Secular trend analysis of antibiotic utilisation in some hospitals in Southern Sichuan from 2010 to 2020

Abstract

In order to assess the effectiveness of the Special Antimicrobial Stewardship Campaign launched by Ministry of Health of China in 2011, this study focused on the effectiveness and trends in the clinical use of antimicrobial drugs in selected hospitals in Southern Sichuan, China. This study collected and analyzed antibiotic data from 9 hospitals in Southern Sichuanin 2010, 2015, and 2020, including the rate of antibiotic use, expense, the intensity of antibiotic use and antibiotic use during the type I incisions of perioperative period. After 10 years of continuous improvement, the utilization rate of antibiotics in outpatients of the 9 hospitals continued to decline and was controlled below 20% by 2020, while the utilization rate in inpatients also significantly decreased, most were controlled within 60%. The use intensity of antibiotics (DDD (defined daily doses) per 100 bed-days) decreased from an average of 79.95 in 2010 to 37.96 in 2020. The prophylactic use of antibiotics decreased significantly in type I incision. The proportion of use within 30 min–1 h before operation was significantly increased. After the special rectification and sustained development of the clinical application of antibiotics, the relevant indicators of antibiotics tend to be stable, indicating that this Administration of antimicrobial drugs is conducive to improving the level of rational clinical application of antibiotics.

Trends in adverse drug reactions between 2011 and 2022 in a tertiary hospital in China through retrospective analysis

“…However, the overall antimicrobial drug ADR reporting rate showed a decreasing trend, which may be attributed to the fact that from 2011, the China Food and Drug Administration carried out a special campaign to begin to strengthen the management of antimicrobial drugs 18 and to reduce the misuse of antimicrobial drugs. The hospital strictly follows the Guiding Principles for the Clinical Application of Antimicrobial Drugs, standardizes the use of antimicrobial drugs 19 . Before antibiotic treatment, it is necessary to clarify the signs of infection as far as possible and do a good job of pharmaceutical care, and formulate an individualized medication plan to avoid unreasonable dosage and drug selection.…”