Secretory Immunoglobulin A in Hepatobiliary Diseases

Vuitton, D.; Seillès, Estelle; Cozon, G.; Rossel, Mireille; Bresson‐Hadni, Solange; Revillard, Jean‐Pierre

doi:10.1159/000171295

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…CD57 is known to be expressed by epithelial cell types; however, the immunologic significance of such a strong and concomitant expression, if any, certainly deserves further studies. Similar induction of expression of the polymeric immunoglobulin receptor by bile duct cells has been reported in the past [42,43]. This molecule is also involved in immunologic mechanisms and is expressed in similar circumstances of hepatic stress and chronic cholestasis.…”

Section: Discussionsupporting

confidence: 70%

Expression of Major Histocompatibility Complex Class I Chain–Related Molecule A, NKG2D, and Transforming Growth Factor–β in the Liver of Humans with Alveolar Echinococcosis: New Actors in the Tolerance to Parasites?

et al. 2008

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Section: Discussionsupporting

confidence: 70%

Expression of Major Histocompatibility Complex Class I Chain–Related Molecule A, NKG2D, and Transforming Growth Factor–β in the Liver of Humans with Alveolar Echinococcosis: New Actors in the Tolerance to Parasites?

et al. 2008

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“…The presence of very low amounts of immunoreactive SC with an apparent molecular mass lower than 100 kD in gel chromatography in normal serum has been recently demonstrated (3,4); this molecular mass suggests that it is not bound to dimeric IgA or pentameric IgM, and it thus will be referred to as Ir F-SC. The relationship between increased levels of serum IgA (and particularly S-IgA) and liver diseases is well known (2,5,6). The presence of elevated concentrations of low molecular weight Ir F-SC in the serum has been referred to in patients with cholestasis (6) and has been demonstrated in patients with primary liver carcinoma (7).…”

Section: ~1046-1053)mentioning

confidence: 99%

Serum and bile secretory immunoglobulins and secretory component during the early postoperative course after liver transplantation

Bresson‐Hadni¹,

Rossel

Seillès

et al. 1991

Hepatology

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Secretory component was assayed in serum and bile from 34 patients within 40 days after a first or a second (three cases) liver transplantation. Levels of serum secretory IgA and IgM and of a serum component referred to as immunoreactive free secretory component, identified by its reactivity with monoclonal and polyclonal antibodies specific to secretory component, were significantly elevated in all posttransplant patients compared with 45 healthy subjects and 10 kidney transplant patients (p less than 0.0001). The highest serum levels of bound secretory component and of immunoreactive free secretory component were observed in patients with acute rejection. The elevation of immunoreactive free secretory component was significantly higher in patients with rejection as compared with patients with a graft ischemia (p = 0.002) or an uncomplicated postoperative evolution (p = 0.01). The highest levels of immunoreactive free secretory component and secretory IgM were observed in a transplant patient with selective IgA deficiency. No significant difference was seen between the levels of serum immunoreactive free secretory component observed in patients with rejection and those of patients with cytomegalovirus hepatitis or sepsis. Immunoreactive free secretory component, secretory IgA and secretory IgM levels measured in the serum of three patients with primary nonfunction were lower than those observed in the other groups. Immunoreactive free secretory component bile/serum ratios calculated from 16 patients were significantly higher in patients with acute rejection than in infected patients. This study provides new insight into the mechanisms of increase of serum immunoreactive free secretory component, secretory IgA and secretory IgM in various types of liver dysfunction.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The marked increase in total serum IgA concentrations in patients with cirrhosis could be due to a secondary effect of the initial release of free secretory component/ secretory IgA to the plasma compartment, leading to abnormalities in cytokine regulation (24)(25)(26). In addition, the abnormal permeability of the intestinal barrier in alcoholic liver cirrhosis patients could allow an increased antigenic load in the plasma as food antigens and lipopolysaccharide (27).…”

Section: Alcoholic Liver Cirrhosis Patientsmentioning

confidence: 99%

Increased Serum Concentration of IgA2 Subclass and IgA2/IgA1 Ratio: Specific Markers of Chronic Alcoholic Abuse?

Meillet

Labrousse²,

Benoit³

et al. 1997

Clinical Chemistry and Laboratory Medicine

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Summary:Enhanced serum IgA concentrations are common in alcoholic liver cirrhosis, but functional differences between IgA subclasses and their relation with interleukin-6 (IL-6) have not been described. Distinct immunoregulatory mechanisms may exist that selectively affect one subclass. This possibility prompted us to investigate the distribution of IgAl and IgA2 subclasses in the serum of 25 heavy alcohol drinkers (alcohol: 80 to 200 g per day) without clinical disorders, in comparison with 35 patients affected by alcoholic liver cirrhosis, 29 viral hepatitis patients and 33 social drinkers as a control group. Mean (± SD) IgA2 concentration (0.56 ± 0.31 g/1) was significantly increased (p < 0.01) in heavy alcohol drinkers, with an IgA2/IgAl ratio of 0.33 ± 0.12, while the mean total IgA concentration was similar to the control group. Mean IgAl and IgA2 concentrations were significantly increased (p < 0.001) in alcoholic liver cirrhosis patients (6.13 ± 4.52 g/1 and 1.83 ± 1.93 g/1 respectively, with an IgA2/IgAl ratio of 0.32 ± 0.19) and viral hepatitis patients (3.66 ± 2.59 g/1 and 0.69 ± 0.67 g/1 respectively, with an IgA2/IgAl ratio of 0.21 ±0.14) High serum IL-6 concentrations (34 ± 33 ng/1) were correlated with elevated IgAl and IgA2 concentrations only in patients with alcoholic liver cirrhosis. IgA2 subclass and IgA2/IgAl ratio could therefore be used as markers of chronic alcohol abuse directly related to the extent and duration of the alcohol abuse and the effectiveness of alcohol withdrawal.

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Secretory Immunoglobulin A in Hepatobiliary Diseases

Cited by 14 publications

References 35 publications

Expression of Major Histocompatibility Complex Class I Chain–Related Molecule A, NKG2D, and Transforming Growth Factor–β in the Liver of Humans with Alveolar Echinococcosis: New Actors in the Tolerance to Parasites?

Expression of Major Histocompatibility Complex Class I Chain–Related Molecule A, NKG2D, and Transforming Growth Factor–β in the Liver of Humans with Alveolar Echinococcosis: New Actors in the Tolerance to Parasites?

Serum and bile secretory immunoglobulins and secretory component during the early postoperative course after liver transplantation

Increased Serum Concentration of IgA2 Subclass and IgA2/IgA1 Ratio: Specific Markers of Chronic Alcoholic Abuse?

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