Secretory response of the human pancreas to continuous intravenous infusion of secretin.

Investigation of Exocrine Pancreatic Function by Continuous Infusion of Caerulein and Secretin in Normal Subjects and in Chronic Pancreatitis

“…In fact, the mean bicarbonate output is similar to that obtained with infusion of maximal doses of secretin (3,10,12,18) or secretin plus CCK (15,17). As a maximal dose of secretin was not used in this study, this result confirms the enhancing effect of caerulein on secretininduced bicarbonate secretion already reported by others (8,9).…”

Tests of Exocrine Pancreatic Function

“…Bilirubin was measured by Lagerlof (1942), Burton et al,(196Oa), and others in terms of the "icteric index", but more specific methods have also been employed to assess the biliary component (Banwell et al, 1967a, b;Zieve et al, 1966).…”

“…The latter is claimed to give a steady rate of secretion with less risk of increased motor activity and consequent loss of duodenal contents (Wormsley 1970a, b). For GIH secretin, maximal secretion of bicarbonate occurs with single doses of I to 3 CU/kg (Petersen, 1970a;Wormsley 1970a;Zimmerman et al, 1973) and with continuous infusion of 2 to 4 CU kg-1 h-1 (Banwell et al, 1967a;Wormsley, 1970a;Zimmerman et al, 1973). For Boots secretin maximal re- sponses occur with continuous infusion of 3 to 10 CHRU kg "!…”

“…The volume of juice is abnormally high but the bicarbonate output is usually normal. The response is seen in gall bladder disease, after cholecystectomy and, especially, in cirrhosis and haemochromatosis, (Banwell et al, 1967a;Bode et al, 1972;Burton et al, 1960a;Wormsley, 1970b;Zieve and Mulford, 1967).…”

Continuous Secretin Infusion with Pancreozymin Pretreatment as a Pancreatic Function Test

“…In order to obtain the information about the mass of functioning tissue, some authors recently tried to give an augmented dose of secretin by single injection (Hartley et al 1965;Lagerlof et al 1967;Dreiling et al 1974) or by continuous infusion (Banwell et al 1967;Pascal et al 1968;Wormsley 1968). But the dose of secretin producing the maximal response in the bicarbonate secretion is not yet settled at present.…”