2014
DOI: 10.1007/s12015-014-9576-2
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Secretome of Mesenchymal Progenitors from the Umbilical Cord Acts as Modulator of Neural/Glial Proliferation and Differentiation

Abstract: It was recently shown that the conditioned media (CM) of Human Umbilical Cord Perivascular Cells (HUCPVCs), a mesenchymal progenitor population residing within the Wharton Jelly of the umbilical cord, was able to modulate in vitro the survival and viability of different neuronal and glial cells populations. In the present work, we aimed to assess if the secretome of HUCPVCs is able to 1) induce the differentiation of human telencephalon neural precursor cells (htNPCs) in vitro, and 2) modulate neural/glial pro… Show more

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Cited by 107 publications
(85 citation statements)
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“…3A–C,J). This was also noted (with BrdU positive cells) in one of our previous works where we compared injection of MSCs isolated from the umbilical cord tissue or their secretome (CM) into the DG13. Similar effects were also observed regarding neuronal differentiation.…”
Section: Discussionsupporting
confidence: 82%
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“…3A–C,J). This was also noted (with BrdU positive cells) in one of our previous works where we compared injection of MSCs isolated from the umbilical cord tissue or their secretome (CM) into the DG13. Similar effects were also observed regarding neuronal differentiation.…”
Section: Discussionsupporting
confidence: 82%
“…Neurobasal-A medium was then added at the same ratio as the PPRF-msc6. Cells were placed in a humidified incubator at 37 °C and 5% CO 2 , for 24 h. Afterwards, the conditioned medium (CM) was collected as previously described13.…”
Section: Methodsmentioning
confidence: 99%
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“…Rats that were injected with the secretome of hUC mesenchymal progenitors in the hippocampal neurogenic niche displayed similar levels of neural and glial proliferation and differentiation as those injected with parental cells. Moreover, the numbers of doublecortin positive neuronal progenitors in vivo either after MSC or MSC-EV injection were equally increased [56]. Finally, in a rat model of Parkinson’s disease, the secretome of BM-MSCs increased neurogenesis and cell survival and impacted on brain structure and animal behavior [57].…”
Section: Introductionmentioning
confidence: 99%