SECRETORY IgA IN SKIN AND THE ADJACENT MUCOUS MEMBRANES

Kaneko, Fumio; Kawagishi, Ikuro; Miura, Yusho; Kobayashi, Kunihiko

doi:10.1111/j.1346-8138.1982.tb02610.x

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…It is not clear that these substances behave in a similar way with viruses. Surface immunoglobulin A has also been shown to contribute to the immunological defense of the skin (23). The presence of two HAV subpopulations in the inocula may also be responsible for the biphasic pattern in virus decay, so that the more susceptible virus population is inactivated faster during the drying period and the more resistant virus population persists over the whole study period (4 h).…”

Section: Frictionmentioning

confidence: 99%

Survival of hepatitis A virus on human hands and its transfer on contact with animate and inanimate surfaces

et al. 1992

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The survival of hepatitis A virus (HAV; strain HM175) on the hands of five volunteers was determined by depositing 10 ,ul of fecally suspended virus on each fingerpad and eluting the inoculum after 0, 20, 60, 120, 180, and 240 min. The amount of virus recovered from each fingerpad at 0 min was approximately 6.0 x 104 PFU. At the end of 4 h, 16 to 30%o of the initially recoverable virus remained detectable on the fingerpads. HAV inocula (10 ,ul; approximately 1.0 x 104 PFU) placed on fingerpads or 1-cm-diameter metal disks were used to determine virus transfer to clean surfaces upon a 10-s contact at a pressure of nearly 0.2 kg/cm2. When the inoculum was dried for 20 min, virus transfer from fingerpad to fingerpad, fingerpad to disk, and disk to fingerpad ranged from 2,667 to 3,484 PFU, while 0 to 50 PFU could be transferred after 4 h of drying. Elevation of the contact pressure alone from 0.2 to 1.0 kg/cm2 resulted in an approximately threefold increase in the amount of virus transferred. Incorporation of friction (10 half turns of the finger during 10 s of contact) with the low and high levels of pressure gave two-and threefold increases in the PFU of virus transferred, respectively. Pressure and friction were found to significantly affect HAV transfer (F = 33.98; P < 0.05), irrespective of the mode of transfer used. No statistically significant interaction was observed between mode of transfer and pressure or friction. The findings of this quantitative study suggest that human hands may play an important role in the direct as well as the indirect spread of HAV.

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Section: Frictionmentioning

confidence: 99%

Survival of hepatitis A virus on human hands and its transfer on contact with animate and inanimate surfaces

et al. 1992

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“…The significance of these proteins in normal human epithelium remains uncertain. In normal skin, secretory IgA has been reported and its relation to the surface immunological defence system of the skin suggested (21). Lai a Fat (22) proposed that immunoglobulins and secretory component:(SCycoula.~nOtbesyni:hesized in normal skin, so we presume that IgA and SC penetrate from the vesselslike other serum proteins.…”

Section: Discussionmentioning

confidence: 79%

Demonstration of Immunoglobulin G in Normal Human Epidermis by Light and Electron Microscopy Using Peroxidase Labeled Antibody

Yamada

1983

The Journal of Dermatology

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Distribution of immunoglobulins in normal human epidermis was revealed at both the light and electron microscopic levels using peroxidase labeled antibodies. Biopsy specimens were obtained from various body locations of 40 healthy persons from 2 to 82 years old under local anesthesia. There were three types of IgG staining patterns in normal human epidermis. Intraepidermal IgG was found in about 80% of the skin samples. IgG was localized in the cytosol of squamous cells by electron microscopy. There were no morphological differences between the IgG positive and IgG negative cells. There seemed to be a correlation between IgG staining and the IgG serum level. The results of the present study suggest that with highly sensitive immunohistochemical techniques, IgG can be detected not only in diseased skin but also in normal skin.in relation to local immunodefence of the skin. MATERIALS AND METHODS

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“…Normal skin tissues taken from 15 healthy controls revealed no deposits of IgA and J chain in the dermis, but in 3 out of them faint deposits of SC were found at the DE junction as described previously [ 10]. On the other hand, the deposits of SC at the DE junction were clearly found in psoriatic skin [9,10].…”

Section: If Findingsmentioning

confidence: 81%

“…On the other hand, the deposits of SC at the DE junction were clearly found in psoriatic skin [9,10].…”

Section: If Findingsmentioning

confidence: 97%

Secretory IgA in Schönlein-Henoch Purpura

Kaneko¹,

Mori²,

Miura³

1984

Dermatology

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2 young patients with Schönlein-Henoch purpura were investigated to detect secretory IgA and secretory component (SC) in skin lesions and urine in connection with the upper respiratory and intestinal symptoms at onset. In these cases, laboratory findings revealed relative leukocytosis, hematuria, and proteinuria in urinalysis, but no elevation of serum immunoglobulin levels and ASO titer. In biopsy specimens from purpuric lesions on lower extremities, leukocytoclastic vasculitis was found in the upper dermis histologically. Immunofluorescence showed deposits of IgG and IgA with SC and joining chain and complement at vessel walls in the upper dermis, and SC was deposited at the dermoepidermal junction. An attempt to concentrate urine from the patients revealed precipitin lines of IgG, IgA, and SC by using Ouchterlony’s method. These observations suggest that in patients with Schönlein-Henoch purpura circulating immune complexes containing secretory IgA and SC deposits in skin lesions and kidney exist in connection with the initial involvements on the mucous membranes of the respiratory and/or intestinal tracts.

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SECRETORY IgA IN SKIN AND THE ADJACENT MUCOUS MEMBRANES

Cited by 9 publications

References 10 publications

Survival of hepatitis A virus on human hands and its transfer on contact with animate and inanimate surfaces

Survival of hepatitis A virus on human hands and its transfer on contact with animate and inanimate surfaces

Demonstration of Immunoglobulin G in Normal Human Epidermis by Light and Electron Microscopy Using Peroxidase Labeled Antibody

Secretory IgA in Schönlein-Henoch Purpura

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