Section Review Central & Peripheral Nervous Systems: Mirtazapine - a novel antidepressant compound currently undergoing clinical evaluation

4-(Phenylsulfonyl)piperidines: Novel, Selective, and Bioavailable 5-HT2AReceptor Antagonists

“…Blockade of 5-HT 2A receptors (antagonism) has been implicated in the beneficial effects of newly released antidepressants such as mirtazepine, nefazodone, and atypical antipsychotic drugs such as risperidone and olanzapine − Thus, while blockade of the 5-HT 2A receptor has been demonstrated to give rise to quantifiable behavioral effects in animal models, such as the DOI-induced head-twitch, it remains unclear whether specific blockade of central 5-HT 2A receptors will be therapeutically beneficial . Recently, compounds selective for the 5-HT 2 family of receptors such as fananserin ( 1 ), MDL100907 ( 2 ), and eplivanserin ( 3 ) have been described (Figure ).…”