Secretory Breast Carcinoma With Extensive Intraductal Component: Case Report

Çelik, Alper; Kutun, Suat; Pak, Işın; Seki, Ahmet; Çetin, Abdullah

doi:10.1080/019131290882367

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…Although no cases of MASC with an intraductal growth pattern have been described, it should be noted that only one IDC/LGCCC was included in the control group tested for the ETV6-NTRK3 fusion in Skalova et al's original description of MASC [11]. In addition, secretory carcinoma of the breast with an intraductal component has been reported [12], however without molecular confirmation. For now, the presence of a complete myoepithelial layer around tumor nests is considered specific to IDC/LGCCC amongst salivary carcinomas [2,3,5,8], and is the preferred diagnosis for this tumor.…”

Section: Discussionmentioning

confidence: 99%

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Weinreb

2011

Head and Neck Pathol

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Since the first description of an entirely intraductal epithelial proliferation of salivary gland by Chen in 1983 as an ''intraductal carcinoma'', there have been several dozen reported cases with the same and various additional names including ''low-grade salivary duct carcinoma'', ''low-grade cribriform cystadenocarcinoma'' and ''carcinoma in situ'' of salivary gland. These refer to a combination of nests and cysts of varying size formed by a cellular proliferation resembling atypical ductal hyperplasia or ductal carcinoma in situ of the breast. The lesions are generally entirely intraductal with low, intermediate or high-grade dysplasia. Occasional benign tumors of salivary gland, particularly Warthin tumor and rare salivary carcinomas may arise within an intraparotid lymph node. In addition, intraparotid lymph nodes are a routine location for metastatic disease. A case of a 59-year-old female with a parotid mass is described, which grossly had the appearance of a Warthin tumor. Microscopically, it was an entirely intranodal proliferation of cells with diffuse AE1/ AE3 and S100 positivity. The nests and cysts were completely surrounded by a rim of non-neoplastic myoepithelial cells, which were positive for CK14, p63, SMA, MSA and calponin. The tumor cells were negative for these markers. The cells were only focally positive for AR and BRST-2. They showed negligible MIB-1 staining. This report describes, for the first time, an entirely intranodal location for a low-grade intraductal carcinoma (so-called low-grade cribriform cystadenocarcinoma).

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Section: Discussionmentioning

confidence: 99%

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Weinreb

2011

Head and Neck Pathol

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“…However, subsequent reports suggested that only a third of the published cases occurred in children, and the median age for patients with an SBC is 25 years 1 – 26. SBCs account for <1% of invasive breast carcinomas and are characterised clinically by late local recurrences and prolonged survival even with lymph node involvement 5 7 10 – 12. Distant metastases are exceedingly rare 10.…”

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confidence: 99%

Genomic profile of a secretory breast cancer with anETV6–NTRK3duplication

et al. 2009

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To the best of our knowledge, this is the first time a carcinoma has been shown to harbour a duplication of the ETV6-NTRK3 translocation. The presence of an additional copy of the derivative chromosome der(15)t(12;15) coupled with deletion of the other derivative der(12)t(12;15) in the modal population of cancer cells suggests that this was either an early phenomenon or conferred additional growth advantage on neoplastic cells.

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“…Although intraductal components usually accompany with invasive SBC [5], no research has focused on the in situ lesions of SBC. We reviewed the previous studies of SBC from 1990 to 2018; intraductal secretory carcinoma with invasive components was described in several studies [6–8], with or without specific description of in situ components. Only five cases of pure secretory carcinoma in situ have been reported to our knowledge [9–11], including three cases in a research investigating the expression of STAT 5a which had no clinicpathological details except ages and genders [11], and the significance of this uncommon lesion was not discussed further.…”

Section: Discussionmentioning

confidence: 99%

Pure secretory carcinoma in situ: a case report and literature review

et al. 2019

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Background Secretory breast carcinoma is an exceptionally rare type of breast carcinoma. Only 5 cases of pure secretory carcinoma in situ have been reported in English literature. Herein, we reported a rare case of pure secretory breast carcinoma in situ. Case presentation The patient is a 38-year-old female with bloody discharge from the left nipple. Microscopically, the terminal-duct lobular units were enlarged and filled with tumor cells. The tumor cells were arranged in cystic, microcystic, solid and papillary pattern and formed a honeycomb-like appearance. The presence of intracellular and extracellular eosinphilic PAS-positive material was the most remarkable feature. Immunohistochemically, myoepithelial markers highlighted the complete presence of myoepithelial cells around the tumour nests. Tumour cells were strongly positive for S-100 and CK5/6, negative for ER, PR and HER2. Fluorescence in situ hybridization analysis showed ETV6-NTRK3 fusion. Conclusion Secretory carcinoma in situ shares the same morphological, immunohistochemical and molecular features with invasive secretory carcinoma except that the papillary growth pattern is more common in the introductal components. Cautions should be taken to distinguish secretory carcinoma in situ from other introductal lesions. Our report is an important supplement to the morphology spectrum of secretory breast carcinoma.

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Secretory Breast Carcinoma With Extensive Intraductal Component: Case Report

Cited by 8 publications

References 12 publications

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Genomic profile of a secretory breast cancer with anETV6–NTRK3duplication

Pure secretory carcinoma in situ: a case report and literature review

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