Secretome Analysis Using Affinity Proteomics and Immunoassays: A Focus on Tumor Biology

Beutgen, Vanessa M.; Shinkevich, Veronika; Pörschke, Johanna; Meena, Celina; Steitz, Anna M.; Pogge von Strandmann, Elke; Graumann, Johannes; Gómez-Serrano, María

doi:10.1016/j.mcpro.2024.100830

Molecular & Cellular Proteomics

2024

DOI: 10.1016/j.mcpro.2024.100830

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Secretome Analysis Using Affinity Proteomics and Immunoassays: A Focus on Tumor Biology

Vanessa M. Beutgen,

Veronika Shinkevich,

Johanna Pörschke

et al.

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Cited by 3 publications

References 194 publications

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AI-driven diagnostics and personalized treatment planning in oral oncology: Innovations and future directions

Satheeskumar

2025

Oral Oncology Reports

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AI-driven diagnostics and personalized treatment planning in oral oncology: Innovations and future directions

Satheeskumar

2025

Oral Oncology Reports

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The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends

Geyer,

Hornburg,

Pernemalm

et al. 2024

J. Proteome Res.

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Recent improvements in proteomics technologies have fundamentally altered our capacities to characterize human biology.There is an ever-growing interest in using these novel methods for studying the circulating proteome, as blood offers an accessible window into human health. However, every methodological innovation and analytical progress calls for reassessing our existing approaches and routines to ensure that the new data will add value to the greater biomedical research community and avoid previous errors. As representatives of HUPO's Human Plasma Proteome Project (HPPP), we present our 2024 survey of the current progress in our community, including the latest build of the Human Plasma Proteome PeptideAtlas that now comprises 4608 proteins detected in 113 data sets. We then discuss the updates of established proteomics methods, emerging technologies, and investigations of proteoforms, protein networks, extracellualr vesicles, circulating antibodies and microsamples. Finally, we provide a prospective view of using the current and emerging proteomics tools in studies of circulating proteins.

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Damage of the Bone Marrow Stromal Precursors in Patients with Acute Leukemia at the Onset of the Disease and During Treatment

Sadovskaya,

Petinati,

Shipounova

et al. 2024

IJMS

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In patients with acute leukemia (AL), malignant cells and therapy modify the properties of multipotent mesenchymal stromal cells (MSCs) and their descendants, reducing their ability to maintain normal hematopoiesis. The aim of this work was to elucidate the alterations in MSCs at the onset and after therapy in patients with AL. The study included MSCs obtained from the bone marrow of 78 AL patients (42 AML and 36 ALL) and healthy donors. MSC growth characteristics, gene expression pattern, proteome and secretome were studied using appropriate methods. The concentration of MSCs in the bone marrow, proliferative potential, the expression of several genes, proteomes and secretomes were altered in AL-MSCs. Stromal progenitors had been affected differently in ALL and AML patients. In remission, MSC functions remain impaired despite the absence of tumor cells and the maintenance of benign hematopoietic cells. AL causes crucial and, to a large extent, irreversible changes in bone marrow MSCs.

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Secretome Analysis Using Affinity Proteomics and Immunoassays: A Focus on Tumor Biology

Cited by 3 publications

References 194 publications

AI-driven diagnostics and personalized treatment planning in oral oncology: Innovations and future directions

AI-driven diagnostics and personalized treatment planning in oral oncology: Innovations and future directions

The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends

Damage of the Bone Marrow Stromal Precursors in Patients with Acute Leukemia at the Onset of the Disease and During Treatment

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