Secundarellone A, B, and C from the leaves of Justicia secunda VAHL

Antioxidant, anti-inflammatory and antinociceptive activities of methanolic extract of Justicia secunda Vahl leaf

“…13,[16][17][18] Phytochemical screening of the plant has shown the presences of tannins, flavonoids, alkaloids, quinines and anthocyanins. 19 Luteolin, aurantamide acetate, auranamide, quindoline and pyrrolidone derivatives; secundarellone A, B and C have been isolated from J. secunda. [19][20][21] Notwithstanding the popular uses of J. secunda in folkloric medicine only few pharmacological studies have been done on the plant.…”

“…19 Luteolin, aurantamide acetate, auranamide, quindoline and pyrrolidone derivatives; secundarellone A, B and C have been isolated from J. secunda. [19][20][21] Notwithstanding the popular uses of J. secunda in folkloric medicine only few pharmacological studies have been done on the plant. 22 This study investigated the antioxidant, anti-inflammatory, and antinociceptive effects of J. secunda leaf methanolic extract (J. secunda).…”

HPTLC Bioautography Guided Isolation of α‐Glucosidase Inhibiting Compounds from Justicia secunda Vahl (Acanthaceae)

“…Compound 2 could be identified via HPLC and ESI‐MS n analyses as the diastereomeric mixture of the pyrrolidones secundarellone B and C (Fig. ), according to our previous studies for J. secunda (Theiler et al , ). HPLC comparison (including UV‐DAD and ELSD) of compound 2 and the previously isolated secundarellone B and C revealed the identical retention time (minute 9 corresponding to about 9.5% acetonitrile) on a LiChrospher® 100 RP‐18e column (250 mm × 4 mm, 5 μm) and identical UV spectra.…”

“…In the present article, we report on the HPTLC bioautography guided detection of the α-glucosidase inhibiting potential of J. secunda resulting in the isolation of two active diastereomeric mixtures from the methanol extract of the leaves. Compound 1 was new and structurally elucidated as 2-caffeoyloxy-4-hydroxy-glutaric acid, compound 2 was identified as the mixture of the diastereomers secundarellone B and C, published in our previous studies for J. secunda (Theiler et al, 2014).…”

“…Auranamide, aurantiamide acetate, and quindoline were isolated from the dichloromethane extract of the stems (Calderón et al, 2013). We recently reported on the pyrrolidones secundarellone A, B, and C, which have been exclusively detected in J. secunda so far (Theiler et al, 2014).…”