Secretor status, candidal carriage and candidal infection in patients with diabetes mellitus

Pj, Lamey; Darwaza, A; Fisher, BM; Samaranayake, LP; MacFarlane, T. W.; Frier, B. M.

doi:10.1111/j.1600-0714.1988.tb01549.x

Cited by 82 publications

(72 citation statements)

References 24 publications

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“…Gray et al proposed that there is no correlation between glycemic level and the Candida carriage rate [14]. Yet another study by Lamey et al showed the lack of association between HbA1c or blood glucose level and the Candida carriage rate [15]. Similar reports were also given by Kumar et al who stated that glycemic control and antidiabetic drugs have no correlation with the Candida carriage [16].…”

Section: Discussionsupporting

confidence: 60%

A Study on clinical patterns of mucocutaneous candidiasis in immunosuppressed patients

Subhashini¹

2017

Int J Dermatol Clin Res

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Aim and Objective:This study has been designed to study epidemiology and the common clinical patterns of mucocutaneous candidiasis in immunosuppressed patients. Materials and methods:A cross sectional study on epidemiology and clinical patterns of mucocutaneous candidiasis among 100 immunosuppressed patients of all age groups attending Dermatology OPD in a tertiary care center. Results:Maximum number of patients were in third and fourth decade. Females were more frequently (73%) affected than males (27%). Type 2 diabetes was the most common cause of immunosuppression followed by steroid intake (20%), cancer patients (10%) and HIV (5%). Oral candidiasis was the frequently observed clinical pattern (48%) followed by vulvovaginal candidiasis (45%), intertriginous lesions on the fi ngers (2%), toes (2%), and neck (1%). Balanoposthitis was observed in 2% of patients.Limitation: small sample size. Conclusion:Diabetes was the common cause of immunosuppression. Oral candidiasis was the common clinical pattern observed among them.

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Section: Discussionsupporting

confidence: 60%

A Study on clinical patterns of mucocutaneous candidiasis in immunosuppressed patients

Subhashini¹

2017

Int J Dermatol Clin Res

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“…It was recently noted that epithelial cells from diabetic patients had a higher level of yeast adhesion than cells from nondiabetic controls (Darwazeh e t al., 1990 ; Segal e t al. , 1984), suggesting a correlation between I. POLACHECK a n d O T H E R S the in vitro adhesion ability of the former cells and the known increased susceptibility of these patients to oral, vaginal and cutaneous candidiasis (Lamey et al, 1988;Segal et al, 1984;Segal, 1994;Srebrnik & Segal, 1990). Contrary to this, our study showed no difference in adherence to BECs from diabetics and healthy subjects, questioning the existence of such a correlation.…”

Section: Discussionmentioning

confidence: 99%

Adherence of Candida albicans to epithelial cells: studies using fluorescently labelled yeasts and flow cytometry

Polacheck

Antman²,

Barth³

et al. 1995

Microbiology

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Candida albicans adherence to epithelial cells is the first step in the infectious process, but in Spite O f its importance, CUrTent methods for the quantitative measurement of adherence of C. albicans to epithelial cells in vitm have some serious limitations. They are based on filtration assays and either microscopic or radiometric analysis. The adherence reaction is usually carried out with a large excess of yeasts (100-fold) over epithelial cells in order to perform the microscopic analysis, which is slow# subjective and limited to 100-200 cells and thus lacks statistical power. The radiometric analysis fails to measure individual cells. A method for measuring yeast adherence that overcomes these problems has been developed. It is based on labelling the yeasts with the f luorogenic marker 2',7'-bis-(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester (BCECF) prior to the adherence reaction, and analysing 104 epithelial cells by flow cytometry, while nonbound yeasts are excluded by gating. Two subpopulations of buccal epithelial cells (BECs) which differ in their mean fluorescence intensities per cell (MFls) were observed: one with MFI which did not exceed nonspecific fluorescence, and the other with MFI as high or higher than the MFI of labelled yeasts. The two subpopulations represent yeast-free and yeast-binding epithelial cells, respectively, and the MFI increment of the BECs is a quantitative measure of the extent of yeast adherence. Control experiments confirming previously described basic features of adherence, such as enhanced adherence at increasing yeast excess, diminished adherence of trypsin-treated or heat-inactivated yeasts, and the differential adherence of various Candida species, supported the validity of the assay. The possibility of studying adherence reliably at low yeast:epithelial cell ratios, which better mimic adhesion as it occurs in wiwo, is an important advantage of the assay. New findings, using this method, included the observation that exfoliated BECs from diabetic patients exhibited the same capacity for C. albicans adherence as cells from healthy controls, and that epithelial cells from early human ontogenic stages had a significantly lower adherence level than those from later stages.

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“…Indeed, there are more clinical Candida infections in diabetic patients than non-diabetic individuals (Lamey et al 1988, Darwazeh et al 1990). A high blood glucose level has been shown to associate with candidiasis (Hill et al 1989) and a high salivary glucose level with high salivary yeast counts .…”

Section: Candida Infectionsmentioning

confidence: 99%

Communication and Community

Shepherd¹,

Rothenbuhler²

2000

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Associations have been found between diabetes status and periodontal diseases and dental caries. In addition to biological explanations, psychological features can be proposed to affect the relations between oral health and IDDM (=insulin-dependent diabetes mellitus). The aim of this study was to evaluate the psychological features characterizing oral hygiene practices, dental visiting and diabetes self-care. The research population consisted of 149 IDDM patients, and cross-sectional data were collected by a quantitative questionnaire, in clinical examinations and from patient records.There was a positive correlation between the sum scores for dental self-efficacy and diabetes self-efficacy and, correspondingly, between the dental and diabetes locus of control beliefs. High self-esteem was found to associate with good adherence to some specific health behaviors, such as tooth brushing, exercising and insulin adjustment. When Weiner´s attribution theory was used, there were similarities in the causal thinking in oral and diabetes view. All in all, especially the perception of self-efficacy was found to be a powerful feature characterizing health behavior. There were overlapping relations showing an association of high dental self-efficacy with good diabetes adherence, of high diabetes self-efficacy with frequent dental visiting, and of good metabolic control with high tooth brushing self-efficacy, frequent tooth brushing and low plaque level. On the basis of these results, enhancement of self-efficacy appears important.These results suggest that there might, indeed, be some common psychological features for both oral health behavior and diabetes self-care. These could partly explain the relations between diabetes status and periodontal diseases and dental caries. The results can be utilized in patientcentered health education by identifying and enhancing the psychological features that characterize health behavior and health status. The results emphasize the need for co-operation between dental and diabetes health care professionals in their daily practice.

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Secretor status, candidal carriage and candidal infection in patients with diabetes mellitus

Cited by 82 publications

References 24 publications

A Study on clinical patterns of mucocutaneous candidiasis in immunosuppressed patients

A Study on clinical patterns of mucocutaneous candidiasis in immunosuppressed patients

Adherence of Candida albicans to epithelial cells: studies using fluorescently labelled yeasts and flow cytometry

Communication and Community

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