïdes chez les mammifères est l'évolution progressive de la composition lipidique de la membrane plasmique des gamètes mâles qui permet à ces derniers d'acquérir des capacités fusogènes particulières détermi-nantes pour la fécondation. Une part importante de cette modification du contenu lipidique de la membrane des gamètes mâles est assurée lors de la descente des spermatozoïdes dans le tubule épididymaire. Les mouvements lipidiques seront ensuite poursuivis dans les voies génitales femelles au cours d'un processus dynamique, la capacitation, étape préalable indispensable à la réaction acrosomique, et donc, à la fécondation. Cette revue fait l'état des lieux des connaissances acquises par divers groupes de recherche dans le premier volet épididymaire de la maturation lipidique des gamètes mâles dans différents modèles de mammifères.Abstract One aspect of mammalian post-testicular sperm maturation is the progressive change in their plasma membrane lipid composition. These modifications in lipids allow sperm cells to fuse with oocytes during fertilization. A significant share of these sperm lipid changes occurs during their descent through the epididymal tubule. It then continues within the female genital tract during the capacitation process, an essential prerequisite for acrosomic reaction and hence fertilization. This review presents what is known concerning the sperm plasma membrane lipid changes during epididymal maturation in various mammalian models. In the first section, after a brief presentation of the classic eukaryotic cell plasma membrane lipid organization, the emphasis is on the particularities of sperm plasma membrane lipids. The second section presents the different changes occurring in the three major classes of lipids (i.e. phospholipids, sterols and fatty acids) during the sperm's epididymal descent. The final section briefly describes the mechanisms by which these lipid changes might happen in the epididymal lumen environment. The role played by lipid-rich vesicles secreted by the epididymal epithelium via apocrine secretory processes is highlighted.

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“…In addition, GPx5 is present in the cytoplasm of the epithelium cells in the caput epididymis [25], as well as in the apical cells of the epididymis [27]. The presence of GPx5 has been confi rmed in the free epididymal fl uid, which is considered to be connected to the vesicles rich in lipids, known as epididymosomes [27,28]. Considerable quantities of plasma GPx and GPx3 in the epithelium of the cauda epididymis enable effective protection from damage by ROS [29].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Antioxidants Provided with Feed on Certain Quality Parameters of Bull Semen Under Heat Stress Conditions

et al. 2020

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The aim of the current research was to assess the effects of the feed additive made of lyophilised melon juice (source of superoxide dismutase, SOD) and inactivated live Saccharomyces cerevisiae (strain R397) cells added to the feed via the product containing high levels of organically bound selenium (source of selenium-dependant glutathione peroxidase, Se-GPx) on the semen quality of bulls in heat stress conditions. The 15 bulls chosen for the experiment were assigned to three equal groups (control –group C; treated group M, given the source of SOD; and group A, treated with the source of Se-GPx). The research was conducted in summer. The activities of SOD and Se-GPx in seminal plasma were determined spectrophotometrically. Computer-assisted semen analysis was done to determine the sperm counts, motility and velocity. The temperature and humidity were recorded with a digital data logger.The average SOD activity in the control bulls was significantly lower than in M (p<0.001) and A (p<0.001), whilst the average activities in the treated groups did not differ significantly (p=0.784). Higher average SOD activity compared to the control in the treated groups showed that both feed additives increased the antioxidative capacity of the seminal fluid. The average GPx activity in the control was significantly lower than in groups A (p=0.001) and M (p=0.005), whilst the two treatments did not lead to significantly different results (p=0.701). The analysis of relations between the activity of each enzyme and sperm motility and progressive motility in each of the bulls failed to detect a significant correlation. The analysis of the relation between THI (temperature-humidity index) and the activity of the antioxidative enzymes revealed that the increase in THI coincided with the decrease in the SOD activity in the control group, but with its increase in the treated groups (p>0.05). In all of the three groups with the increase in THI there was an increase in GPx activity (p>0.05). It can be concluded that in all of the three groups of bulls there was an increase in the activity of both enzymes in the seminal plasma, but the increase was significantly lower in the control. Thus, the antioxidative capacity of the seminal plasma of untreated bulls was proven to be lower in comparison with those of the treated animals.

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Sécrétions apocrines dans le tractus génital mâle: Roles potentiels dans la maturation des gamètes

Cited by 5 publications

References 124 publications

Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis

Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis

Changes in spermatozoa plasma membrane lipid composition during epididymal maturation

The Effects of Antioxidants Provided with Feed on Certain Quality Parameters of Bull Semen Under Heat Stress Conditions

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