Abstract:Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive, nerve‐associated tumors and the main cause of death amongst neurofibromatosis type I (NF1) patients. Schwann cells (SCs) are the pathogenic cell type in MPNST, however the secretome of human MPNST ‐derived SCs is poorly defined. In this study, a comprehensive proteomic analysis of the proteins secreted by the sNF96.2 human SC line, derived from a patient with MPNST, was performed using liquid chromatography‐tandem mass spectrometry (LC‐MS… Show more
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